Oligonucleotide Synthesis, Modification, and Purification Services Market Size is valued at USD 4.69 billion in 2024 and is predicted to reach USD 12.27 billion by the year 2034 at a 10.02% CAGR during the forecast period for 2025-2034.
Key Industry Insights & Findings from the Report:
Synthetic DNA oligonucleotides are applied in a wide range of applications, from fundamental research to clinical diagnostics and biotherapeutics. Oligonucleotides are chemically synthesized molecular chains from nucleosides. Solid-phase synthesis is the most popular method used for oligonucleotides chemical synthesis. They have a variety of uses in biology, biochemistry, molecular diagnostics, genomics, forensics, and others. Selecting the suitable oligonucleotide synthesizer for application is critical to optimizing product quality while maintaining cost-effectiveness.
The primary elements boosting the growth of the oligonucleotide synthesis, modification, and purification services market include increasing demand for oligonucleotides, growing preference of patients toward personalized medicines, rising collaborations and mergers/acquisitions by manufacturers, and growing older population, and the high prevalence of chronic diseases. Apart from this, the need for high-quality oligos is increasing due to the increase in R&D activities. Therefore, biotech and pharmaceutical companies' increasing research and development activities to treat various viral infections, chronic diseases, and genetic disorders are expected to fuel market growth over the forecast years.
For instance, in July 2017, Nitto Denko Avecia Inc. (Avecia) opened a new oligonucleotide API manufacturing facility in Milford, MA. The expansion has added 20,000 sq. ft. of manufacturing and office space at the site and provided CGMP oligonucleotide manufacturing capacity up to 1.8 mol, bringing the site capacity to 3.0 mol. Also, this expansion has helped Avecia's clients to receive timely oligonucleotide API to advance their drug development programs in clinical trials. However, the low-quality oligonucleotide sequences, lack of technical requirements, and the complexities associated with the oligonucleotide synthesis may hamper the market growth.
The Oligonucleotide Synthesis, Modification, and Purification Services Market is segmented into product, application, type, and end-users. By product, it includes primers, probes, and DNA oligos, such as molecular beacons, randomer oligos, and more specialized variants like unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) oligos, as well as other categories such as light-activated oligos and chimeric oligos. RNA oligos encompass single guide RNA (sgRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligos (ASO), sequencing primers, and aptamers. Applications include therapeutic uses for conditions like neurological disorders, rare diseases, and other medical conditions, alongside research applications in PCR, sequencing, and diagnostics. The market is further divided by types into customized oligos, predesigned oligos, reagents & consumables, and equipment. End-users span across hospitals, pharmaceutical and biotechnology companies, diagnostic laboratories, CROs and CMOs, and academic research institutes.
The market is being examined throughout North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa. Due to increased R&D investments in pharma and biotech businesses to enhance oligonucleotide production and synthesis processes, North America is likely to have the largest share of this market throughout the forecast years, followed by Europe.
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Report Attribute |
Specifications |
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Market Size Value In 2024 |
USD 4.69 Bn |
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Revenue Forecast In 2034 |
USD 12.27 Bn |
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Growth Rate CAGR |
CAGR of 10.02% from 2025 to 2034 |
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Quantitative Units |
Representation of revenue in US$ Billion and CAGR from 2025 to 2034 |
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Historic Year |
2021 to 2024 |
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Forecast Year |
2025-2034 |
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Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
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Segments Covered |
By Product, Application, Type, and End-User |
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Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
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Country Scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico ; France; Italy; Spain; South Korea; South East Asia |
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Competitive Landscape |
Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players |
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Customization Scope |
Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape. |
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Pricing And Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Snapshot
Chapter 4. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2024-2031
4.8. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Penetration & Growth Prospect Mapping (US$ Mn), 2023-2031
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2023)
4.10. Use/impact of AI on OLIGONUCLEOTIDE SYNTHESIS, MODIFICATION, AND PURIFICATION SERVICES MARKET Industry Trends
Chapter 5. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 1: By Product, Estimates & Trend Analysis
5.1. Market Share by Product, 2024 & 2034
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Product:
