The gRNA Synthesis Market Size is valued at USD 492.4 Mn in 2023 and is predicted to reach USD 1,751.4 Mn by the year 2031 at an 17.4% CAGR during the forecast period for 2024-2031.
The synthesis of guide RNA (gRNA) comprises the design and production of RNA molecules that direct CRISPR-associated (Cas) nucleases to specific genomic targets through complementary base pairing. This mechanism is essential for accurate gene editing in CRISPR technologies, facilitating applications in medicines, biomedical research, agriculture, and diagnostics. This technology has transformed fields such as medicine, agriculture, and biotechnology, becoming a crucial tool for researchers aiming to modify genes with high accuracy. In medicine, gRNA is used to develop gene therapies for genetic disorders, while in agriculture, it benefits in creating GMOs that resist pests and environmental stresses. It also plays a key role in next-generation sequencing (NGS) technologies, broadening its impact in genomic research and diagnostics.
A major factor driving the gRNA Synthesis market's growth is the increasing demand for personalized medicine. As healthcare moves towards modified treatments, the need for precise genetic modifications grows, boosting demand for gRNA-based technologies. This trend is further supported by significant investments in research and development, particularly in the biomedical sector, which is expected to fuel the market's expansion in the coming years.
The gRNA Synthesis market is product & services, gRNA type, application, and end-use. By product & services the market is segmented into products, custom gRNA synthesis services, products is sub segmented into gRNA final products, gRNA Synthesis Products. gRNA synthesis products is sub segmented into gRNA Synthesis Kits, Plasmids, Others. By gRNA type market is categorized into research-use, GMP-grade. By application market is categorized into genome engineering, disease model studies, functional genomics, epigenetics, and others. By end-use the market is categorized into pharmaceutical & biotechnology companies, academic research institutes, CMOs & CROs.
The custom gRNA synthesis services segment is set to experience the highest growth in the gRNA Synthesis market due to increasing demand for precision in gene editing, advancements in biotechnology, and diverse applications. Researchers require custom gRNAs to achieve greater accuracy, reduce off-target effects, and improve the efficiency of the CRISPR/Cas9 system, driving demand for these services. Biotechnology advancements have made gRNA synthesis more accessible and cost-effective, allowing researchers at all levels to obtain high-quality custom gRNAs. Additionally, the broad applicability of custom gRNAs in areas like functional genomics, disease models, and therapeutic interventions further expands their market potential.
The GMP-grade segment of the gRNA market is expected to see significant growth due to the rising demand for high-quality, regulatory-compliant products, particularly in clinical applications. GMP-grade gRNA is produced under strict quality control standards, ensuring safety and efficacy, which is essential as gene editing technologies like CRISPR advance toward therapeutic use. The growing focus on gene therapy for treating genetic disorders also drives demand, with pharmaceutical and biotech companies investing in novel therapies requiring GMP-grade gRNA for effective and safe gene editing in clinical trials and personalized medicine.
North America, particularly the U.S., is a key driver of the gRNA Synthesis market due to the presence of major players like Thermo Fisher Scientific, Merck KGaA, and Synthego, who are heavily investing in R&D for innovative gRNA products. The region benefits from substantial R&D investments in genomic research, alongside strong government support, including a 2023 Biden executive order aimed at enhancing gRNA manufacturing capabilities. Additionally, NIH-funded research has played a pivotal role in advancing genetic engineering and establishing the $40 billion biotech industry.
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Report Attribute |
Specifications |
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Market Size Value In 2023 |
USD 492.4 Mn |
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Revenue Forecast In 2031 |
USD 1,751.4 Mn |
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Growth Rate CAGR |
CAGR of 17.4% from 2024 to 2031 |
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Quantitative Units |
Representation of revenue in US$ Mn and CAGR from 2024 to 2031 |
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Historic Year |
2019 to 2023 |
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Forecast Year |
2024-2031 |
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Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
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Segments Covered |
By Product & Services, gRNA Type, Application, End-use and By Region |
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Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
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Country Scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; The UK; France; Italy; Spain; China; Japan; India; South Korea; Southeast Asia; South Korea; Southeast Asia |
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Competitive Landscape |
Thermo Fisher Scientific Inc., Agilent Technologies Inc., System Biosciences, LLC., Jena Bioscience GmbH, Merck KGaA, GENEWIZ (Azenta Life Sciences), Takara Bio Inc., Synbio Technologies, Horizon Discovery Ltd., Synthego |
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Customization Scope |
Free customization report with the procurement of the report, Modifications to the regional and segment scope. Geographic competitive landscape. |
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Pricing and Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global gRNA Synthesis Market Snapshot
Chapter 4. Global gRNA Synthesis Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis
Chapter 5. Market Segmentation 1: by Product & Services Estimates & Trend Analysis
5.1. by Product & Services & Market Share, 2023 & 2031
5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Product & Services:
5.2.1. Products
5.2.1.1. gRNA Final Products
5.2.1.2. gRNA Synthesis Products
5.2.1.2.1. gRNA Synthesis Kits
5.2.1.2.2. Plasmids
5.2.1.2.3. Others
5.2.2. Custom gRNA Synthesis Services
Chapter 6. Market Segmentation 2: by gRNA Type Estimates & Trend Analysis
6.1. by gRNA Type & Market Share, 2023 & 2031
6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by gRNA Type:
6.2.1. Research-Use
6.2.2. GMP-grade
Chapter 7. Market Segmentation 3: by Application Estimates & Trend Analysis
7.1. by Application & Market Share, 2023 & 2031
7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Application:
7.2.1. Genome Engineering
7.2.2. Disease Model Studies
7.2.3. Functional Genomics
7.2.4. Epigenetics
7.2.5. Others
Chapter 8. Market Segmentation 4: by End-use Estimates & Trend Analysis
8.1. by End-use & Market Share, 2023 & 2031
8.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by End-use:
8.2.1. Pharmaceutical & Biotechnology Companies
8.2.2. Academic Research Institutes
8.2.3. CMOs & CROs
Chapter 9. gRNA Synthesis Market Segmentation 5: Regional Estimates & Trend Analysis
9.1. North America
9.1.1. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.1.2. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by gRNA Type, 2024-2031
9.1.3. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.1.4. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.1.5. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
9.2. Europe
9.2.1. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.2.2. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by GRNA Type, 2024-2031
9.2.3. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.2.4. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.2.5. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
9.3. Asia Pacific
9.3.1. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.3.2. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by GRNA Type, 2024-2031
9.3.3. Asia-Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.3.4. Asia-Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.3.5. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
9.4. Latin America
9.4.1. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.4.2. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by gRNA Type, 2024-2031
9.4.3. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.4.4. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.4.5. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
9.5. Middle East & Africa
9.5.1. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.5.2. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by RNA Type, 2024-2031
9.5.3. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.5.4. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.5.5. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles
10.2.1. Agilent Technologies Inc.
10.2.2. GENEWIZ (Azenta Life Sciences)
10.2.3. Horizon Discovery Ltd.
10.2.4. Jena Bioscience GmbH
10.2.5. Merck KGaA
10.2.6. Synbio Technologies
10.2.7. Synthego
10.2.8. System Biosciences, LLC.
10.2.9. Takara Bio Inc.
10.2.10. Thermo Fisher Scientific Inc.
10.2.11. Other Prominent Players
gRNA Synthesis Market by Product & Services -
gRNA Synthesis Market by gRNA Type -
gRNA Synthesis Market by Application -
gRNA Synthesis Market by End-use -
gRNA Synthesis Market by Region-
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
