Transthyretin Amyloidosis Treatment Market Size and Scope 2026 to 2035

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Segmentation of Transthyretin Amyloidosis Treatment Market-

Transthyretin Amyloidosis Treatment Market By Type-

  • ATTR-PN
  • ATTR-CM

transthyretin

Transthyretin Amyloidosis Treatment Market By Therapy-

  • Targeted Therapy
    • Onpattro
    • Inotersen
    • Vyndaqel/Vyndamax
  • Supportive Therapy
  • Pipeline Therapy

Transthyretin Amyloidosis Treatment Market By Disease Type-

  • Hereditary Transthyretin Amyloidosis
    • Polyneuropathy
    • Cardiomyopathy
    • Mixed Type
  • Wild Type Amyloidosis

Transthyretin Amyloidosis Treatment Market By Distribution Channel-

  • Hospital Pharmacies
  • Specialty Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

Transthyretin Amyloidosis Treatment Market By Region-

  • North America-
    • The US
    • Canada
  • Europe-
    • Germany
    • The UK
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia-Pacific-
    • China
    • Japan
    • India
    • South Korea
    • South East Asia
    • Rest of Asia Pacific
  • Latin America-
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
  •  Middle East & Africa-
    • GCC Countries
    • South Africa
    • Rest of Middle East and Afric

Chapter 1.       Methodology and Scope

1.1.      Research Methodology

1.2.      Research Scope & Assumptions

Chapter 2.       Executive Summary

Chapter 3.       Global Transthyretin Amyloidosis Treatment Market Snapshot

Chapter 4.       Global Transthyretin Amyloidosis Treatment Market Variables, Trends & Scope

4.1.      Market Segmentation & Scope

4.2.      Drivers

4.3.      Challenges

4.4.      Trends

4.5.      Investment and Funding Analysis

4.6.      Porter's Five Forces Analysis

4.7.      Incremental Opportunity Analysis (US$ MN), 2021-2034

4.8.      Global Transthyretin Amyloidosis Treatment Market Penetration & Growth Prospect Mapping (US$ Mn), 2024-2034

4.9.      Competitive Landscape & Market Share Analysis, By Key Player (2024)

4.10.    Use/impact of AI on Transthyretin Amyloidosis Treatment Industry Trends

Chapter 5.       Transthyretin Amyloidosis Treatment Market Segmentation 1: By Therapy, Estimates & Trend Analysis

5.1.      Market Share by Therapy, 2024 & 2034

5.2.      Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Therapy:

5.2.1.   Targeted Therapy

5.2.1.1.            Onpattro

5.2.1.2.            Inotersen

5.2.1.3.            Vyndaqel/Vyndamax

5.2.2.   Supportive Therapy

5.2.3.   Pipeline Therapy

Chapter 6.       Transthyretin Amyloidosis Treatment Market Segmentation 2: By Type, Estimates & Trend Analysis

6.1.      Market Share by Type, 2024 & 2034

6.2.      Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Types:

6.2.1.   ATTR-PN

6.2.2.   ATTR-CM

Chapter 7.       Transthyretin Amyloidosis Treatment Market Segmentation 3: By Disease Type, Estimates & Trend Analysis

7.1.      Market Share by Disease Type, 2024 & 2034

7.2.      Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Disease Types:

7.2.1.   Hereditary  Transthyretin Amyloidosis

7.2.1.1.            Polyneuropathy

7.2.1.2.            Cardiomyopathy

7.2.1.3.            Mixed Type

7.2.2.   Wild Type Amyloidosis

Chapter 8.       Transthyretin Amyloidosis Treatment Market Segmentation 4: By Distribution Channel Industry, Estimates & Trend Analysis

8.1.      Market Share by Distribution Channel Industry, 2024 & 2034

8.2.      Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Distribution Channel Industrys:

8.2.1.   Hospital Pharmacies

8.2.2.   Specialty Pharmacies

8.2.3.   Retail Pharmacies

8.2.4.   Online Pharmacies

Chapter 9.       Transthyretin Amyloidosis Treatment Market Segmentation 5: Regional Estimates & Trend Analysis

