mRNA Synthesis Raw Materials Market Size, Share and Trends Report 2025 to 2034

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Segmentation of mRNA Synthesis Raw Materials Market-

mRNA Synthesis Raw Materials Market - By Type

  • Capping Agents
    • CleanCap Reagents
    • ARCA (Anti-Reverse Cap Analog)
    • Others
  • Nucleotides
    • Modified Nucleic Acids
      • N1-methylpseudouridine-triphosphate
      • 5-Methylcytidine triphosphate (5mCTP)
      • Others
    • Natural Nucleic Acids
      • Adenine
      • Guanine
      • Cytosine
      • Uracil
  • Plasmid DNA
  • Enzymes
    • T7 RNA Polymerase
    • SP6/T3 Polymerase
    • RNase Inhibitor
    • DNase
    • Others
  • Lipids & Formulation Materials
    • Ionizable Lipids
    • PEG-Lipids
  • Purification & Analytical Materials

mRNA Synthesis Raw Materials Market

mRNA Synthesis Raw Materials Market – By Grade Type

  • Research Grade
  • GMP Grade

mRNA Synthesis Raw Materials Market – By Application

  • Vaccine Production
  • Therapeutics Production
  • Others

mRNA Synthesis Raw Materials Market – By End-user

  • Biopharmaceutical & Pharmaceutical Companies
  • CROs & CMOs
  • Academic & Research Institutes

mRNA Synthesis Raw Materials Market By Region-

North America-

  • The US
  • Canada

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of Middle East and Africa

Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global MRNA Synthesis Raw Materials Market Snapshot

Chapter 4. Global MRNA Synthesis Raw Materials Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2025-2034
4.8. Global MRNA Synthesis Raw Materials Market Penetration & Growth Prospect Mapping (US$ Mn), 2024-2034
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2024)

Chapter 5. MRNA Synthesis Raw Materials Market Segmentation 1: By Type, Estimates & Trend Analysis
5.1. Market Share by Type, 2024 & 2034
5.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Type:

5.2.1. Capping Agents

5.2.1.1. Cappping Reagents
5.2.1.2. ARCA (Anti-Reverse Cap Analog)
5.2.1.3. Others (Vaccinia Capping Enzyme, etc.)

5.2.2. Nucleotides

5.2.2.1. Modified Nucleic Acids

5.2.2.1.1. N1-methylpseudouridine-triphosphate
5.2.2.1.2. 5-Methylcytidine triphosphate (5mCTP)
5.2.2.1.3. Others

5.2.2.2. Natural Nucleic Acids

5.2.2.2.1. Adenine
5.2.2.2.2. Guanine
5.2.2.2.3. Cytosine
5.2.2.2.4. Uracil

5.2.2.3. Plasmid DNA

5.2.2.4. Enzymes

5.2.2.4.1. T7 RNA Polymerase
5.2.2.4.2. SP6/T3 Polymerase
5.2.2.4.4. RNase Inhibitor
5.2.2.4.5. DNase
5.2.2.4.6. Others

5.2.2.5. Lipids & Formulation Materials

5.2.2.5.1. Ionizable Lipids
5.2.2.5.2. PEG-Lipids

5.2.2.6. Purification & Analytical Materials

Chapter 6. MRNA Synthesis Raw Materials Market Segmentation 2: By Grade Type, Estimates & Trend Analysis
6.1. Market Share by Grade Type, 2024 & 2034
6.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Grade Type:

6.2.1. Research Grade
6.2.2. GMP Grade

Chapter 7. MRNA Synthesis Raw Materials Market Segmentation 3: By Application, Estimates & Trend Analysis
7.1. Market Share by Application, 2024 & 2034
7.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:

7.2.1. Therapeutics Typeion
7.2.2. Vaccine Typeion
7.2.3. Others

Chapter 8. MRNA Synthesis Raw Materials Market Segmentation 4: By End-user, Estimates & Trend Analysis
8.1. Market Share by End-user, 2024 & 2034
8.2. Market Size (Value (US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End-user:

