Global Oligonucleotide Synthesis, Modification, and Purification Services Market

Report ID : 1293 | Published : 2022-08-10 | Pages: 186 | Format: PDF/EXCEL

The global oligonucleotide synthesis, modification, and purification services market size was accounted at US$ 1.56 Bn in 2021; It is projected to grow at a compound annual growth rate (CAGR) of 17.50% from 2022 to 2030. Synthetic DNA oligonucleotides are applied in a wide range of applications, from fundamental research to clinical diagnostics and biotherapeutics. Oligonucleotides are chemically synthesized molecular chains from nucleosides. Solid-phase synthesis is the most popular method used for oligonucleotides chemical synthesis. They have a variety of uses in biology, biochemistry, molecular diagnostics, genomics, forensics, and others. Selecting the suitable oligonucleotide synthesizer for application is critical to optimizing product quality while maintaining cost-effectiveness.

The primary elements boosting the growth of the oligonucleotide synthesis, modification, and purification services market include increasing demand for oligonucleotides, growing preference of patients toward personalized medicines, rising collaborations and mergers/acquisitions by manufacturers, and growing older population, and the high prevalence of chronic diseases. Apart from this, the need for high-quality oligos is increasing due to the increase in R&D activities. Therefore, biotech and pharmaceutical companies' increasing research and development activities to treat various viral infections, chronic diseases, and genetic disorders are expected to fuel market growth over the forecast years. For instance, in July 2017, Nitto Denko Avecia Inc. (Avecia) opened a new oligonucleotide API manufacturing facility in Milford, MA. The expansion has added 20,000 sq. ft. of manufacturing and office space at the site and provided CGMP oligonucleotide manufacturing capacity up to 1.8 mol, bringing the site capacity to 3.0 mol. Also, this expansion has helped Avecia's clients to receive timely oligonucleotide API to advance their drug development programs in clinical trials. However, the low-quality oligonucleotide sequences, lack of technical requirements, and the complexities associated with the oligonucleotide synthesis may hamper the market growth.

The oligonucleotide synthesis, modification, and purification services market is classified based on oligonucleotide mfg. Types, applications, operation scale, therapeutic areas, end-users, and region. By oligonucleotide mfg. Types, the market comprises antisense oligonucleotides, siRNA, miRNA, and other oligonucleotides. The antisense oligonucleotides segment is anticipated to hold the highest market share over the forecast period owing to the increasing demand for oligonucleotides. The market is grouped into research and diagnostic, therapeutic, and contract manufacturing (OEM) in terms of applications. The research and diagnostic segment are expected to dominate this market in the near future due to the increasing novel diagnostic and therapeutic applications for oligos. The operation scale segment is divided into large-scale oligonucleotide synthesis, intermediate-scale oligonucleotide synthesis, and small-scale oligonucleotide synthesis. By therapeutic areas, the market is segmented into oncological disorders, eye disorders, metabolic disorders, autoimmune disorders, and other therapeutic areas. The oncological disorders would be the fastest-growing segment of this market in the coming days owing to the rising incidence of Cancer and the rising geriatric population. By end-users, the market is classified into pharmaceutical & biotechnology companies, hospitals & diagnostic laboratories, Contract research organizations (CROs) and contract manufacturing organizations (CMOs), and academic research institutes. The market is being examined throughout North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa. Due to increased R&D investments in pharma and biotech businesses to enhance oligonucleotide production and synthesis processes, North America is likely to have the largest share of this market throughout the forecast years, followed by Europe.

Some of the essential players operating in the oligonucleotide synthesis, modification, and purification services market are Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players.

