Global Cell Free Protein Synthesis Market

Report ID : 1445 | Published : 2022-11-13 | Pages: | Format: PDF/EXCEL

The market size of the Global Cell Free Protein Synthesis Market in the year 2021 is valued at 239.91 million and is predicted to reach 412.32 million by the year 2030 at an 6.37% CAGR during the forecast period.

Cell-free protein is a valuable tool for molecular biologists in basic and applied sciences. Researchers in high-throughput functional proteomics and genomics increasingly use cell-free protein synthesis because it has considerable benefits over protein expression in living cells. The expanding R&D in proteomics and genomics, the increased prevalence of cancer and infectious disorders, and shorter-expression time and structural modification are all key drivers driving the growth of the cell-free protein synthesis market. Cell lysates are used in cell-free protein synthesis to produce the desired recombinant proteins. The lack of eukaryotic co- and post-translational modifications is one of the key roadblocks to the future expansion of the cell-free protein synthesis sector. Other key contributors include increased R&D outsourcing by biotechnological and pharmaceutical businesses, lower patent cliff revenues resulting in greater pharmaceutical sector research intensity, lower research productivity, and rising biosimilar development investment.

Furthermore, the recent increase in infectious disorders, such as lower respiratory infections and human immunodeficiency virus (HIV), due to climate change, changing land-use patterns, and fast urbanization are likely to boost market expansion. Furthermore, because of the brief reaction scales that result in the limited ability of resultant protein folding during protein expression, the addition of energy and substrate sources in the process can impact cell-free protein synthesis systems.

Market Segmentation:

The cell-free protein synthesis market is segmented on the product, application and end-use. Based on product, the market is divided into accessories, consumables, and lysate systems (E.coli Lysate, Wheat Germ Extract Lysate, Insect Cell Lysate, Human Cell Lysate, Rabbit Reticulocyte Lysate, and Other Lysate Systems). Based on application, the Cell-free protein synthesis market is segmented into enzyme engineering, protein labeling, protein-protein interaction, high throughput production and other application. Based on end-use, the cell-free protein synthesis market is segmented into pharmaceutical & biotechnology companies, academics & research institutes, and others.

Based on product, the lyscale systems segment is accounted as a major contributor to the cell-free protein synthesis market

Lyscale systems segment is expected to hold a significant market share during the forecast period. Lysates are free of endogenous genetic signals and have several advantages, including high protein production and tolerance to most additions. In addition, E. In recombinant approaches, coli-based systems are utilized to create a variety of biological medicines, including insulin. Continuous use has allowed for investigating the interactions and tolerability of E byproducts. coli-based methods. A substantial body of current scientific literature permits its quick adoption by industry and academia.

The pharmaceutical & biotechnology companies segment witnessed growth at a rapid rate.

The pharmaceutical & biotechnology companies grabbed the highest revenue share, and it is anticipated that they will continue to hold that position during the anticipated time. The increase in biopharmaceutical manufacturing capacities promotes the demand for cell free protein synthesis products. The construction of GMP facilities will meet the growing demand for contract development and manufacturing firms. It will also address the need for a greater range of raw materials and manufacturing methods. Regenerative medicines, RNA and DNA vaccines, cancer immunotherapy medications, and gene therapy will all be manufactured.

The North American cell-free protein synthesis market holds a significant revenue share in the region

The North American cell-free protein synthesis market is expected to register the highest market share in revenue soon. The United States has the largest market share in the North American region due to factors such as the increasing burden of cancer cases in the country, which is expected to stimulate demand for the cell-free protein synthesis market. The rising incidences of chronic diseases such as the aging population, and cancer, the growing need for targeted and customized medication, major R&D facilities, and favorable government initiatives in the United States. In addition, Asia Pacific is projected to grow rapidly in the global cell-free protein synthesis market. In Asia, cell-based research is gaining traction in academia and the biotechnology industry. The increased R&D investment in the region drives the market's significant expansion.

Competitive Landscape

The key players in the cell free protein synthesis market have shifted their focus toward product manufacturing and are initiating significant strategies such as mergers, acquisitions, and joint ventures of major and domestic players to enhance their product portfolio and strengthen their global market footprint. Some major key players in the Cell free protein synthesis market are Biotech rabbit, Genocopies, Inc., New England Biolabs, Merck Kagan, Promega Corporation., Jena Biosciences GmbH,Creative Biolabs., BioCentury Inc., Bioneer Corporation., Sutro Biopharma, Inc.

