Global Monolith Chromatography Columns for Advanced Therapeutics Market Size is valued at USD 286.1 Mn in 2024 and is predicted to reach USD 1,342.5 Mn by the year 2034 at an 17.0% CAGR during the forecast period for 2025-2034.
Monoliths are porous rod formations distinguished by the existence of mesopores and macropores. These pores confer monoliths with elevated permeability, many channels, and an extensive surface area conducive to reactivity. Inquire of ChatGPT This market study includes monolith columns that are used in the small-scale analysis and quality control in laboratory settings, mid-scale purification tasks & large-volume columns tailored for industrial bioprocessing and Good Manufacturing Practice (GMP) for vaccine manufacturing, gene therapy production, and purification of viral vectors or mRNA, biomolecules such as proteins, peptides, and nucleic acids.
Monolith chromatography columns represent a specialized advancement in liquid chromatography, particularly in techniques like high-performance liquid chromatography (HPLC). Unlike traditional packed columns that consist of small beads of stationary phase material, monolith columns feature a singular, porous rod-like structure with interconnected channels and pores. This unique design offers several distinct advantages over packed columns.
Monolith columns offer higher permeability and lower backpressure, enabling faster separations at higher flow rates, boosting throughput in chromatographic analyses. Their larger surface area and enhanced binding capacity improve resolution and loading efficiency, ideal for separating complex mixtures. Additionally, monolith columns are less prone to clogging from complex sample matrices due to their interconnected pore structure. This feature ensures consistent performance over extended periods, making them reliable for both routine analyses and rigorous purification processes.
The global Monolith Chromatography Columns for Advanced Therapeutics Market is experiencing growth driven by the rising need for faster and more efficient liquid chromatography techniques. This demand is primarily fueled by the rapid development of new drugs, biotherapeutics, and other high-value products. Monolith columns are particularly favored for their capability to achieve high-throughput separations and effectively handle complex samples, making them highly attractive in these critical application areas.
The Monolith Chromatography Columns for Advanced Therapeutics Market is segmented by Monolithic Columns, technology, and end user. The Product Type segment includes Analytical Monoliths, Preparative Monoliths, Process-Scale Monoliths. Whereas the Material segment comprises Polymer Monoliths, Silica Monoliths, and Hybrid. By Technology, the market is categorised into Affinity Chromatography, Ion Exchange (IEX), Size Exclusion (SEC), Hydrophobic Interaction (HIC), Others – Reversed-Phase, Multimodal, GC. By Application, the segmentation consists of Gene Therapy – AAV/lentiviral vector purification, CRISPR payload isolation; mRNA Therapeutics – LNP formulation polishing, Plasmid DNA clearance; Cell Therapies – CAR-T cell processing, Exosome harvesting; Vaccines – Viral vector concentration, VLP purification; Monoclonal Antibodies – High-capacity capture; Others – Phage Therapy, Protein and Peptide Therapeutics, Biomolecule Analysis, Water Purity Testing). At the last, by End User, the market includes Pharma & Biopharmaceutical Companies, CDMOs, Biotech Startups.
The silica monolith chromatography column segment is driving growth in the global market for several reasons. These columns offer superior performance over traditional packed columns with higher permeability and lower backpressure, enabling faster separations at higher flow rates. Their larger surface area and binding capacity enhance resolution and loading capacity, while the monolithic structure reduces susceptibility to clogging from complex sample matrices. Continuous technological advancements have further improved separation efficiency and peak symmetry. Manufacturers like Waters Corporation have invested significantly in optimizing these technologies, expanding their applications and performance capabilities. This aligns well with market demands from pharmaceutical, biotechnology, and other industries seeking faster and more efficient liquid chromatography techniques to support the rapid development of new drugs, biotherapeutics, and high-value products.
North America stands out as the leading region in the global Monolith Chromatography Columns for Advanced Therapeutics Market for several compelling reasons. With the largest market size in the overall chromatography columns market as of 2023, North America benefits from a robust pharmaceutical industry that extensively employs HPLC and monolith columns for drug development, quality control, and characterization processes. Key players in chromatography, such as Waters Corporation, which manufactures silica-based monolith columns, are headquartered in North America, contributing to the region's leadership in innovation and technological advancement.
