Non-covid mRNA Vaccine and Therapeutics Market Size is valued at USD 370 Mn in 2024 and is predicted to reach USD 1,684.80 Mn by the year 2031 at an 24.20% CAGR during the forecast period for 2024-2031.
Non-covid-19 mRNA therapeutics involve using synthetic mRNA to instruct cells to produce specific proteins for treating or preventing diseases. This approach allows for precise targeting by encoding therapeutic proteins or antigens, helping treat conditions like cancer, genetic disorders, and infectious diseases. For instance, mRNA can be designed to stimulate the immune system against cancer cells or replace missing proteins in genetic disorders. Unlike traditional vaccines that use weakened pathogens, mRNA vaccines deliver genetic instructions to prompt the body to produce a harmless piece of a pathogen, triggering an immune response.
The applications of non-covid mRNA vaccine and therapeutics are expanding into cancer treatment, genetic disorders, and infectious diseases like influenza and Zika virus. Additionally, mRNA technology is being explored to modulate immune responses in autoimmune diseases. A key factor driving growth in this area is advancements in delivery technologies like lipid nanoparticles (LNPs), which improve the stability and precision of mRNA therapeutics. These innovations make mRNA a promising option for chronic disease treatment by enhancing targeting and reducing immunogenicity issues.
The non-covid mRNA vaccine and therapeutics market is segmented by product type, therapeutic area, route of administration. By product type the market is segmented into mRNA therapeutic, mRNA vaccines. By therapeutic area market is categorized into infectious diseases, oncological disorders, other disorders. Infectious disease sub segmented into influenza, respiratory syncytial virus (RSV), cytomegalovirus, and others. By route of administration the market is categorized into intravenous, intramuscular, intranasal, and others.
The predominant driver of the non-covid mRNA vaccine and therapeutics market is the mRNA vaccines segment with many major reasons attached to it. It has broad applicability to vaccines targeting various cancers and infectious diseases like influenza, Zika, and rabies, hence giving it versatility and adaptability to emerging health threats. The mRNA vaccine improves efficacy and safety and takes it into cells with greater ease for both prevention and therapy, improved by technological advances in this case of delivery systems through lipid nanoparticles. Another important attribute of mRNA technology is that it allows for more rapid development and scalability, thereby making a tool that can be rapidly applied to an outbreak, placing this technology at the forefront of vaccine development
The infectious diseases segment in the non-covid mRNA vaccine and therapeutics market has been growing significantly because of a few key factors. The agility of the technology in adapting to a variety of pathogens has led to the development of mRNA vaccines for a vast number of diseases, such as influenza, HIV, Zika virus, and RSV. Advances in mRNA-based clinical trials, with several candidates at the phase II and III stage, have given added momentum and increased investment into the applications of mRNA.
The strongest area that leads the market in North America for non-covid mRNA vaccine and therapeutics would be because of a well-developed research and development infrastructure, significant funding, and a friendly regulatory environment. Additionally, the U.S. is host to one of the most robust R&D ecosystems, with many pharmaceutical companies, biotech firms, and academic institutions that drive innovation in the field of mRNA technology. Massive funding from the public and private sectors supports a diversified pipeline, such as those for infectious diseases and cancer therapies. Moreover, the U.S. FDA's fast-tracked review program further accelerates the approval and subsequent commercialization of new therapeutics, adding more momentum to the market's growth in the region.
| Report Attribute | Specifications |
| Market Size Value In 2024 | USD 370.0 Mn |
| Revenue Forecast In 2031 | USD 1,684.80 Mn |
| Growth Rate CAGR | CAGR of 24.20% from 2024 to 2031 |
| Quantitative Units | Representation of revenue in US$ Mn and CAGR from 2024 to 2031 |
| Historic Year | 2019 to 2023 |
| Forecast Year | 2024-2031 |
| Report Coverage | The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
| Segments Covered | By Product Type, Therapeutic Area, Route of Administration and By Region |
| Regional Scope | North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
| Country Scope | U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South Korea; Southeast Asia |
| Competitive Landscape | CureVac, Anima Biotech, Arcturus Therapeutics, BioNTech (Pfizer), eFFECTOR Therapeutics, Inc., eTheRNA, Ethris (AstraZeneca), H3 Biomedicine Inc. (Eisai Inc.), In-Cell-Art, Ionis Pharmaceuticals, Inc., Kernal Biologics, Moderna, RNAimmune (Sirnaomics), Silence Therapeutics, Skyhawk Therapeutics, Inc., Stemirna Therapeutics Co., Ltd., Tiba Biotechnology, Translate Bio Sanofi), Ziphius Therapeutics NV |
| Customization Scope | Free customization report with the procurement of the report, Modifications to the regional and segment scope. Geographic competitive landscape. |
| Pricing and Available Payment Methods | Explore pricing alternatives that are customized to your particular study requirements. |
Non-covid mRNA Vaccine and Therapeutics Market by Product Type
Non-covid mRNA Vaccine and Therapeutics Market by Therapeutic area
Non-covid mRNA Vaccine and Therapeutics Market by Route of Administration
Non-covid mRNA Vaccine and Therapeutics Market by Region
North America-
Europe-
Asia-Pacific-
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Middle East & Africa-
This study employed a multi-step, mixed-method research approach that integrates:
This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.
Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.
Secondary data for the market study was gathered from multiple credible sources, including:
These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.
Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.
Primary interviews for this study involved:
Interviews were conducted via:
Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.
All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.
The data validation process included:
This ensured that the dataset used for modelling was clean, robust, and reliable.
The bottom-up approach involved aggregating segment-level data, such as:
This method was primarily used when detailed micro-level market data were available.
The top-down approach used macro-level indicators:
This approach was used for segments where granular data were limited or inconsistent.
To ensure accuracy, a triangulated hybrid model was used. This included:
This multi-angle validation yielded the final market size.
Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.
Given inherent uncertainties, three scenarios were constructed:
Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.