Allogeneic Stem Cell Transplantation Market Size, Share & Trends Analysis Report By Source (Bone Marrow, Peripheral Blood, Umbilical Cord Blood, Adipose Tissue, Dental Pulp, and Others), By Application (Cancer, Autoimmune Diseases, Blood Disorders, Cardiac Disorders, Neurological Disorders, Diabetes, and Others), By End User (Hospitals, Research Institutes, Specialty Clinics, and Others), By Cell Type, By Region, And By Segment Forecasts, 2023-2031.

Report Id: 2241 Pages: 179 Last Updated: 11 February 2025 Format: PDF / PPT / Excel / Power BI
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Allogeneic Stem Cell Transplantation Market Size is valued at USD 3.66 Bn in 2022 and is predicted to reach USD 6.75 Bn by the year 2031 at a 7.21% CAGR during the forecast period for 2023-2031.

Key Industry Insights & Findings from the Report:

  • The market is propelled by increased incidence of chronic illnesses such cancer, autoimmune diseases, and blood disorders. Over the past ten years, there has been a consistent rise in the number of new instances of illnesses like leukemia, multiple myeloma, and lymphoma.
  • The field of allogeneic stem cell-based therapies has expanded with the advancements in stem cell expansion, harvesting, and therapeutic application. 
  • Blood malignancies have also responded well to medication combinations and cell treatment. Allogeneic stem cell therapies are anticipated to yield greater benefits through the adoption of combination techniques.
  • North America dominated the market and accounted for a global revenue share in 2023.
  • Complex requirements for handling and transportation raise the cost of logistics as well. Affordability is severely impacted by inadequate reimbursement and sparse insurance coverage in some areas. The market's expansion is limited mostly by the subsequent high costs associated with treatment.

Allogeneic Stem Cell Transplantation Market

Allogeneic stem cell transplantation, also known as allogeneic hematopoietic stem cell transplantation (HSCT), refers to transferring the significant stem cells from a healthy donor to a desired patient. The donor can either be a biological relative, typically a sibling, or an unrelated individual whose tissue type is compatible with the recipient's. HLA matching can prevent graft rejection, graft-versus-host disease (GvHD), and other complications. Stem cells are exist in both the bone marrow and the blood. Hematopoietic stem cells are nascent or undeveloped blood cells within the bone marrow. Blood cells undergo maturation in the bone marrow, but only a minuscule portion of them enter the bloodstream. The cells that enter the bloodstream are referred to as peripheral blood stem cells. Moreover, the integration of allogeneic stem cells with biomaterials to generate bioengineered tissues and organs presents innovative possibilities for addressing severe diseases and injuries. The following are the latest trends in the allogeneic stem cell industry that are driving its growth. 

In Addition, the market growth is impaded by the strict regulatory criteria for the safety and health of allogeneic stem cell transplantation and the product's inability to prevent fog in environments with dramatic temperature fluctuations or high humidity allogeneic stem cell transplantation, although regulatory rules are changing to facilitate the commercialization of cell therapies, rigorous evaluation is still required because of the lack of clarity regarding their long-term safety and effectiveness. Manufacturers must adhere to stringent restrictions from procuring stem cells via good tissue practices, cGMP standards, quality checks, and required preclinical research. To halt the spread of COVID-19, many nations have instituted nationwide lockdowns. Companies in the healthcare industry across the globe faced similar challenges when trying to keep their supply chains running smoothly. Since the frequency of new instances of COVID-19 decreased, limitations on patients visiting hospitals to receive treatment were relaxed.

Competitive Landscape

Some Major Key Players In The Allogeneic Stem Cell Transplantation Market:

  • Celgene Corporation
  • Mesoblast Ltd.
  • Pluristem Therapeutics Inc.
  • MEDIPOST Co., Ltd.
  • Takeda Pharmaceutical Company Limited
  • Astellas Pharma Inc.
  • Cellular Biomedicine Group, Inc.
  • Biosolution Co., Ltd.
  • StemCell Technologies Inc.
  • Caladrius Biosciences, Inc.
  • TiGenix N.V.
  • ViaCord
  • Vericel Corporation
  • Regen Biopharma Inc.
  • Gamida Cell Ltd.
  • Histogenics Corporation
  • BrainStorm Cell Therapeutics Inc.
  • Lineage Cell Therapeutics, Inc.
  • Bluebird Bio
  • Sanofi
  • Talaris Therapeutics.
  • Others

Market Segmentation:

The allogeneic stem cell transplantation market is segmented based on source, application, end user and cell type. According to source segment, the market is segmented into bone marrow, peripheral blood, umbilical cord blood, adipose tissue, dental pulp, and others. The application segment is segmented into cancer, autoimmune diseases, blood disorders, cardiac disorders, neurological disorders, diabetes, and others. By end user, the market is segmented into hospitals, research institutes, speciality clinics, and others. By cell type, the market is segmented into allogeneic MSCs, allogeneic HSCs, and others.