Companies Mentioned

  • Ajinomoto Bio-Pharma Services
  • Integrated DNA Technologies
  • Kaneka Eurogentec
  • LGC Biosearch Technologies
  • Microsynth
  • MilliporeSigma
  • BioSpring
  • CordenPharma
  • Nitto Denko Avecia
  • TriLink Biotechnologies
  • Eurofins Scientific SE
  • Thermo Fisher Scientific Inc.
  • Agilent Technologies, Inc.
  • GE Healthcare
  • GeneDesign, Inc.
  • Bio-synthesis Inc.
  • ATDBio Ltd
  • Burkert UK Limited
  • Almac Group

Other Prominent Players

Chapter 1. Methodology and Scope

1.1. Research Methodology

1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Oligonucleotide Synthesis, Modification and Purification Services Market Snapshot

Chapter 4. Global Oligonucleotide Synthesis, Modification and Purification Services Market Variables, Trends & Scope

4.1. Market Segmentation & Scope

4.2. Drivers

4.3. Challenges

4.4. Trends

4.5. Industry Analysis – Porter’s Five Forces Analysis

4.6. Competitive Landscape & Market Share Analysis

4.7. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: By Oligonucleotide mfg. Types, Estimates & Trend Analysis

5.1. By Oligonucleotide mfg. Types, & Market Share, 2020 & 2030

5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Oligonucleotide mfg. Types:

5.2.1. Antisense Oligonucleotides

5.2.2. siRNA

5.2.3. miRNA

5.2.4. Other Oligonucleotides

Chapter 6. Market Segmentation 2: By Applications Estimates & Trend Analysis

6.1. By Applications & Market Share, 2020 & 2030

6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Applications:

6.2.1. Research and Diagnostic

6.2.2. Therapeutic

6.2.3. Contract Manufacturing (OEM)

Chapter 7. Market Segmentation 3: By Operation Scale Estimates & Trend Analysis

7.1. By Operation Scale & Market Share, 2020 & 2030

7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Operation Scale:

7.2.1. Large-Scale Oligonucleotide Synthesis

7.2.2. Intermediate-Scale Oligonucleotide Synthesis

7.2.3. Small-Scale Oligonucleotide Synthesis

Chapter 8. Market Segmentation 4: By Therapeutic Areas Estimates & Trend Analysis

8.1. By Therapeutic Areas & Market Share, 2020 & 2030

8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Therapeutic Areas:

8.2.1. Oncological Disorders

8.2.2. Eye Disorders

8.2.3. Metabolic Disorders

8.2.4. Autoimmune Disorders

8.2.5. Other Therapeutic Areas

Chapter 9. Market Segmentation 5: By End-Users Estimates & Trend Analysis

9.1. By End-Users & Market Share, 2020 & 2030

9.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By End-Users

9.2.1. Pharmaceutical & Biotechnology Companies

9.2.2. Hospitals & Diagnostic Laboratories

9.2.3. CROs and CMOs

9.2.4. Academic Research Institutes

Chapter 10. Oligonucleotide Synthesis, Modification and Purification Services Market Segmentation 6: Regional Estimates & Trend Analysis

10.1. North America

10.1.1. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Oligonucleotide mfg. Types, 2019-2030

10.1.2. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Applications, 2019-2030

10.1.3. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Operation Scale, 2019-2030

10.1.4. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Therapeutic Areas, 2019-2030

10.1.5. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by End-Users, 2019-2030

10.1.6. North America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by country, 2019-2030

10.2. Europe

10.2.1. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Oligonucleotide mfg. Types, 2019-2030

10.2.2. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Applications, 2019-2030

10.2.3. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Operation Scale, 2019-2030

10.2.4. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Therapeutic Areas, 2019-2030

10.2.5. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by End-Users, 2019-2030

10.2.6. Europe Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) by country, 2019-2030

10.3. Asia Pacific

10.3.1. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Oligonucleotide mfg. Types, 2019-2030

10.3.2. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Applications, 2019-2030

10.3.3. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Operation Scale, 2019-2030

10.3.4. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Therapeutic Areas, 2019-2030

10.3.5. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by End-Users, 2019-2030

