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Molecular Glue Degrader Market

Molecular Glue Degrader Market Size, Share & Trends Analysis Report By Type (PROteolysis Targeting Chimeras (PROTACs), Specific and Non-genetic IAP-dependent Protein ERasers (SNIPERs), Target ORiented ProtEin Degrader Optimizer (TORPEDO), Lysosomal Targeting Chimeras (LYTACs)), Application (Cancer Treatment, Infectious Diseases, Genetic Diseases) And End Users, Region And Segment Forecasts, 2023-2031

Report ID : 1813 | Published : 2023-05-22 | Pages: 180 | Format: PDF/EXCEL

The Global Molecular Glue Degrader Market Size is predicted to witness an 8.71% CAGR during the forecast period for 2023-2031.

Molecular glue degraders offer a novel approach to drug development, as they bring together a target protein and an E3 ligase, leading to the degradation of the target protein. As traditional treatment options for these diseases become less effective, there is a growing need for innovative therapies that can target the underlying causes of these diseases. Additionally, the increasing investment is leading to a rapid expansion of the molecular glue degrader market, with new players joining the field and existing companies expanding their portfolios. This, in turn, leads to the rising development of new and innovative molecular glue degraders and more efficient and cost-effective manufacturing processes.

Molecular Glue Degrader Market

Finally, the rise of biotech and pharmaceutical companies investing in this area is another key market driver. Furthermore, companies recognize this technology's potential and invest in research and development to bring new molecular glue degraders to market.

 Recent Developments:

  • In January 2021, Arvin as Inc. joined a research partnership agreement with Pfizer Inc. to develop and commercialize novel protein degrader therapies.
  • In September 2020, Nuri Therapeutics, Inc. announced expanding its drug discovery collaboration with Gilead Sciences, Inc. to develop targeted protein degradation drugs for treating cancer and other diseases. 

Competitive Landscape:

Some of the Molecular Glue Degrader market players are:

  • Proxygene GmbH
  • Tories Bioscience,
  • Life Sensors Inc
  • Evotec SE
  • Eli Lilly and Company
  • Bristol-Myers Squibb Company
  • C4 Therapeutics, Inc.
  • Seed Therapeutics, Inc.
  • Rank Therapeutics Co. Ltd.
  • Vanquish Therapeutics 

Market Segmentation:

The molecular glue degrader market is segmented based on type, application and end users. The type segment includes PROteolysis Targeting Chimeras (PROTACs), Specific and Non-genetic IAP-dependent Protein ERasers (SNIPERs), Target ORiented ProtEin Degrader Optimizer (TORPEDO), Lysosomal Targeting Chimeras (LYTACs), and Others. By application, the market is segmented into cancer treatment, infectious diseases, genetic diseases, and others. By end users, the market is segmented into pharmaceutical and healthcare companies, Contract Research Organizations (CROs), and Contract Manufacturing Organizations (CMOs).

Based On Application, The Cancer Treatment Segment Is A Major Contributor To The Molecular Glue Degrader Market

The cancer treatment category is expected to hold a major share in the global Molecular Glue Degrader market in 2022. Cancer treatment is one of the key applications of molecular glue degraders. Cancer is a complex and heterogeneous disease; many cancer cells rely on specific proteins for their growth and survival. Molecular glue degraders offer a novel approach to cancer treatment by targeting these particular proteins and inducing their degradation, which can lead to cancer cell death. One of the advantages of using molecular glue degraders for cancer treatment is their ability to target previously "undruggable" proteins. Many cancer cells rely on these proteins for their growth and survival, but traditional drug development approaches have been unable to target them effectively.

PROTACs (PROteolysis TArgeting Chimeras) Segment Witnessed Growth At A Rapid Rate

The PROTACs (PROteolysis TArgeting Chimeras) segment is projected to grow rapidly in the global Molecular Glue Degrader market. PROTACs (PROteolysis TArgeting Chimeras) are a class of small molecules that can induce the degradation of specific proteins by the ubiquitin-proteasome system. They are designed as bifunctional molecules that consist of three parts: a ligand that binds to the target protein, a ligand that binds to an E3 ubiquitin ligase, and a linker that connects the two ligands.

The North American Molecular Glue Degrader Market Holds A Significant Regional Revenue Share

The North America Molecular Glue Degrader market is projected to register a tremendous market share in revenue soon. The US is known to be home to some of the world's largest biotech and pharmaceutical companies, which are investing heavily in developing new molecular glue degraders. The well-established research and development infrastructure in the United States provides a supportive environment for developing new drugs.

The favorable regulatory environment facilitates the approval and commercialization of new therapies. In addition, the Asia Pacific regional market is projected to grow rapidly in the global Molecular Glue Degrader market. Molecular glue degraders offer a promising approach to treating these diseases, and their potential to target previously "undruggable" proteins has generated significant interest in the markets in this region.

