96.JPG)
Global mRNA Synthesis Raw Materials Market Size is valued at USD 1.8 Bn in 2024 and is predicted to reach USD 3.4 Bn by the year 2034 at a 6.6% CAGR during the forecast period for 2025-2034.
Key Industry Insights & Findings from the Report:
The mRNA synthesis raw material market revolves around the essential ingredients needed to produce messenger RNA (mRNA). Significant raw materials include nucleotides (the building blocks), enzymes (which help construct the mRNA), capping agents (that protect the message), and modified bases (to enhance performance). This market study encompasses companies that manufacture and supply these materials to biotech firms, pharmaceutical manufacturers, and research laboratories.
mRNA vaccines are more efficacious, have better immunogenicity, and cost less to produce than traditional treatments. For the projection period, mRNA synthesis and production services are anticipated to have rapid market expansion due to ongoing breakthroughs and advancements. Due to the key market players' goal of providing superior quality and efficacy products, there is an increasing demand for high-quality raw materials for efficient mRNA synthesis. This is essential for developing safe and effective pharmaceutical goods, vaccines, and medications. Key competitors' alliances, acquisitions, and partnerships to increase the supply of raw materials also drive the industry. The market is expanding due to new pharmaceutical companies' inventions, improved medical technology, and greater customization of facilities and services with higher quality and effectiveness.
The mRNA synthesis raw materials market is segmented into type, application, and end-user. Based on type, the market is segmented into capping agents, nucleotides, plasmid DNA, enzymes, and others. Based on the application, the market is divided into vaccine production, therapeutics production, and others. Based on the End-user, the market is divided into biopharmaceutical and pharmaceutical companies, cross and CMOS, and academic and research institutes.
Based on type, the market is segmented into capping agents, nucleotides, plasmid DNA, enzymes, and others. Among these, the capping agents’ segment is expected to have the highest growth rate during the forecast period. Capping agents are critical for mRNA stability, translation efficiency, and reduced immunogenicity, making them essential components in the synthesis of functional, therapeutic-grade mRNA. They play a vital role in the formation of the 5' cap structure, which is crucial for effective mRNA translation. The demand for capping agents has grown significantly with the expanding use of mRNA technologies in vaccines, gene therapies, and personalized medicines. This segment is further driven by innovations in cap analogs and enzymatic capping kits, which enhance the efficiency and safety of mRNA products. In comparison, nucleotides including modified variants like N1-methyl-pseudouridine are also used in large volumes but have a relatively lower unit cost, making their overall market share smaller despite their importance in mRNA synthesis.
Based on the application, the market is divided into vaccine production, therapeutics production, and others. Among these, the vaccine production segment dominates the market. Vaccine production is the major demand driver in the mRNA synthesis raw materials market, especially in the post-COVID-19 era. The success of mRNA-based vaccines during the pandemic has accelerated research and development efforts, leading to a strong pipeline of mRNA vaccines targeting infectious diseases such as influenza, RSV, and HIV. This segment continues to be supported by government funding and global health initiatives aimed at pandemic preparedness and public health. While therapeutics production is rapidly growing, it remains an emerging segment, primarily focused on oncology, rare diseases, and genetic disorders. Although its current volume is smaller compared to vaccines, it holds significant growth potential due to increasing investments and clinical advancements.
North America is home to leading biotech and pharmaceutical companies, making it a major hub for the consumption and production of mRNA synthesis raw materials. The region boasts a well-established research ecosystem supported by top universities, advanced research institutes, and substantial funding from both public agencies, such as the NIH and BARDA, as well as private investors. Additionally, strong regulatory support for mRNA technologies through mechanisms like FDA fast-tracks and Emergency Use Authorizations has accelerated development timelines and market access. Combined with significant investments in pandemic preparedness and biotechnology innovation, these factors have firmly positioned North America as the dominant region in the mRNA synthesis raw materials market.
|
Report Attribute |
Specifications |
|
Market Size Value In 2024 |
USD 1.8 Billion |
|
Revenue Forecast In 2034 |
USD 3.4 Billion |
|
Growth Rate CAGR |
CAGR of 6.6% from 2025 to 2034 |
|
Quantitative Units |
Representation of revenue in US$ Million and CAGR from 2025 to 2034 |
|
Historic Year |
2021 to 2024 |
|
Forecast Year |
2025-2034 |
|
Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
|
Segments Covered |
By Type, By Application, By End-User |
|
Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
|
Country Scope |
U.S.; Canada; Germany; China; India; Japan; Brazil; Mexico ;The UK; France; Italy; Spain; South Korea; South East Asia |
|
Competitive Landscape |
F. Hoffmann-La Roche Ltd., Jena Bioscience GmbH, Merck KGaA, Yeasen Biotechnology (Shanghai) Co., Ltd., BOC Sciences, Thermo Fisher Scientific, Inc., Maravai LifeSciences, New England Biolabs, Creative Biogene, HONGENE |
|
Customization Scope |
Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape. |
|
Pricing And Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global MRNA Synthesis Raw Materials Market Snapshot
Chapter 4. Global MRNA Synthesis Raw Materials Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2025-2034
4.8. Global MRNA Synthesis Raw Materials Market Penetration & Growth Prospect Mapping (US$ Mn), 2024-2034
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2024)
Chapter 5. MRNA Synthesis Raw Materials Market Segmentation 1: By Type, Estimates & Trend Analysis
5.1. Market Share by Type, 2024 & 2034
5.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Type:
