Global Molecular Glue Degrader Market Size is predicted to witness an 9.0% CAGR during the forecast period for 2025-2034.
Key Industry Insights & Findings from the Report:
Molecular glue degraders offer a novel approach to drug development, as they bring together a target protein and an E3 ligase, leading to the degradation of the target protein. As traditional treatment options for these diseases become less effective, there is a growing need for innovative therapies that can target the underlying causes of these diseases. Additionally, the increasing investment is leading to a rapid expansion of the molecular glue degrader market, with new players joining the field and existing companies expanding their portfolios. This, in turn, leads to the rising development of new and innovative molecular glue degraders and more efficient and cost-effective manufacturing processes.
Finally, the rise of biotech and pharmaceutical companies investing in this area is another key market driver. Furthermore, companies recognize this technology's potential and invest in research and development to bring new molecular glue degraders to market.
The molecular glue degrader market is segmented based on type, application and end users. The type segment includes PROteolysis Targeting Chimeras (PROTACs), Specific and Non-genetic IAP-dependent Protein ERasers (SNIPERs), Target ORiented ProtEin Degrader Optimizer (TORPEDO), Lysosomal Targeting Chimeras (LYTACs), and Others. By application, the market is segmented into cancer treatment, infectious diseases, genetic diseases, and others. By end users, the market is segmented into pharmaceutical and healthcare companies, Contract Research Organizations (CROs), and Contract Manufacturing Organizations (CMOs).
The cancer treatment category is expected to hold a major share in the global Molecular Glue Degrader market in 2024. Cancer treatment is one of the key applications of molecular glue degraders. Cancer is a complex and heterogeneous disease; many cancer cells rely on specific proteins for their growth and survival. Molecular glue degraders offer a novel approach to cancer treatment by targeting these particular proteins and inducing their degradation, which can lead to cancer cell death. One of the advantages of using molecular glue degraders for cancer treatment is their ability to target previously "undruggable" proteins. Many cancer cells rely on these proteins for their growth and survival, but traditional drug development approaches have been unable to target them effectively.
The PROTACs (PROteolysis TArgeting Chimeras) segment is projected to grow rapidly in the global Molecular Glue Degrader market. PROTACs (PROteolysis TArgeting Chimeras) are a class of small molecules that can induce the degradation of specific proteins by the ubiquitin-proteasome system. They are designed as bifunctional molecules that consist of three parts: a ligand that binds to the target protein, a ligand that binds to an E3 ubiquitin ligase, and a linker that connects the two ligands.
The North America Molecular Glue Degrader market is projected to register a tremendous market share in revenue soon. The US is known to be home to some of the world's largest biotech and pharmaceutical companies, which are investing heavily in developing new molecular glue degraders. The well-established research and development infrastructure in the United States provides a supportive environment for developing new drugs.
The favorable regulatory environment facilitates the approval and commercialization of new therapies. In addition, the Asia Pacific regional market is projected to grow rapidly in the global Molecular Glue Degrader market. Molecular glue degraders offer a promising approach to treating these diseases, and their potential to target previously "undruggable" proteins has generated significant interest in the markets in this region.
In May 2022, Evotec extended and expanded its partnership with Bristol Myers Squibb in targeted protein degradation. The collaboration has yielded a promising pipeline of molecular glue degraders, showcasing high productivity.
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Report Attribute |
Specifications |
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Growth rate CAGR |
CAGR of 9.0% from 2025 to 2034 |
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Quantitative units |
Representation of revenue in US$ Mn, and CAGR from 2025 to 2034 |
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Historic Year |
2021 to 2024 |
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Forecast Year |
2025-2034 |
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Report coverage |
The forecast of revenue, the position of the company, the competitive market statistics, growth prospects, and trends |
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Segments covered |
Type, Application And End Users |
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Regional scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
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Country scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; The UK; France; Italy; Spain; China; Japan; India; South Korea; Southeast Asia; South Korea; Southeast Asia |
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Competitive Landscape |
Proxygen GmbH, Tocris Bioscience, LifeSensors Inc., Evotec SE, Eli Lilly and Company, Bristol-Myers Squibb Company, C4 Therapeutics, Inc., Seed Therapeutics, Inc., Ranok Therapeutics Co. Ltd., Venquis Therapeutics |
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Customization scope |
Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape. |
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Pricing and available payment methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Molecular Glue Degrader Market Snapshot
Chapter 4. Global Molecular Glue Degrader Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis
Chapter 5. Market Segmentation 1: by Product Type Estimates & Trend Analysis
5.1. by Product Type & Market Share, 2024 & 2034
5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2021 to 2034 for the following by Product Type:
5.2.1. PROteolysis TArgeting Chimeras (PROTACs)
5.2.2. Specific and Non-genetic IAP-dependent Protein ERasers (SNIPERs)
5.2.3. Target ORiented ProtEin Degrader Optimizer (TORPEDO)
5.2.4. LYsosomal Targeting Chimeras ( LYTACs)
5.2.5. Others
Chapter 6. Market Segmentation 2: by Application Estimates & Trend Analysis
6.1. by Application & Market Share, 2024 & 2034
6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2021 to 2034 for the following by Application:
6.2.1. Cancer treatment
6.2.2. Infectious diseases
6.2.3. Genetic diseases
6.2.4. Others
Chapter 7. Market Segmentation 3: by End-use Estimates & Trend Analysis
7.1. by End-use & Market Share, 2024 & 2034
7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2021 to 2034 for the following by End-use:
7.2.1. Pharmaceutical and healthcare companies
7.2.2. Contract Research Organizations (CROs)
7.2.3. Contract Manufacturing Organizations (CMO)
Chapter 8. Molecular Glue Degrader Market Segmentation 4: Regional Estimates & Trend Analysis
8.1. North America
8.1.1. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
8.1.2. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
8.1.3. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2021-2034
8.1.4. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
8.2. Europe
8.2.1. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
8.2.2. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
8.2.3. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2021-2034
8.2.4. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
8.3. Asia Pacific
8.3.1. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
8.3.2. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
8.3.3. Asia-Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2021-2034
8.3.4. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
8.4. Latin America
8.4.1. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
8.4.2. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
8.4.3. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2021-2034
8.4.4. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
8.5. Middle East & Africa
8.5.1. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2021-2034
8.5.2. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
8.5.3. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2021-2034
8.5.4. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
Chapter 9. Competitive Landscape
9.1. Major Mergers and Acquisitions/Strategic Alliances
9.2. Company Profiles
9.2.1. Proxygene GmbH
9.2.2. Tories Bioscience,
9.2.3. Life Sensors Inc
9.2.4. Evotec SE
9.2.5. Eli Lilly and Company
9.2.6. Bristol-Myers Squibb Company
9.2.7. C4 Therapeutics, Inc.
9.2.8. Seed Therapeutics, Inc.
9.2.9. Rank Therapeutics Co. Ltd.
9.2.10. Vanquish Therapeutics
9.2.11. Other Prominent Players
Molecular Glue Degrader Market By Type-
Molecular Glue Degrader Market By Application-
Molecular Glue Degrader Market By End Users
Molecular Glue Degrader Market By Region-
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
To know more about the research methodology used for this study, kindly contact us/click here.