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Report Attribute |
Specifications |
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Market Size Value In 2024 |
USD 286.1 Mn |
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Revenue Forecast In 2034 |
USD 1,342.5 Mn |
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Growth Rate CAGR |
CAGR of 17.0 % from 2025 to 2034 |
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Quantitative Units |
Representation of revenue in US$ Bn and CAGR from 2025 to 2034 |
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Historic Year |
2021 to 2024 |
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Forecast Year |
2025-2034 |
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Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
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Segments Covered |
By Product Type, Materials, By Technology, By Application, By End-Users and By Region |
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Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
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Country Scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South Korea; Southeast Asia |
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Competitive Landscape |
Sartorius BIA Separations, Merck Millipore (Merck KGaA, including Sigma-Aldrich), Thermo Fisher Scientific (including Dionex), Danaher (Phenomenex), BioChromatographix International (BCI), Bio-Rad Laboratories, Tantti, ACHIEVE CHEM, Agilent Technologies, Waters Corporation, Resonac, GL Sciences Inc., Metrohm AG, JNC Corporation, Sterogene Bioseparations, Princeton Chromatography Inc., and NanoMicro Technology. |
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Customization Scope |
Free customization report with the procurement of the report, Modifications to the regional and segment scope. Geographic competitive landscape. |
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Pricing and Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Snapshot
Chapter 4. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2025-2034
4.8. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market Penetration & Growth Prospect Mapping (US$ Mn), 2024-2034
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2024)
4.10. Use/impact of AI on MONOLITH CHROMATOGRAPHY COLUMNS AND MEDIA FOR ADVANCED THERAPEUTICS MARKET Industry Trends
Chapter 5. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 1: By Material, Estimates & Trend Analysis
5.1. Market Share by Material, 2024 & 2034
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Material:
5.2.1. Polymer Monoliths
5.2.2. Silica Monoliths
5.2.3. Hybrid
Chapter 6. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 2: By Product Type, Estimates & Trend Analysis
6.1. Market Share by Product Type, 2024 & 2034
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Product Type:
6.2.1. Analytical Monoliths
6.2.2. Preparative Monoliths
6.2.3. Process-Scale Monolith
Chapter 7. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 3: By Technology, Estimates & Trend Analysis
7.1. Market Share by Technology, 2024 & 2034
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Technology:
7.2.1. Affinity Chromatography
7.2.2. Ion Exchange (IEX)
7.2.3. Size Exclusion (SEC)
7.2.4. Hydrophobic Interaction (HIC)
7.2.5. Others (Reversed-Phase, Multimodal, GC)
Chapter 8. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 4: By Application, Estimates & Trend Analysis
8.1. Market Share by Application, 2024 & 2034
8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:
8.2.1. Gene Therapy
8.2.1.1. AAV/lentiviral vector purification
8.2.1.2. CRISPR payload isolation
8.2.2. mRNA Therapeutics
8.2.2.1. LNP formulation polishing
8.2.2.2. Plasmid DNA clearance
8.2.3. Cell Therapies
8.2.3.1. CAR-T cell processing
8.2.3.2. Exosome harvesting
8.2.4. Vaccines
8.2.4.1. Viral vector concentration
8.2.4.2. Virus-like particle (VLP) purification
8.2.5. Monoclonal Antibodies (High-capacity capture)
8.2.6. Others (Phage Therapy, Protein and Peptide Therapeutics, Biomolecule Analysis, Water Purity Testing)
Chapter 9. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 5: By End-User, Estimates & Trend Analysis
9.1. Market Share by End-User, 2024 & 2034
9.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End-User:
9.2.1. Pharma & biopharmaceuticals companies
9.2.2. CDMOs
9.2.3. Biotech Startups
Chapter 10. Monolith Chromatography Columns and Media for Advanced Therapeutics Market Segmentation 6: Regional Estimates & Trend Analysis
10.1. Global Monolith Chromatography Columns and Media for Advanced Therapeutics Market, Regional Snapshot 2024 & 2034
10.2. North America
10.2.1. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
10.2.1.1. US
10.2.1.2. Canada
10.2.2. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.2.3. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.2.4. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.2.5. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.2.6. North America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034
10.3. Europe
10.3.1. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
10.3.1.1. Germany
10.3.1.2. U.K.
10.3.1.3. France
10.3.1.4. Italy
10.3.1.5. Spain
10.3.1.6. Rest of Europe
10.3.2. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.3.3. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.3.4. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.3.5. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.3.6. Europe Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034
10.4. Asia Pacific
10.4.1. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
10.4.1.1. India
10.4.1.2. China
10.4.1.3. Japan
10.4.1.4. Australia
10.4.1.5. South Korea
10.4.1.7. Southeast Asia
10.4.1.8. Rest of Asia Pacific
10.4.2. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.4.3. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.4.4. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.4.5. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts By Application, 2021-2034
10.4.6. Asia Pacific Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034
10.5. Latin America
10.5.1. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
10.5.1.1. Brazil
10.5.1.2. Mexico
10.5.1.3. Rest of Latin America
10.5.2. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.5.3. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.5.4. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.5.5. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.5.6. Latin America Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034
10.6. Middle East & Africa
10.6.1. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
10.6.1.1. GCC Countries
10.6.1.3. South Africa
10.6.1.4. Rest of Middle East and Africa
10.6.2. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Material, 2021-2034
10.6.3. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
10.6.4. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Technology, 2021-2034
10.6.5. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
10.6.6. Middle East & Africa Monolith Chromatography Columns and Media for Advanced Therapeutics Market Revenue (US$ Million) Estimates and Forecasts by End-User, 2021-2034
Chapter 11. Competitive Landscape
11.1. Major Mergers and Acquisitions/Strategic Alliances
11.2. Company Profiles
Primary Manufacturers/Leaders
11.2.1.1. Sartorius BIA Separations
11.2.1.2. Merck Millipore (Merck KGaA, including Sigma-Aldrich)
11.2.1.3. Thermo Fisher Scientific (including Dionex)
11.2.1.4. Danaher (Phenomenex)
11.2.1.5. BioChromatographix International (BCI)
11.2.1.6. Bio-Rad Laboratories
11.2.1.7. Tantti
11.2.1.8. ACHIEVE CHEM
Supporting Suppliers/Partners
11.2.1.9. Agilent Technologies
11.2.1.10. Waters Corporation
11.2.1.11. Resonac
11.2.1.12. GL Sciences Inc.
11.2.1.13. Metrohm AG
11.2.1.14. JNC Corporation
Emerging or Niche Players
11.2.1.15. Sterogene Bioseparations
11.2.1.16. Princeton Chromatography Inc.
11.2.1.17. NanoMicro Technology
Monolith Chromatography Columns for Advanced Therapeutics Market by Product Type -
Monolith Chromatography Columns for Advanced Therapeutics Market by Material -
Monolith Chromatography Columns for Advanced Therapeutics Market by Technology
Monolith Chromatography Columns for Advanced Therapeutics Market by Application -
Monolith Chromatography Columns for Advanced Therapeutics Market by End-User
Monolith Chromatography Columns for Advanced Therapeutics Market by Region-
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
To know more about the research methodology used for this study, kindly contact us/click here.
