Monolith Chromatography Columns for Advanced Therapeutics Market Size, Share Detailed Report 2025 to 2034

Report Id: 2558 Pages: 180 Last Updated: 02 January 2026 Format: PDF / PPT / Excel / Power BI
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Segmentation of Monolith Chromatography Columns for Advanced Therapeutics Market -

Monolith Chromatography Columns for Advanced Therapeutics Market by Product Type -

  • Analytical Monoliths                                
  • Preparative Monoliths                                           
  • Process-Scale Monolith                                      

Monolith Chromatography Columns for Advanced Therapeutics Mark

Monolith Chromatography Columns for Advanced Therapeutics Market by Material -

  • Silica Monoliths
  • Polymer Monoliths
  • Hybrid 

Monolith Chromatography Columns for Advanced Therapeutics Market by Technology

  • Affinity Chromatography                                      
  • Ion Exchange (IEX)                                     
  • Size Exclusion (SEC)                                
  • Hydrophobic Interaction (HIC)                                         
  • Others (Reversed-Phase, Multimodal, GC)

 Monolith Chromatography Columns for Advanced Therapeutics Market by Application -

  • Gene Therapy                               
    • AAV/lentiviral vector purification                                    
    • CRISPR payload isolation                                    
  • mRNA Therapeutics                                
    • LNP formulation polishing                                   
    • Plasmid DNA clearance                                       
  • Cell Therapies                                           
    • CAR-T cell processing                                           
    • Exosome harvesting                                
  • Vaccines                                         
    • Viral vector concentration                                   
    • Virus-like particle (VLP) purification                                            
  • Monoclonal Antibodies (High-capacity capture)                                  
  • Others (Phage Therapy, Protein and Peptide Therapeutics, Biomolecule Analysis, Water Purity Testing)

Monolith Chromatography Columns for Advanced Therapeutics Market by End-User

  • Pharma & biopharmaceuticals companies                                             
  • CDMOs                                            
  • Biotech Startups                                        

Monolith Chromatography Columns for Advanced Therapeutics Market by Region-

North America-

  • The US
  • Canada

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Mexico
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Snapshot

Chapter 4. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2025-2034
4.8. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Penetration & Growth Prospect Mapping (US$ Mn), 2024-2034
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2024)
4.10. Use/impact of AI on MONOLITH CHROMATOGRAPHY COLUMNS AND MEDIA FOR ADVANCED THERAPEUTICS MARKET Industry Trends

Chapter 5. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 1: By Material, Estimates & Trend Analysis
5.1. Market Share by Material, 2024 & 2034
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Material:

5.2.1. Polymer Monoliths
5.2.2. Silica Monoliths
5.2.3. Hybrid

Chapter 6. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 2: By Product Type, Estimates & Trend Analysis
6.1. Market Share by Product Type, 2024 & 2034
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Product Type:

6.2.1. Analytical Monoliths
6.2.2. Preparative Monoliths
6.2.3. Process-Scale Monolith

Chapter 7. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 3: By Technology, Estimates & Trend Analysis
7.1. Market Share by Technology, 2024 & 2034
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Technology:

7.2.1. Affinity Chromatography
7.2.2. Ion Exchange (IEX)
7.2.3. Size Exclusion (SEC)
7.2.4. Hydrophobic Interaction (HIC)
7.2.5. Others (Reversed-Phase, Multimodal, GC)

Chapter 8. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 4: By Application, Estimates & Trend Analysis
8.1. Market Share by Application, 2024 & 2034
8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:

