Oligonucleotide Synthesis, Modification, and Purification Services Market Size, Share & Trends Analysis Report By Product (Primers, Probes, DNA Oligos, RNA Oligos, Others), By Application (Therapeutic Applications (Neurological Disorders, Rare Diseases, Other Diseases), Research Applications (PCR, Sequencing, Other Research Applications), Diagnostic Applications), Type, End-users, By Region, And By Segment Forecasts, 2025-2034

Report Id: 1293 Pages: 180 Last Updated: 21 April 2025 Format: PDF / PPT / Excel / Power BI
Share With : linkedin twitter facebook

Segmentation of Oligonucleotide Synthesis, Modification, and Purification Services Market

Oligonucleotide Synthesis, Modification, and Purification Services Market- by Product

  • Primers
  • Probes
  • DNA Oligos
    • Molecular Beacons
    • Randomer Oligos
    • Unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) Oligos
    • Others (Light-activated Oligos, Chimeric Oligos and Trimers Mixes)
  • RNA Oligos
    • Single Guide RNA (sgRNA)
    • Small Interfering RNA (siRNA)
    • MicroRNA (miRNA)
    • Antisense Oligo (ASO)
    • Sequencing Primers
    • Aptamers
    • Others (Long RNA, etc.)
  • Others

oligonucleotide

Oligonucleotide Synthesis, Modification, and Purification Services Market- Application

  • Therapeutic Applications
    • Neurological Disorders
    • Rare Diseases
    • Other Diseases
  • Research Applications
    • PCR
    • Sequencing
    • Other Research Applications
  • Diagnostic Applications

Oligonucleotide Synthesis, Modification, and Purification Services Market- Type      

  • Customized Oligos
  • Predesigned Oligos
  • Reagents & Consumables
  • Equipment

Oligonucleotide Synthesis, Modification, and Purification Services Market- End-users      

  • Hospitals
  • Pharmaceutical & Biotechnology Companies
  • Diagnostic Laboratories
  • CROs and CMOs
  • Academic Research Institutes

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,

  • U.S.
  • Canada

Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 

  • Germany
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe

Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,

  • India
  • China
  • Japan
  • South Korea
  • Australia & New Zealand

Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 

  • Brazil
  • Mexico
  • Rest of Latin America

Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 

  • GCC Countries
  • South Africa
  • Rest of Middle East & Africa
  • Company Overview
  • Financial Performance
  • Key Development

Chapter 1.          Methodology and Scope

1.1.        Research Methodology

1.2.        Research Scope & Assumptions

Chapter 2.          Executive Summary

Chapter 3.          Global Oligonucleotide Synthesis, Modification, and Purification Services Market Snapshot

Chapter 4.          Global Oligonucleotide Synthesis, Modification, and Purification Services Market Variables, Trends & Scope

4.1.        Market Segmentation & Scope

4.2.        Drivers

4.3.        Challenges

4.4.        Trends

4.5.        Investment and Funding Analysis

4.6.        Porter's Five Forces Analysis

4.7.        Incremental Opportunity Analysis (US$ MN), 2024-2031

4.8.        Global Oligonucleotide Synthesis, Modification, and Purification Services Market Penetration & Growth Prospect Mapping (US$ Mn), 2023-2031

4.9.        Competitive Landscape & Market Share Analysis, By Key Player (2023)

4.10.     Use/impact of AI on OLIGONUCLEOTIDE SYNTHESIS, MODIFICATION, AND PURIFICATION SERVICES MARKET Industry Trends

Chapter 5.          Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 1: By Product, Estimates & Trend Analysis

5.1.        Market Share by Product, 2024 & 2034

5.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Product:

5.2.1.    Primers

5.2.2.    Probes

5.2.3.    DNA Oligos

5.2.3.1. Molecular Beacons

5.2.3.2. Randomer Oligos

5.2.3.3. Unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) Oligos

5.2.3.4. Others (Light-activated Oligos, Chimeric Oligos and Trimers Mixes)

5.2.4.    RNA Oligos

5.2.4.1. Single Guide RNA (sgRNA)

5.2.4.2. Small Interfering RNA (siRNA)

5.2.4.3. MicroRNA (miRNA)

5.2.4.4. Antisense Oligo (ASO)

5.2.4.5. Sequencing Primers

5.2.4.6. Aptamers

5.2.4.7. Others (Long RNA, etc.)

5.2.5.    Others

Chapter 6.          Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 2: By Application, Estimates & Trend Analysis

6.1.        Market Share by Application, 2024 & 2034

6.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:

6.2.1.    Therapeutic Applications

6.2.1.1. Neurological Disorders

6.2.1.2. Rare Diseases

6.2.1.3. Other Diseases

6.2.2.    Research Applications

6.2.2.1. PCR

6.2.2.2. Sequencing

6.2.2.3. Other Research Applications

6.2.3.    Diagnostic Applications

Chapter 7.          Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 3: By Type, Estimates & Trend Analysis