8.2.1. Biotechnology & Pharmaceutical Companies
8.2.2. CMOs & CROs
8.2.3. Research and Academic Institutes

Chapter 9. MRNA Synthesis Raw Materials Market Segmentation 5: Regional Estimates & Trend Analysis
9.1. Global MRNA Synthesis Raw Materials Market, Regional Snapshot 2024 & 2034
9.2. North America

9.2.1. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034

9.2.1.1. US
9.2.1.2. Canada

9.2.2. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.2.3. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.2.4. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.2.5. North America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034

9.3. Europe

9.3.1. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034

9.3.1.1. Germany
9.3.1.2. U.K.
9.3.1.3. France
9.3.1.4. Italy
9.3.1.5. Spain
9.3.1.6. Rest of Europe

9.3.2. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.3.3. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.3.4. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.3.5. Europe MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034

9.4. Asia Pacific

9.4.1. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034

9.4.1.1. India
9.4.1.2. China
9.4.1.3. Japan
9.4.1.4. Australia
9.4.1.5. South Korea
9.4.1.6. Hong Kong
9.4.1.7. Southeast Asia
9.4.1.8. Rest of Asia Pacific

9.4.2. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.4.3. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.4.4. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.4.5. Asia Pacific MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034

9.5. Latin America

9.5.1. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Country, 2021-2034

9.5.1.1. Brazil
9.5.1.2. Mexico
9.5.1.3. Rest of Latin America

9.5.2. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.5.3. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.5.4. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.5.5. Latin America MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034

9.6. Middle East & Africa

9.6.1. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by country, 2021-2034

9.6.1.1. GCC Countries
9.6.1.2. Israel
9.6.1.3. South Africa
9.6.1.4. Rest of Middle East and Africa

9.6.2. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Type, 2021-2034
9.6.3. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Grade Type, 2021-2034
9.6.4. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by Application, 2021-2034
9.6.5. Middle East & Africa MRNA Synthesis Raw Materials Market Revenue (US$ Mn) Estimates and Forecasts by End-user, 2021-2034

Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances

10.2. Company Profiles

10.2.1. Roche

10.2.1.1. Business Overview
10.2.1.2. Key Type/Service
10.2.1.3. Financial Performance
10.2.1.4. Geographical Presence
10.2.1.5. Recent Developments with Business Strategy

10.2.2. Thermo Fisher Scientific Inc
10.2.3. Creative Enzymes
10.2.4. Promega Corporation
10.2.5. Merck
10.2.6. BOC Sciences
10.2.7. Jena Bioscience GmbH
10.2.8. Aldevron
10.2.9. Sichuan Qingmu Pharmaceutical Co., Ltd
10.2.10. TriLink BioTechnologies
10.2.11. Creative Biogene
10.2.12. New England Biolabs
10.2.13. Other Prominent Players
10.2.13.1. Bio-Synthesis Inc.
10.2.13.2. Integrated DNA Technologies (IDT)
10.2.13.3. GenScript Biotech Corporation
10.2.13.4. Yeasen Biotechnology (Shanghai) Co., Ltd.
10.2.13.5. Eurogentec
10.2.13.6. Beijing SBS Genetech Co., Ltd.
10.2.13.7. Lucigen (LGC Biosearch Technologies)
10.2.13.8. BioCat GmbH
10.2.13.9. ATDBio Ltd.
10.2.13.10. Bio Basic Inc.
10.2.13.11. Sartorius AG
10.2.13.12. HONGENE
10.2.13.13. ArcticZymes Technologies

Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

mRNA Synthesis Raw Materials Market is expected to grow at a 6.6% CAGR during the forecast period for 2025 to 2034.

F. Hoffmann-La Roche Ltd., Jena Bioscience GmbH, Merck KGaA, Yeasen Biotechnology (Shanghai) Co., Ltd., BOC Sciences, Thermo Fisher Scientific, Inc.,

mRNA Synthesis Raw Materials Market Size is valued at USD 1.8 Bn in 2024 and is predicted to reach USD 3.4 Bn by the year 2034

mRNA synthesis raw materials market is segmented on the try, applications and end-use.

North American region is leading the mRNA Synthesis Raw Material Market.

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