gRNA Synthesis Market Size, Share Detailed Report 2025 to 2034

Report Id: 2735 Pages: 176 Last Updated: 18 December 2025 Format: PDF / PPT / Excel / Power BI
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Segmentation of gRNA Synthesis Market -

gRNA Synthesis Market by Product & Services -

  • Products
    • gRNA Final Products
    • gRNA Synthesis Products
      • gRNA Synthesis Kits
      • Plasmids
      • Others
  • Custom gRNA Synthesis Services

gRNA Synthesis Market seg

gRNA Synthesis Market by gRNA Type -

  • Research-Use
  • GMP-grade

 gRNA Synthesis Market by Application -

  • Genome Engineering
  • Disease Model Studies
  • Functional Genomics
  • Epigenetics
  • Others

gRNA Synthesis Market by End-use -

  • Pharmaceutical & Biotechnology Companies
  • Academic Research Institutes
  • CMOs & CROs

gRNA Synthesis Market by Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global gRNA Synthesis Market Snapshot

Chapter 4. Global gRNA Synthesis Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: by Product & Services Estimates & Trend Analysis
5.1. by Product & Services & Market Share, 2023 & 2031
5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Product & Services:

5.2.1. Products

5.2.1.1. gRNA Final Products
5.2.1.2. gRNA Synthesis Products

5.2.1.2.1. gRNA Synthesis Kits
5.2.1.2.2. Plasmids
5.2.1.2.3. Others

5.2.2. Custom gRNA Synthesis Services

Chapter 6. Market Segmentation 2: by gRNA Type Estimates & Trend Analysis
6.1. by gRNA Type & Market Share, 2023 & 2031
6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by gRNA Type:

6.2.1. Research-Use
6.2.2. GMP-grade

Chapter 7. Market Segmentation 3: by Application Estimates & Trend Analysis
7.1. by Application & Market Share, 2023 & 2031
7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Application:

7.2.1. Genome Engineering
7.2.2. Disease Model Studies
7.2.3. Functional Genomics
7.2.4. Epigenetics
7.2.5. Others

Chapter 8. Market Segmentation 4: by End-use Estimates & Trend Analysis
8.1. by End-use & Market Share, 2023 & 2031
8.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by End-use:

8.2.1. Pharmaceutical & Biotechnology Companies
8.2.2. Academic Research Institutes
8.2.3. CMOs & CROs

Chapter 9. gRNA Synthesis Market Segmentation 5: Regional Estimates & Trend Analysis

9.1. North America
9.1.1. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.1.2. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by gRNA Type, 2024-2031
9.1.3. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.1.4. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.1.5. North America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.2. Europe
9.2.1. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.2.2. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by GRNA Type, 2024-2031
9.2.3. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.2.4. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.2.5. Europe gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.3. Asia Pacific
9.3.1. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.3.2. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by GRNA Type, 2024-2031
9.3.3. Asia-Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.3.4. Asia-Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.3.5. Asia Pacific gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.4. Latin America
9.4.1. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.4.2. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by gRNA Type, 2024-2031
9.4.3. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.4.4. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.4.5. Latin America gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.5. Middle East & Africa
9.5.1. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product & Services, 2024-2031
9.5.2. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by RNA Type, 2024-2031
9.5.3. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
9.5.4. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2024-2031
9.5.5. Middle East & Africa gRNA Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles

10.2.1. Agilent Technologies Inc.
10.2.2. GENEWIZ (Azenta Life Sciences)
10.2.3. Horizon Discovery Ltd.
10.2.4. Jena Bioscience GmbH
10.2.5. Merck KGaA
10.2.6. Synbio Technologies
10.2.7. Synthego
10.2.8. System Biosciences, LLC.
10.2.9. Takara Bio Inc.
10.2.10. Thermo Fisher Scientific Inc.
10.2.11. Other Prominent Players

Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

The gRNA Synthesis Market Size is valued at USD 492.4 Mn in 2023 and is predicted to reach USD 1,751.4 Mn by the year 2031

The gRNA Synthesis Market is expected to grow at an 17.4% CAGR during the forecast period for 2025 to 2034.

Thermo Fisher Scientific Inc., Agilent Technologies Inc., System Biosciences, LLC., Jena Bioscience GmbH, Merck KGaA, GENEWIZ (Azenta Life Sciences),

gRNA Synthesis market is product & services, gRNA type, application, and end-use.

North America region is leading the gRNA Synthesis market.

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