9.1.      Global Transthyretin Amyloidosis Treatment Market, Regional Snapshot 2024 & 2034

9.2.      North America

9.2.1.   North America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.2.1.1.            US

9.2.1.2.            Canada

9.2.2.   North America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Therapy, 2021-2034

9.2.3.   North America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.2.4.   North America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Disease Type, 2021-2034

9.2.5.   North America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Distribution Channel Industry, 2021-2034

9.3.      Europe

9.3.1.   Europe Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.3.1.1.            Germany

9.3.1.2.            U.K.

9.3.1.3.            France

9.3.1.4.            Italy

9.3.1.5.            Spain

9.3.1.6.            Rest of Europe

9.3.2.   Europe Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Therapy, 2021-2034

9.3.3.   Europe Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.3.4.   Europe Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Disease Type, 2021-2034

9.3.5.   Europe Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Distribution Channel Industry, 2021-2034

9.4.      Asia Pacific

9.4.1.   Asia Pacific Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.4.1.1.            India

9.4.1.2.            China

9.4.1.3.            Japan

9.4.1.4.            Australia

9.4.1.5.            South Korea

9.4.1.6.            Hong Kong

9.4.1.7.            Southeast Asia

9.4.1.8.            Rest of Asia Pacific

9.4.2.   Asia Pacific Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Therapy, 2021-2034

9.4.3.   Asia Pacific Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.4.4.   Asia Pacific Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts By Disease Type, 2021-2034

9.4.5.   Asia Pacific Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Distribution Channel Industry, 2021-2034

9.5.      Latin America

9.5.1.   Latin America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.5.1.1.            Brazil

9.5.1.2.            Mexico

9.5.1.3.            Rest of Latin America

9.5.2.   Latin America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Therapy, 2021-2034

9.5.3.   Latin America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.5.4.   Latin America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Disease Type, 2021-2034

9.5.5.   Latin America Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Distribution Channel Industry, 2021-2034

9.6.      Middle East & Africa

9.6.1.   Middle East & Africa Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034

9.6.1.1.            GCC Countries

9.6.1.2.            Israel

9.6.1.3.            South Africa

9.6.1.4.            Rest of Middle East and Africa

9.6.2.   Middle East & Africa Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Therapy, 2021-2034

9.6.3.   Middle East & Africa Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.6.4.   Middle East & Africa Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Disease Type, 2021-2034

9.6.5.   Middle East & Africa Transthyretin Amyloidosis Treatment Market Revenue (US$ Million) Estimates and Forecasts by Distribution Channel Industry, 2021-2034

Chapter 10.     Competitive Landscape

10.1.    Major Mergers and Acquisitions/Strategic Alliances

10.2.    Company Profiles

10.2.1. Pfizer Inc.

10.2.1.1.          Business Overview

10.2.1.2.          Key Product/Service Offerings

10.2.1.3.          Financial PerTherapyance

10.2.1.4.          Geographical Presence

10.2.1.5.          Recent Developments with Business Strategy

10.2.2. Johnson & Johnson Services, Inc.

10.2.3. Ionis Pharmaceuticals, Inc.

10.2.4. Alnylam Pharmaceuticals, Inc.

10.2.5. BridgeBio Pharma, Inc.

10.2.6. Bristol-Myers Squibb Company

10.2.7. Acrotech Biopharma

10.2.8. AstraZeneca

10.2.9. Astellas Pharma, Inc.

10.2.10.           Prothena

10.2.11.           SOM Biotech

10.2.12.           Other Market Players

Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

Transthyretin Amyloidosis Treatment Market Size is valued at USD 5.5 Bn in 2024 and is predicted to reach USD 11.7 Bn by the year 2034

Transthyretin Amyloidosis Treatment Market is expected to grow at a 8.0% CAGR during the forecast period for 2025-2034.

Ionis Pharmaceuticals, Inc., Pfizer Inc., AstraZeneca, Johnson & Johnson Services, Inc., Alnylam Pharmaceuticals, Inc., Astellas Pharma, Inc.. BridgeB

Type, Therapy, Disease Type, And Distribution Channel are the key segments of the Transthyretin Amyloidosis Treatment Market.

North American region is leading the Transthyretin Amyloidosis Treatment Market.

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