10.3.6. Asia Pacific Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) by country, 2019-2030

10.4. Latin America

10.4.1. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Oligonucleotide mfg. Types, 2019-2030

10.4.2. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Applications, 2019-2030

10.4.3. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Operation Scale, 2019-2030

10.4.4. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Therapeutic Areas, 2019-2030

10.4.5. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by End-Users, 2019-2030

10.4.6. Latin America Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) by country, 2019-2030

10.5. Middle East & Africa

10.5.1. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Oligonucleotide mfg. Types, 2019-2030

10.5.2. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Applications, 2019-2030

10.5.3. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) By Operation Scale, 2019-2030

10.5.4. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts By Therapeutic Areas, 2019-2030

10.5.5. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) estimates and forecasts by End-Users, 2019-2030

10.5.6. Middle East & Africa Oligonucleotide Synthesis, Modification and Purification Services Market revenue (US$ Million) by country, 2019-2030

Chapter 11. Competitive Landscape

11.1. Major Mergers and Acquisitions/Strategic Alliances

11.2. Company Profiles 

11.2.1. Ajinomoto Bio-Pharma Services

11.2.2. Integrated DNA Technologies

11.2.3. Kaneka Eurogentec

11.2.4. Axolabs (LGC Group)

11.2.5. Microsynth

11.2.6. MilliporeSigma

11.2.7. BioSpring

11.2.8. CordenPharma

11.2.9. Nitto Denko Avecia

11.2.10. TriLink Biotechnologies

11.2.11. Eurofins Scientific SE

11.2.12. Thermo Fisher Scientific Inc.

11.2.13. Agilent Technologies, Inc.

11.2.14. GE Healthcare

11.2.15. GeneDesign, Inc.

11.2.16. Bio-synthesis Inc.

11.2.17. ATDBio Ltd

11.2.18. Burkert UK Limited

11.2.19. IBA Lifesciences GmbH

11.2.20. BianoScience GmbH

11.2.21. Sumitomo Chemical

11.2.22. ChemGenes

11.2.23. Almac Group

11.2.24. Other Prominent Players

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by By Oligonucleotide mfg. Types, 2020-2030 (Value US$ Mn)

  • Antisense Oligonucleotides
  • siRNA
  • miRNA
  • Other Oligonucleotides

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Applications, 2020-2030 (Value US$ Mn)

  • Research and Diagnostic
  • Therapeutic
  • Contract Manufacturing (OEM)

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Operation Scale, 2020-2030 (Value US$ Mn)

  • Large-Scale Oligonucleotide Synthesis
  • Intermediate-Scale Oligonucleotide Synthesis
  • Small-Scale Oligonucleotide Synthesis

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Therapeutic Areas, 2020-2030 (Value US$ Mn)

  • Oncological Disorders
  • Eye Disorders
  • Metabolic Disorders
  • Autoimmune Disorders
  • Other Therapeutic Areas

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by End-Users, 2020-2030 (Value US$ Mn)

  • Pharmaceutical & Biotechnology Companies
  • Hospitals & Diagnostic Laboratories
  • Contract research organisations (CROs) and contract manufacturing organisations (CMOs)
  • Academic Research Institutes

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 2020-2030 (Value US$ Mn)

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2020-2030 (Value US$ Mn)

  • U.S.
  • Canada

Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2020-2030 (Value US$ Mn)

  • Germany
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe

Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2020-2030 (Value US$ Mn)

  • India
  • China
  • Japan
  • South Korea
  • Australia & New Zealand

Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2020-2030 (Value US$ Mn)

  • Brazil
  • Mexico
  • Rest of Latin America

Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2020-2030 (Value US$ Mn)

  • GCC Countries
  • South Africa
  • Rest of Middle East & Africa

Competitive Landscape

  • Company Overview
  • Financial Performance
  • Key Development

Latest Strategic Developments

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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Market size was accounted at USD 1.56 Bn in 2021

annual growth rate (CAGR) of 17.50% from 2022 to 2030.

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