5.2.1. Capping Agents
5.2.1.1. Cappping Reagents
5.2.1.2. ARCA (Anti-Reverse Cap Analog)
5.2.1.3. Others (Vaccinia Capping Enzyme, etc.)
5.2.2. Nucleotides
5.2.2.1. Modified Nucleic Acids
5.2.2.1.1. N1-methylpseudouridine-triphosphate
5.2.2.1.2. 5-Methylcytidine triphosphate (5mCTP)
5.2.2.1.3. Others
5.2.2.2. Natural Nucleic Acids
5.2.2.2.1. Adenine
5.2.2.2.2. Guanine
5.2.2.2.3. Cytosine
5.2.2.2.4. Uracil
5.2.2.3. Plasmid DNA
5.2.2.4. Enzymes
5.2.2.4.1. T7 RNA Polymerase
5.2.2.4.2. SP6/T3 Polymerase
5.2.2.4.4. RNase Inhibitor
5.2.2.4.5. DNase
5.2.2.4.6. Others
5.2.2.5. Lipids & Formulation Materials
5.2.2.5.1. Ionizable Lipids
5.2.2.5.2. PEG-Lipids
5.2.2.6. Purification & Analytical Materials
Chapter 6. MRNA Synthesis Raw Materials Market Segmentation 2: By Grade Type, Estimates & Trend Analysis
6.1. Market Share by Grade Type, 2024 & 2034
6.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Grade Type:
6.2.1. Research Grade
6.2.2. GMP Grade
Chapter 7. MRNA Synthesis Raw Materials Market Segmentation 3: By Application, Estimates & Trend Analysis
7.1. Market Share by Application, 2024 & 2034
7.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:
7.2.1. Therapeutics Typeion
7.2.2. Vaccine Typeion
7.2.3. Others
Chapter 8. MRNA Synthesis Raw Materials Market Segmentation 4: By End-user, Estimates & Trend Analysis
8.1. Market Share by End-user, 2024 & 2034
8.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End-user:
8.2.1. Biotechnology & Pharmaceutical Companies
8.2.2. CMOs & CROs
8.2.3. Research and Academic Institutes
Chapter 9. MRNA Synthesis Raw Materials Market Segmentation 5: Regional Estimates & Trend Analysis
9.1. Global MRNA Synthesis Raw Materials Market, Regional Snapshot 2024 & 2034
9.2. North America
9.2.1. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034
9.2.1.1. US
9.2.1.2. Canada
9.2.2. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.2.3. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.2.4. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.2.5. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034
9.3. Europe
9.3.1. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034
9.3.1.1. Germany
9.3.1.2. U.K.
9.3.1.3. France
9.3.1.4. Italy
9.3.1.5. Spain
9.3.1.6. Rest of Europe
9.3.2. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.3.3. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.3.4. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.3.5. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034
9.4. Asia Pacific
9.4.1. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034
9.4.1.1. India
9.4.1.2. China
9.4.1.3. Japan
9.4.1.4. Australia
9.4.1.5. South Korea
9.4.1.6. Hong Kong
9.4.1.7. Southeast Asia
9.4.1.8. Rest of Asia Pacific
9.4.2. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.4.3. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.4.4. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.4.5. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034
9.5. Latin America
9.5.1. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034
9.5.1.1. Brazil
9.5.1.2. Mexico
9.5.1.3. Rest of Latin America
9.5.2. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.5.3. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.5.4. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.5.5. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034
9.6. Middle East & Africa
9.6.1. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by country, 2021-2034
9.6.1.1. GCC Countries
9.6.1.2. Israel
9.6.1.3. South Africa
9.6.1.4. Rest of Middle East and Africa
9.6.2. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.6.3. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.6.4. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.6.5. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034
Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles
10.2.1. Roche
10.2.1.1. Business Overview
10.2.1.2. Key Type/Service
10.2.1.3. Financial Performance
10.2.1.4. Geographical Presence
10.2.1.5. Recent Developments with Business Strategy
10.2.2. Thermo Fisher Scientific Inc
10.2.3. Creative Enzymes
10.2.4. Promega Corporation
10.2.5. Merck
10.2.6. BOC Sciences
10.2.7. Jena Bioscience GmbH
10.2.8. Aldevron
10.2.9. Sichuan Qingmu Pharmaceutical Co., Ltd
10.2.10. TriLink BioTechnologies
10.2.11. Creative Biogene
10.2.12. New England Biolabs
10.2.13. Other Prominent Players
10.2.13.1. Bio-Synthesis Inc.
10.2.13.2. Integrated DNA Technologies (IDT)
10.2.13.3. GenScript Biotech Corporation
10.2.13.4. Yeasen Biotechnology (Shanghai) Co., Ltd.
10.2.13.5. Eurogentec
10.2.13.6. Beijing SBS Genetech Co., Ltd.
10.2.13.7. Lucigen (LGC Biosearch Technologies)
10.2.13.8. BioCat GmbH
10.2.13.9. ATDBio Ltd.
10.2.13.10. Bio Basic Inc.
10.2.13.11. Sartorius AG
10.2.13.12. HONGENE
10.2.13.13. ArcticZymes Technologies
mRNA Synthesis Raw Materials Market - By Type
mRNA Synthesis Raw Materials Market – By Grade Type
mRNA Synthesis Raw Materials Market – By Application
mRNA Synthesis Raw Materials Market – By End-user
mRNA Synthesis Raw Materials Market By Region-
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
To know more about the research methodology used for this study, kindly contact us/click here.