Chapter 1. Methodology and Scope

1.1. Research Methodology

1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Cell Free Protein Synthesis Market Snapshot

Chapter 4. Global Cell Free Protein Synthesis Market Variables, Trends & Scope

4.1. Market Segmentation & Scope

4.2. Drivers

4.3. Challenges

4.4. Trends

4.5. Investment and Funding Analysis

4.6. Industry Analysis – Porter’s Five Forces Analysis

4.7. Competitive Landscape & Market Share Analysis

4.8. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: by Product Type Estimates & Trend Analysis

5.1. by Product Type & Market Share, 2019 & 2030

5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2030 for the following by Product Type:

5.2.1. Accessories and Consumables

5.2.2. Lyscale Systems

5.2.2.1. E.coli Lysate

5.2.2.2. Wheat Germ Extract Lysate

5.2.2.3. Insect Cell Lysate

5.2.2.4. Human Cell Lysate

5.2.2.5. Rabbit Reticulocyte Lysate

5.2.2.6. Other Lysate Systems

Chapter 6. Market Segmentation 2: by Application Estimates & Trend Analysis

6.1. by Application & Market Share, 2019 & 2030

6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2030 for the following by Application:

6.2.1. Enzyme Engineering

6.2.2. Protein Labeling

6.2.3. Protein-Protein Interaction

6.2.4. High Throughput Production

6.2.5. Other End use

Chapter 7. Market Segmentation 3: by End use Estimates & Trend Analysis

7.1. by End use & Market Share, 2019 & 2030

7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2030 for the following by End use:

7.2.1. Pharmaceutical & Biotechnology Companies

7.2.2. Academics & Research Institutes

7.2.3. Others

Chapter 8. Cell Free Protein Synthesis Market Segmentation 4: Regional Estimates & Trend Analysis

8.1. North America

8.1.1. North America Cell Free Protein Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Product Type, 2022-2030

8.1.2. North America Cell Free Protein Synthesis Market Revenue (US$ Million) Estimates and Forecasts by Application, 2022-2030

8.1.3. North America Cell Free Protein Synthesis Market revenue (US$ Million) by End use, 2022-2030

8.1.4. North America Cell Free Protein Synthesis Market Revenue (US$ Million) Estimates and Forecasts by country, 2022-2030

8.2. Europe

8.2.1. Europe Cell Free Protein Synthesis Market revenue (US$ Million) by Product Type, 2022-2030

8.2.2. Europe Cell Free Protein Synthesis Market revenue (US$ Million) by Application, 2022-2030

8.2.3. Europe Cell Free Protein Synthesis Market revenue (US$ Million) by End use, 2022-2030

8.2.4. Europe Cell Free Protein Synthesis Market revenue (US$ Million) by country, 2022-2030

8.3. Asia Pacific

8.3.1. Asia Pacific Cell Free Protein Synthesis Market revenue (US$ Million) by Product Type, 2022-2030

8.3.2. Asia Pacific Cell Free Protein Synthesis Market revenue (US$ Million) by Application, 2022-2030

8.3.3. Asia-Pacific Cell Free Protein Synthesis Market revenue (US$ Million) by End use, 2022-2030

8.3.4. Asia Pacific Cell Free Protein Synthesis Market revenue (US$ Million) by country, 2022-2030

8.4. Latin America

8.4.1. Latin America Cell Free Protein Synthesis Market revenue (US$ Million) by Product Type, 2022-2030

8.4.2. Latin America Cell Free Protein Synthesis Market revenue (US$ Million) by Application, 2022-2030

8.4.3. Latin America Cell Free Protein Synthesis Market revenue (US$ Million) by End use, 2022-2030

8.4.4. Latin America Cell Free Protein Synthesis Market revenue (US$ Million) by country, 2022-2030

8.5. Middle East & Africa

8.5.1. Middle East & Africa Cell Free Protein Synthesis Market revenue (US$ Million) by Product Type, 2022-2030

8.5.2. Middle East & Africa Cell Free Protein Synthesis Market revenue (US$ Million) by Application, 2022-2030

8.5.3. Middle East & Africa Cell Free Protein Synthesis Market revenue (US$ Million) by End use, 2022-2030

8.5.4. Middle East & Africa Cell Free Protein Synthesis Market revenue (US$ Million) by country, 2022-2030

Chapter 9. Competitive Landscape

9.1. Major Mergers and Acquisitions/Strategic Alliances

9.2. Company Profiles

9.2.1. Biotechrabbit

9.2.2. GeneCopoeia, Inc.

9.2.3. New England Biolabs

9.2.4. Merck KGaA

9.2.5. Promega Corporation.

9.2.6. Jena Biosciences GmbH

9.2.7. Creative Biolabs.

9.2.8. BioCentury Inc.

9.2.9. Bioneer Corporation.

9.2.10. Sutro Biopharma, Inc

9.2.11. Other Prominent Players

By Product

  • Accessoires and Consumables
  • Lyscale Systems
    • coli Lysate
    • Wheat Germ Extract Lysate
    • Insect Cell Lysate
    • Human Cell Lysate
    • Rabbit Reticulocyte Lysate
    • Other Lysate Systems

By Application

  • Enzyme Engineering
  • Protein Labeling
  • Protein-Protein Interaction
  • High Throughput Production
  • Other Application

By End Use

  • Pharmaceutical & Biotechnology Companies
  • Academics & Research Institutes
  • Others

By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of Middle East and Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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