Based On The Source, The Bone Marrow Segment Is A Major Contributor To The Allogeneic Stem Cell Transplantation Market. 

The bone marrow allogeneic stem cell transplantation market is expected to lead with a major global market share in 2022. Bone marrow stem cell transplantation has shown promise as a potential cure for some haematological diseases, especially when standard treatments have failed or the disease has returned. For individuals who are candidates, this treatment is crucial since it can prolong life for years without relapse.

The Hospital Segment Is Witnessing Growth At A Rapid Rate.

The hospital industry makes up the bulk of allogeneic stem cell transplantation because, in modern hospitals, patients have access to state-of-the-art medical technology, including bone marrow transplantation units. These resources allow hospitals to provide comprehensive pre-and post-transplant care for HSCT recipients, especially in countries like the US, Germany, the UK, China, and India.

In The Region, The North American Allogeneic Stem Cell Transplantation Market Holds A Significant Revenue Share.

The North American allogeneic stem cell transplantation market is expected to record the maximum market share in revenue in the near future. It can be attributed to the high acceptance of stem cell therapies, improved healthcare infrastructure, and increasing R&D investments fueling the market's expansion. In addition, Asia Pacific is estimated to grow rapidly in the global allogeneic stem cell transplantation market because of the large population and increasing demand for high-quality healthcare in the region, as well as the growing number of people who are becoming more health-conscious and in need of cutting-edge medical technology for skin care.

Recent Developments:

  • In September 2023, Mesoblast collaborated with the Blood & Marrow Transplant Clinical Trials Network (BMT CTN) to conduct a clinical trial examining the effectiveness of its drug, Ryoncil (remestemcel-L), in treating steroid-refractory acute graft versus host disease (SR-aGvHD).  BMT CTN will undertake the trial to assess the efficacy of Ryoncil in patients aged 12 and above who have shown inadequate response to prior treatments such as corticosteroids and a second-line drug like ruxolitinib.  

Allogeneic Stem Cell Transplantation Market Report Scope

Report Attribute Specifications
Market Size Value In 2022 USD 3.66 Bn
Revenue Forecast In 2031 USD 6.75 Bn
Growth Rate CAGR CAGR of 7.21% from 2023 to 2031
Quantitative Units Representation of revenue in US$ Bn and CAGR from 2023 to 2031
Historic Year 2019 to 2022
Forecast Year 2023-2031
Report Coverage The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends
Segments Covered By Source, Application, Cell Type, End-User
Regional Scope North America; Europe; Asia Pacific; Latin America; Middle East & Africa
Country Scope U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South East Asia; South Korea
Competitive Landscape Celgene Corporation, Mesoblast Ltd., Pluristem Therapeutics Inc., MEDIPOST Co., Ltd., Takeda Pharmaceutical Company Limited, Astellas Pharma Inc., Cellular Biomedicine Group, Inc., Biosolution Co., Ltd., StemCell Technologies Inc., Caladrius Biosciences, Inc., TiGenix N.V., ViaCord, Vericel Corporation, Regen Biopharma Inc., Gamida Cell Ltd., Histogenics Corporation, BrainStorm Cell Therapeutics Inc., Lineage Cell Therapeutics, Inc., Bluebird Bio, Sanofi, Talaris Therapeutics and Others
Customization Scope Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape.
Pricing And Available Payment Methods Explore pricing alternatives that are customized to your particular study requirements.

Segmentation of Allogeneic Stem Cell Transplantation Market-

Allogeneic Stem Cell Transplantation Market By Source

  • Bone Marrow
  • Peripheral Blood
  • Umbilical Cord Blood
  • Adipose Tissue
  • Dental Pulp
  • Others

Allogeneic Stem Cell Transplantation Market Seg

Allogeneic Stem Cell Transplantation Market By Cell Type

  • Allogeneic MSCs (Allogenic Mesenchymal stem cells)
  • Allogeneic HSCs (Allogeneic hematopoietic stem cells)
  • Others

Allogeneic Stem Cell Transplantation Market By Application

  • Cancer
  • Autoimmune Diseases
  • Blood Disorders
  • Cardiac Disorders
  • Neurological Disorders
  • Diabetes
  • Others

Allogeneic Stem Cell Transplantation Market By End User

  • Hospitals
  • Research Institutes
  • Specialty Clinics
  • Others

Allogeneic Stem Cell Transplantation Market By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

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Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

Allogeneic Stem Cell Transplantation Market Size is valued at USD 3.66 Bn in 2022 and is predicted to reach USD 6.75 Bn by the year 2031

Allogeneic Stem Cell Transplantation Market expected to grow at a 7.21% CAGR during the forecast period for 2023-2031.

Gamida Cell Ltd., Histogenics Corporation, BrainStorm Cell Therapeutics Inc., Lineage Cell Therapeutics, Inc., Bluebird Bio, Sanofi, Talaris Therapeut
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