In-vitro Transcription Templates Market Size, Share & Trends Analysis Report By Disease Type (Cancer (Solid Tumors, Colorectal Cancer, NSCLC, Melanoma, Leukemia, Prostate Cancer, Others), Infectious Disease (Influenza, COVID-19, AIDS, Others), Lifestyle Disease, Genetic Disease, Others), By Treatment (Vaccine, Therapeutic), By Research Stage (Exploratory, Clinical), By End-User (Pharmaceutical & Biotechnology Companies, CROs & CMOs, Academics & Research, Others), By Region, And By Segment Forecasts, 2024-2031

Report Id: 2397 Pages: 180 Last Updated: 19 March 2024 Format: PDF / PPT / Excel / Power BI
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In-vitro Transcription Templates Market Size is valued at USD 277.5 Mn in 2023 and is predicted to reach USD 1,134.1 Mn by the year 2031 at a 19.5% CAGR during the forecast period for 2024-2031.

In-vitro Transcription Templates Market info

In-vitro transcription templates are essential for a range of research and diagnostic purposes. These include creating mRNA for gene expression analysis, producing probes for RNA hybridization assays, and generating templates for in-vitro translation. In-vitro transcription templates are precise DNA sequences that act as templates for the production of RNA molecules through an in-vitro transcription process, which occurs outside of live cells. These templates include a promoter region that is recognized by RNA polymerase, which starts the process of transcribing the DNA sequence downstream into a complementary RNA strand. 

There is a high need for in-vitro transcription templates due to the growing interest in RNA-based research, which encompasses gene expression studies, transcriptomics, and RNA medications. Researchers are actively investigating the potential of RNA molecules in various applications, fueling the expansion of the market. Furthermore, the rise in genetic abnormalities and developments in gene-editing technologies drive the need for in-vitro transcription templates.

However, the market growth is hampered by the high-cost criteria for the safety and health of the in-vitro transcription templates market and the product's inability to prevent fog in environments with dramatic temperature fluctuations or high in-vitro transcription templates because the exorbitant expense of R&D, which includes the creation of in-vitro transcription templates, can impede the expansion of the market. The process's high price tag makes it out of budget for smaller research labs and universities. In addition, Experts in molecular biology methods are needed in the area of in-vitro transcription. However, the lack of properly educated workers threatens the market's expansion and adoption. The market for in-vitro transcription templates has been affected in different ways by the COVID-19 epidemic. Even though the pandemic immediately hampered research and laboratory operations, it ultimately brought attention to the need for RNA-based research and therapies.

Competitive Landscape

Some Major Key Players In The In-vitro Transcription Templates Market:

  • Thermo Fisher Scientific Inc.
  • Promega Corporation
  • Agilent Technologies, Inc.
  • New England Biolabs
  • Takara Bio Inc.
  • LGC Limited
  • Enzynomics Co. Ltd.
  • Enzo Life Sciences, Inc.
  • Danaher Corporation
  • Genscript Biotech Corporation
  • Eurofins Genomics LLC
  • TriLink Biotechnologies LLC
  • Bioline GMBH
  • Lucigen Corporation
  • Other Prominent Players

Market Segmentation:

The in-vitro transcription templates market is segmented based on disease type, treatment, and end-user. Based on disease type, the market comprises cancer, infectious disease, lifestyle disease, genetic disease, and others. By treatment, the market is segmented into vaccine, therapeutic. The research stage segment includes exploratory and clinical. By end-user, the market is segmented into pharmaceutical & biotechnology companies, CROs & CMOs, academics & research, and others.

Based On The Treatment, The Therapeutic Segment Is Accounted As A Major Contributor To The In-Vitro Transcription Templates Market.

The therapeutic in-vitro transcription templates market will hold a major global market share in 2022. The use of activity as a therapeutic tool is a function-based approach that considers the patient's current and future functional abilities through environment-specific activities and task-grading. A solid therapeutic connection allows the client to take an active role in their recovery, improving results. Although interest in gene therapy and RNA-based treatments continues to grow, there will be a greater need for therapeutic in-vitro transcription templates.