5.2.1. Primers
5.2.2. Probes
5.2.3. DNA Oligos
5.2.3.1. Molecular Beacons
5.2.3.2. Randomer Oligos
5.2.3.3. Unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) Oligos
5.2.3.4. Others (Light-activated Oligos, Chimeric Oligos and Trimers Mixes)
5.2.4. RNA Oligos
5.2.4.1. Single Guide RNA (sgRNA)
5.2.4.2. Small Interfering RNA (siRNA)
5.2.4.3. MicroRNA (miRNA)
5.2.4.4. Antisense Oligo (ASO)
5.2.4.5. Sequencing Primers
5.2.4.6. Aptamers
5.2.4.7. Others (Long RNA, etc.)
5.2.5. Others
Chapter 6. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 2: By Application, Estimates & Trend Analysis
6.1. Market Share by Application, 2024 & 2034
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:
6.2.1. Therapeutic Applications
6.2.1.1. Neurological Disorders
6.2.1.2. Rare Diseases
6.2.1.3. Other Diseases
6.2.2. Research Applications
6.2.2.1. PCR
6.2.2.2. Sequencing
6.2.2.3. Other Research Applications
6.2.3. Diagnostic Applications
Chapter 7. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 3: By Type, Estimates & Trend Analysis
7.1. Market Share by Type, 2024 & 2034
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Type:
7.2.1. Customized Oligos
7.2.2. Predesigned Oligos
7.2.3. Reagents & Consumables
7.2.4. Equipment
Chapter 8. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 4: By End User, Estimates & Trend Analysis
8.1. Market Share by End User, 2024 & 2034
8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End User:
8.2.1. Hospitals
8.2.2. Pharmaceutical & Biotechnology Companies
8.2.3. Diagnostic Laboratories
8.2.4. CROs and CMOs
8.2.5. Academic Research Institutes
Chapter 9. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 5: Regional Estimates & Trend Analysis
9.1. Global Oligonucleotide Synthesis, Modification, and Purification Services Market, Regional Snapshot 2024 & 2034
9.2. North America
9.2.1. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.2.1.1. US
9.2.1.2. Canada
9.2.2. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.2.3. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.2.4. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.2.5. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.3. Europe
9.3.1. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.3.1.1. Germany
9.3.1.2. U.K.
9.3.1.3. France
9.3.1.4. Italy
9.3.1.5. Spain
9.3.1.6. Rest of Europe
9.3.2. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.3.3. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.3.4. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.3.5. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.4. Asia Pacific
9.4.1. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.4.1.1. India
9.4.1.2. China
9.4.1.3. Japan
9.4.1.4. Australia
9.4.1.5. South Korea
9.4.1.6. Hong Kong
9.4.1.7. Southeast Asia
9.4.1.8. Rest of Asia Pacific
9.4.2. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.4.3. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.4.4. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts By Type, 2021-2034
9.4.5. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.5. Latin America
9.5.1. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.5.1.1. Brazil
9.5.1.2. Mexico
9.5.1.3. Rest of Latin America
9.5.2. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.5.3. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.5.4. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.5.5. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.6. Middle East & Africa
9.6.1. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
9.6.1.1. GCC Countries
9.6.1.2. Israel
9.6.1.3. South Africa
9.6.1.4. Rest of Middle East and Africa
9.6.2. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.6.3. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.6.4. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.6.5. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles
10.2.1. Agilent Technologies
10.2.1.1. Business Overview
10.2.1.2. Key Product/Service Type
10.2.1.3. Financial Performance
10.2.1.4. Geographical Presence
10.2.1.5. Recent Developments with Business Strategy
10.2.2. Ajinomoto Bio-Pharma Services
10.2.3. CordenPharma
10.2.4. Integrated DNA Technologies
10.2.5. Kaneka Eurogentec
10.2.6. LGC Biosearch Technologies
10.2.7. Microsynth
10.2.8. Merck KGaA
10.2.9. Nitto Avecia
10.2.10. Thermo Fisher Scientific
10.2.11. TriLink BioTechnologies
10.2.12. Creative Biolabs
10.2.13. Ella Biotech
10.2.14. Eurofins Scientific
10.2.15. Ribo Biotechnology
10.2.16. WuXi AppTec
10.2.17. GE Healthcare
10.2.18. Bio-synthesis Inc.
10.2.19. Almac Group
10.2.20. Sumitomo Chemical
10.2.21. BioSpring
10.2.22. ChemGenes
10.2.23. BianoScience GmbH
10.2.24. ATDBio Ltd
10.2.25. Burkert UK Limited
10.2.26. IBA Lifesciences GmbH
10.2.27. Other Market Players
Oligonucleotide Synthesis, Modification, and Purification Services Market- by Product
Oligonucleotide Synthesis, Modification, and Purification Services Market- Application
Oligonucleotide Synthesis, Modification, and Purification Services Market- Type
Oligonucleotide Synthesis, Modification, and Purification Services Market- End-users
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region,
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
To know more about the research methodology used for this study, kindly contact us/click here.