Molecular Glue Degrader Market Report Scope:

Report Attribute

Specifications

Growth rate CAGR

CAGR of 8.71 % from 2023 to 2031

Quantitative units

Representation of revenue in US$ Billion and CAGR from 2023 to 2031

Historic Year

2019 to 2022

Forecast Year

2023-2031

Report coverage

The forecast of revenue, the position of the company, the competitive market statistics, growth prospects, and trends

Segments covered

Type, Application And End Users

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; The UK; France; Italy; Spain; China; Japan; India; South Korea; Southeast Asia; South Korea; Southeast Asia

Competitive Landscape

Proxygen GmbH, Tocris Bioscience, LifeSensors Inc., Evotec SE, Eli Lilly and Company, Bristol-Myers Squibb Company, C4 Therapeutics, Inc., Seed Therapeutics, Inc., Ranok Therapeutics Co. Ltd., Venquis Therapeutics

Customization scope

Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape.

Pricing and available payment methods

Explore pricing alternatives that are customized to your particular study requirements.

Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Molecular Glue Degrader Market Snapshot

Chapter 4. Global Molecular Glue Degrader Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: by Product Type Estimates & Trend Analysis
5.1. by Product Type & Market Share, 2019 & 2031
5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Product Type:

5.2.1. PROteolysis TArgeting Chimeras (PROTACs)
5.2.2. Specific and Non-genetic IAP-dependent Protein ERasers (SNIPERs)
5.2.3. Target ORiented ProtEin Degrader Optimizer (TORPEDO)
5.2.4. LYsosomal Targeting Chimeras ( LYTACs)
5.2.5. Others

Chapter 6. Market Segmentation 2: by Application Estimates & Trend Analysis
6.1. by Application & Market Share, 2019 & 2031
6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by Application:

6.2.1. Cancer treatment
6.2.2. Infectious diseases
6.2.3. Genetic diseases
6.2.4. Others

Chapter 7. Market Segmentation 3: by End-use Estimates & Trend Analysis
7.1. by End-use & Market Share, 2019 & 2031
7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following by End-use:

7.2.1. Pharmaceutical and healthcare companies
7.2.2. Contract Research Organizations (CROs)
7.2.3. Contract Manufacturing Organizations (CMO)

Chapter 8. Molecular Glue Degrader Market Segmentation 4: Regional Estimates & Trend Analysis

8.1. North America

8.1.1. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2023-2031
8.1.2. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2023-2031
8.1.3. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2023-2031
8.1.4. North America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2023-2031

8.2. Europe

8.2.1. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2023-2031
8.2.2. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2023-2031
8.2.3. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2023-2031
8.2.4. Europe Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2023-2031

8.3. Asia Pacific

8.3.1. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2023-2031
8.3.2. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2023-2031
8.3.3. Asia-Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2023-2031
8.3.4. Asia Pacific Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2023-2031

8.4. Latin America

8.4.1. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2023-2031
8.4.2. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2023-2031
8.4.3. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2023-2031
8.4.4. Latin America Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2023-2031

8.5. Middle East & Africa

8.5.1. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2023-2031
8.5.2. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by Application, 2023-2031
8.5.3. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by End-use, 2023-2031
8.5.4. Middle East & Africa Molecular Glue Degrader Market Revenue (US$ Million) Estimates and Forecasts by country, 2023-2031

Chapter 9. Competitive Landscape

9.1. Major Mergers and Acquisitions/Strategic Alliances

9.2. Company Profiles


9.2.1. Proxygene GmbH
9.2.2. Tories Bioscience,
9.2.3. Life Sensors Inc
9.2.4. Evotec SE
9.2.5. Eli Lilly and Company
9.2.6. Bristol-Myers Squibb Company
9.2.7. C4 Therapeutics, Inc.
9.2.8. Seed Therapeutics, Inc.
9.2.9. Rank Therapeutics Co. Ltd.
9.2.10. Vanquish Therapeutics
9.2.11. Other Prominent Players

Segmentation of Molecular Glue Degrader Market-

Molecular Glue Degrader Market By Type-

  • Proteolysis Targeting Chimeras (Protags
  • Specific And Non-Genetic IAP-Dependent Protein Erasers (Snipers)
  • Target Oriented Protein Degrader Optimizer (TORPEDO)
  • Lysosomal Targeting Chimeras (Lyttas)
  • Others

Molecular Glue Degrader Market

Molecular Glue Degrader Market By Application-

  • Cancer Treatment
  • Infectious Diseases
  • Genetic Diseases
  • Others

Molecular Glue Degrader Market By End Users

  • Pharmaceutical And Healthcare Companies
  • Contract Research Organizations (CROs)
  • Contract Manufacturing Organizations (CMO)

Molecular Glue Degrader Market By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of Middle East and Africa

 InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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Frequently Asked Questions

How big is the Molecular Glue Degrader Market?

Molecular Glue Degrader Market expected to grow at 8.71% CAGR during the forecast period for 2023-2031.

Proxygen GmbH, Tocris Bioscience, LifeSensors Inc., Evotec SE, Eli Lilly and Company, Bristol-Myers Squibb Company, C4 Therapeutics, Inc., Seed Therap

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