7.1.        Market Share by Type, 2024 & 2034

7.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Type:

7.2.1.    Customized Oligos

7.2.2.    Predesigned Oligos

7.2.3.    Reagents & Consumables

7.2.4.    Equipment

Chapter 8.          Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 4: By End User, Estimates & Trend Analysis

8.1.        Market Share by End User, 2024 & 2034

8.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End User:

8.2.1.    Hospitals

8.2.2.    Pharmaceutical & Biotechnology Companies

8.2.3.    Diagnostic Laboratories

8.2.4.    CROs and CMOs

8.2.5.    Academic Research Institutes

Chapter 9.          Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 5: Regional Estimates & Trend Analysis

9.1.        Global Oligonucleotide Synthesis, Modification, and Purification Services Market, Regional Snapshot 2024 & 2034

9.2.        North America

9.2.1.    North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.2.1.1. US

9.2.1.2. Canada

9.2.2.    North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034

9.2.3.    North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034

9.2.4.    North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.2.5.    North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034

9.3.        Europe

9.3.1.    Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.3.1.1. Germany

9.3.1.2. U.K.

9.3.1.3. France

9.3.1.4. Italy

9.3.1.5. Spain

9.3.1.6. Rest of Europe

9.3.2.    Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034

9.3.3.    Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034

9.3.4.    Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.3.5.    Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034

9.4.        Asia Pacific

9.4.1.    Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.4.1.1. India

9.4.1.2. China

9.4.1.3. Japan

9.4.1.4. Australia

9.4.1.5. South Korea

9.4.1.6. Hong Kong

9.4.1.7. Southeast Asia

9.4.1.8. Rest of Asia Pacific

9.4.2.    Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034

9.4.3.    Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034

9.4.4.    Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts By Type, 2021-2034

9.4.5.    Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034

9.5.        Latin America

9.5.1.    Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034

9.5.1.1. Brazil

9.5.1.2. Mexico

9.5.1.3. Rest of Latin America

9.5.2.    Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034

9.5.3.    Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034

9.5.4.    Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.5.5.    Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034

9.6.        Middle East & Africa

9.6.1.    Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034

9.6.1.1. GCC Countries

9.6.1.2. Israel

9.6.1.3. South Africa

9.6.1.4. Rest of Middle East and Africa

9.6.2.    Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034

9.6.3.    Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034

9.6.4.    Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034

9.6.5.    Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034

Chapter 10.        Competitive Landscape

10.1.     Major Mergers and Acquisitions/Strategic Alliances

10.2.     Company Profiles

10.2.1.  Agilent Technologies

10.2.1.1.             Business Overview

10.2.1.2.             Key Product/Service Type

10.2.1.3.             Financial Performance

10.2.1.4.             Geographical Presence

10.2.1.5.             Recent Developments with Business Strategy

10.2.2.  Ajinomoto Bio-Pharma Services

10.2.3.  CordenPharma

10.2.4.  Integrated DNA Technologies

10.2.5.  Kaneka Eurogentec

10.2.6.  LGC Biosearch Technologies

10.2.7.  Microsynth

10.2.8.  Merck KGaA

10.2.9.  Nitto Avecia

10.2.10.              Thermo Fisher Scientific

10.2.11.              TriLink BioTechnologies

10.2.12.              Creative Biolabs

10.2.13.              Ella Biotech

10.2.14.              Eurofins Scientific

10.2.15.              Ribo Biotechnology

10.2.16.              WuXi AppTec

10.2.17.              GE Healthcare

10.2.18.              Bio-synthesis Inc.

10.2.19.              Almac Group

10.2.20.              Sumitomo Chemical

10.2.21.              BioSpring

10.2.22.              ChemGenes

10.2.23.              BianoScience GmbH

10.2.24.              ATDBio Ltd

10.2.25.              Burkert UK Limited

10.2.26.              IBA Lifesciences GmbH

10.2.27.              Other Market Players

 

Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

Name field cannot be blank!
Email field cannot be blank!(Use email format)
Designation field cannot be blank!
Company field cannot be blank!
Contact No field cannot be blank!
Message field cannot be blank!
1537
Security Code field cannot be blank!

Frequently Asked Questions

Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, Cord

Oligonucleotide Synthesis, Modification, and Purification Services Market Size is valued at USD 4.69 billion in 2024 and is predicted to reach USD 12.

The Oligonucleotide Synthesis, Modification, and Purification Services Market is expected to grow at a 10.02% CAGR during the forecast period for 2025

Oligonucleotide Synthesis, Modification, and Purification Services Market is segmented into product, application, type, and end-users.

North America region is leading the Oligonucleotide Synthesis, Modification, and Purification Services Market.
Get Sample Report Enquiry Before Buying