Oligonucleotide Synthesis, Modification, and Purification Services Market Size is valued at USD 4.69 billion in 2024 and is predicted to reach USD 12.27 billion by the year 2034 at a 10.02% CAGR during the forecast period for 2025-2034.
Key Industry Insights & Findings from the Report:
Synthetic DNA oligonucleotides are applied in a wide range of applications, from fundamental research to clinical diagnostics and biotherapeutics. Oligonucleotides are chemically synthesized molecular chains from nucleosides. Solid-phase synthesis is the most popular method used for oligonucleotides chemical synthesis. They have a variety of uses in biology, biochemistry, molecular diagnostics, genomics, forensics, and others. Selecting the suitable oligonucleotide synthesizer for application is critical to optimizing product quality while maintaining cost-effectiveness.
The primary elements boosting the growth of the oligonucleotide synthesis, modification, and purification services market include increasing demand for oligonucleotides, growing preference of patients toward personalized medicines, rising collaborations and mergers/acquisitions by manufacturers, and growing older population, and the high prevalence of chronic diseases. Apart from this, the need for high-quality oligos is increasing due to the increase in R&D activities. Therefore, biotech and pharmaceutical companies' increasing research and development activities to treat various viral infections, chronic diseases, and genetic disorders are expected to fuel market growth over the forecast years.
For instance, in July 2017, Nitto Denko Avecia Inc. (Avecia) opened a new oligonucleotide API manufacturing facility in Milford, MA. The expansion has added 20,000 sq. ft. of manufacturing and office space at the site and provided CGMP oligonucleotide manufacturing capacity up to 1.8 mol, bringing the site capacity to 3.0 mol. Also, this expansion has helped Avecia's clients to receive timely oligonucleotide API to advance their drug development programs in clinical trials. However, the low-quality oligonucleotide sequences, lack of technical requirements, and the complexities associated with the oligonucleotide synthesis may hamper the market growth.
The Oligonucleotide Synthesis, Modification, and Purification Services Market is segmented into product, application, type, and end-users. By product, it includes primers, probes, and DNA oligos, such as molecular beacons, randomer oligos, and more specialized variants like unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) oligos, as well as other categories such as light-activated oligos and chimeric oligos. RNA oligos encompass single guide RNA (sgRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligos (ASO), sequencing primers, and aptamers. Applications include therapeutic uses for conditions like neurological disorders, rare diseases, and other medical conditions, alongside research applications in PCR, sequencing, and diagnostics. The market is further divided by types into customized oligos, predesigned oligos, reagents & consumables, and equipment. End-users span across hospitals, pharmaceutical and biotechnology companies, diagnostic laboratories, CROs and CMOs, and academic research institutes.
The market is being examined throughout North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa. Due to increased R&D investments in pharma and biotech businesses to enhance oligonucleotide production and synthesis processes, North America is likely to have the largest share of this market throughout the forecast years, followed by Europe.
| Report Attribute | Specifications |
| Market Size Value In 2024 | USD 4.69 Bn |
| Revenue Forecast In 2034 | USD 12.27 Bn |
| Growth Rate CAGR | CAGR of 10.02% from 2025 to 2034 |
| Quantitative Units | Representation of revenue in US$ Billion and CAGR from 2025 to 2034 |
| Historic Year | 2021 to 2024 |
| Forecast Year | 2025-2034 |
| Report Coverage | The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
| Segments Covered | By Product, Application, Type, and End-User |
| Regional Scope | North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
| Country Scope | U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico ; France; Italy; Spain; South Korea; South East Asia |
| Competitive Landscape | Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players |
| Customization Scope | Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape. |
| Pricing And Available Payment Methods | Explore pricing alternatives that are customized to your particular study requirements. |
Oligonucleotide Synthesis, Modification, and Purification Services Market- by Product
Oligonucleotide Synthesis, Modification, and Purification Services Market- Application
Oligonucleotide Synthesis, Modification, and Purification Services Market- Type
Oligonucleotide Synthesis, Modification, and Purification Services Market- End-users
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region,
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
This study employed a multi-step, mixed-method research approach that integrates:
This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.
Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.
Secondary data for the market study was gathered from multiple credible sources, including:
These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.
Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.
Primary interviews for this study involved:
Interviews were conducted via:
Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.
All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.
The data validation process included:
This ensured that the dataset used for modelling was clean, robust, and reliable.
The bottom-up approach involved aggregating segment-level data, such as:
This method was primarily used when detailed micro-level market data were available.
The top-down approach used macro-level indicators:
This approach was used for segments where granular data were limited or inconsistent.
To ensure accuracy, a triangulated hybrid model was used. This included:
This multi-angle validation yielded the final market size.
Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.
Given inherent uncertainties, three scenarios were constructed:
Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.