8.2.1. Gene Therapy

8.2.1.1. AAV/lentiviral vector purification
8.2.1.2. CRISPR payload isolation

8.2.2. mRNA Therapeutics

8.2.2.1. LNP formulation polishing
8.2.2.2. Plasmid DNA clearance

8.2.3. Cell Therapies

8.2.3.1. CAR-T cell processing
8.2.3.2. Exosome harvesting

8.2.4. Vaccines

8.2.4.1. Viral vector concentration
8.2.4.2. Virus-like particle (VLP) purification

8.2.5. Monoclonal Antibodies (High-capacity capture)

8.2.6. Others (Phage Therapy, Protein and Peptide Therapeutics, Biomolecule Analysis, Water Purity Testing)

Chapter 9. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 5: By End-User, Estimates & Trend Analysis
9.1. Market Share by End-User, 2024 & 2034
9.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End-User:

9.2.1. Pharma & biopharmaceuticals companies
9.2.2. CDMOs
9.2.3. Biotech Startups

Chapter 10. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 6: Regional Estimates & Trend Analysis

10.1. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market, Regional Snapshot 2024 & 2034


10.2. North America
10.2.1. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
10.2.1.1. US
10.2.1.2. Canada
10.2.2. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.2.3. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.2.4. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.2.5. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.2.6. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034

10.3. Europe
10.3.1. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

10.3.1.1. Germany
10.3.1.2. U.K.
10.3.1.3. France
10.3.1.4. Italy
10.3.1.5. Spain
10.3.1.6. Rest of Europe

10.3.2. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.3.3. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.3.4. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.3.5. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.3.6. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034

10.4. Asia Pacific
10.4.1. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

10.4.1.1. India
10.4.1.2. China
10.4.1.3. Japan
10.4.1.4. Australia
10.4.1.5. South Korea
10.4.1.7. Southeast Asia
10.4.1.8. Rest of Asia Pacific

10.4.2. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.4.3. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.4.4. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.4.5. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts By Application, 2021-2034
10.4.6. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034

10.5. Latin America
10.5.1. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

10.5.1.1. Brazil
10.5.1.2. Mexico
10.5.1.3. Rest of Latin America

10.5.2. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.5.3. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.5.4. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.5.5. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.5.6. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034

10.6. Middle East & Africa
10.6.1. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034


10.6.1.1. GCC Countries
10.6.1.3. South Africa
10.6.1.4. Rest of Middle East and Africa


10.6.2. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.6.3. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.6.4. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.6.5. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.6.6. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034

Chapter 11. Competitive Landscape
11.1. Major Mergers and Acquisitions/Strategic Alliances
11.2. Company Profiles

Primary Manufacturers/Leaders

11.2.1.1. Sartorius BIA Separations
11.2.1.2. Merck Millipore (Merck KGaA, including Sigma-Aldrich)
11.2.1.3. Thermo Fisher Scientific (including Dionex)
11.2.1.4. Danaher (Phenomenex)
11.2.1.5. BioChromatographix International (BCI)
11.2.1.6. Bio-Rad Laboratories
11.2.1.7. Tantti
11.2.1.8. ACHIEVE CHEM

Supporting Suppliers/Partners

11.2.1.9. Agilent Technologies
11.2.1.10. Waters Corporation
11.2.1.11. Resonac
11.2.1.12. GL Sciences Inc.
11.2.1.13. Metrohm AG
11.2.1.14. JNC Corporation

Emerging or Niche Players

11.2.1.15. Sterogene Bioseparations
11.2.1.16. Princeton Chromatography Inc.
11.2.1.17. NanoMicro Technology

Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

Monolith Chromatography Columns for Advanced Therapeutics Market Size is valued at USD 286.1 Mn in 2024 and is predicted to reach USD 1,342.5 Mn by th

Monolith Chromatography Columns for Advanced Therapeutics Market is predicted to develop at an 17.0% CAGR during the forecast period for 2025-2034.

Sartorius (Bia separations), Agilent Technologies, Bio-Rad Laboratories, Showa Denko K. K., GL Sciences Inc., Metrohm AG, Waters Corporation

Monolith Chromatography Columns for Advanced Therapeutics Market is segmented by Monolithic Columns, technology, and end user.

North America region is leading the Monolith Chromatography Columns for Advanced Therapeutics Market

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