Pharmaceutical & Biotechnology Companies' Segment To Witness Growth At A Rapid Rate.

The pharmaceutical & biotechnology companies make up the bulk of acrylic acid ester usage because the pharmaceutical and healthcare organizations work on topics such as RNA engineering and modification, therapeutic applications, synthetic biology, high-throughput screening, improved transcription efficiency, and template design and engineering, especially in countries like the US, Germany, the UK, China, and India.

In The Region, The Asia Pacific In-Vitro Transcription Templates Market Holds A Significant Revenue Hare.

The Asia Pacific in-vitro transcription templates market is expected to register the maximum market revenue share in the near future. It can be attributed to substantial investments in molecular biology research, a robust research infrastructure, and the presence of important market participants. 

Recent Developments:

  • In Sept 2023, GenScript Biotech Corporation enhanced its IVT mRNA synthesis offerings by introducing personalized circular RNA (circRNA) and lipid nanoparticles (LNPs) formulation services. GenScript has promptly introduced new contract-manufactured reagent services as a demonstration of their dedication to offering state-of-the-art reagents that facilitate progress in areas such as vaccine development, protein replacement therapies, and gene and cell therapy. 
  • In September 2022, Thermo Fisher Scientific unveiled tailored Dynabeads technologies that facilitate the large-scale synthesis of mRNA. The Dynabeads™ Streptavidin for In Vitro Transcription & Dynabeads Carboxylic Acid for RNA Purification solutions facilitated the large-scale production and purification of mRNA for vaccine development and manufacturing at a Good Manufacturing Practice (GMP) level.  

In-Vitro Transcription Templates Market Report Scope

Report Attribute Specifications
Market Size Value In 2023 USD 277.5 Mn
Revenue Forecast In 2031 USD 1,134.1 Mn
Growth Rate CAGR CAGR of 19.5% from 2024 to 2031
Quantitative Units Representation of revenue in US$ Mn and CAGR from 2024 to 2031
Historic Year 2019 to 2023
Forecast Year 2024-2031
Report Coverage The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends
Segments Covered By Disease Type, Treatment, Research Stage And End-Use
Regional Scope North America; Europe; Asia Pacific; Latin America; Middle East & Africa
Country Scope U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; Southeast Asia; South Korea
Competitive Landscape Thermo Fisher Scientific Inc., Promega Corporation, Agilent Technologies, Inc., New England Biolabs, Takara Bio Inc., LGC Limited, Enzynomics Co. Ltd., Enzo Life Sciences, Inc., and Danaher Corporation, Genscript Biotech Corporation, Eurofins Genomics LLC, TriLink Biotechnologies LLC, Bioline GMBH, Lucigen Corporation
Customization Scope Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape.
Pricing And Available Payment Methods Explore pricing alternatives that are customized to your particular study requirements.

Segmentation of In-vitro Transcription Templates Market-

In-vitro Transcription Templates Market By Disease Type-

  • Cancer
    • Solid Tumors
    • Colorectal Cancer
    • NSCLC
    • Melanoma
    • Leukemia
    • Prostate Cancer
    • Others
  • Infectious Disease
    • Influenza
    • COVID-19
    • AIDS
    • Others
  • Lifestyle Disease
  • Genetic Disease
  • Others

In-vitro Transcription Templates Market seg

In-vitro Transcription Templates Market By Treatment

  • Vaccine
  • Therapeutic

In-vitro Transcription Templates Market By Research Stage

  • Exploratory
  • Clinical

In-vitro Transcription Templates Market By End-user

  • Pharmaceutical & Biotechnology Companies
  • CROs & CMOs
  • Academics & Research
  • Others

In-vitro Transcription Templates Market By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

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Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

In-vitro Transcription Templates Market Size is valued at USD 277.5 Mn in 2023 and is predicted to reach USD 1,134.1 Mn by the year 2031

In-vitro Transcription Templates Market is expected to grow at a 19.5% CAGR during the forecast period for 2024-2031.

Enzo Life Sciences, Inc., and Danaher Corporation, Genscript Biotech Corporation, Eurofins Genomics LLC, TriLink Biotechnologies LLC, Bioline GMBH, Lu
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