The Neostigmine Methylsulfate Injection Market Size is valued at USD 156.54 Mn in 2022 and is predicted to reach USD 228.43 Mn by the year 2031 at a 4.4% CAGR during the forecast period for 2023-2031.
Neostigmine methylsulfate is a reversible cholinesterase inhibitor. Cholinesterases are enzymes responsible for breaking down the neurotransmitter acetylcholine at the neuromuscular junction. By inhibiting these enzymes, neostigmine allows acetylcholine to accumulate, leading to increased stimulation of skeletal muscle. A unique stability-indicating reverse phase HPLC method was created and validated for the quantitative determination of associated impurities and degradation impurities in neostigmine methylsulfate API and injectable formulation.
A popular quaternary ammonium chemical called methyl sulphate is utilized as a competitive cholinesterase inhibitor. It raises the levels of acetylcholine by reducing its breakdown in the synaptic cleft. As a non-depolarizing neuromuscular blocking drug, this acetylcholine competes for the binding sites and breaks the neuromuscular blockade. The nicotinic and muscarinic actions are amplified as a result. It makes the skeletal muscles active.
Since neostigmine methylsulfate cannot easily cross the blood-brain barrier, the central nervous system is unaffected. Neostigmine methylsulfate does not absorb well into the digestive system because of its ionic composition. As a result, it is given as a parenteral injection.
The neostigmine methylsulfate injection market is segmented on the basis of application, distribution channel, and end user. As per application, the market is segmented as myasthenia gravis and reversal of neuromuscular blockade. Acording to distribution channel, the market is divided into hospital, retail pharmacies, and online pharmacies. On the basis of end-users, the market is divided into hospitals, speciality clinics, and ambulatory surgical centres.
The myasthenia gravis category is expected to hold a major share of the global neostigmine methylsulfate injection market in 2022. By increasing muscle tone, the cholinesterase inhibitor neostigmine is used to treat the indications of myasthenia gravis. Physostigmine crosses the blood-brain barrier; neostigmine does not. Since there are fewer receptors present in myasthenia gravis, blocking acetylcholinesterase increases the amount of acetylcholine that is available in the synapse and improves its ability to bind to those receptors and cause muscle contraction.
The hospital pharmacy is estimated to grow at a rapid rate in the global neostigmine methylsulfate injection market. Increasing hospitalization for treatment of the patients with myasthenia gravis and reversal of neuromuscular blockade. Furthermore, the elderly are more prone to neurological conditions like myasthenia gravis, which frequently need to be treated in hospitals with injections of neostigmine methylsulfate. The need for drugs that treat age-related illnesses, such as neostigmine methylsulfate injections, is rising as the world's elderly population keeps expanding.
The North American neostigmine methylsulfate injection market is expected to record the maximum market share in terms of revenue in the near future. Increasing research and development in the region is anticipated to drive the market developments in the coming years. Moreover, rising FDA approvals for various competitors are expected to boost the market growth. A cholinesterase inhibitor called neostigmine methylsulfate injection is recommended for reversing the effects of non-depolarizing neuromuscular blocking drugs (NMBA) after surgery.
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Report Attribute |
Specifications |
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Market size value in 2022 |
USD 156.54 Mn |
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Revenue forecast in 2031 |
USD 228.43 Mn |
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Growth rate CAGR |
CAGR of 4.4% from 2023 to 2031 |
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Quantitative units |
Representation of revenue in US$ Million and CAGR from 2023 to 2031 |
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Historic Year |
2019 to 2022 |
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Forecast Year |
2023-2031 |
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Report coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
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Segments covered |
By Application, Distribution Channel, End-User |
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Regional scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
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Country scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico ;The UK; France; Italy; Spain; China; Japan; India; South Korea; South East Asia; South Korea; South East Asia |
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Competitive Landscape |
Pfizer Inc., Fresenius Kabi AG, Mylan N.V., Sandoz Inc., Bausch Health Companies Inc., Sun Pharmaceutical Industries Ltd., Hospira (now part of Pfizer), Akorn Pharmaceuticals, and Baxter International Inc. |
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Customization scope |
Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape. |
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Pricing and available payment methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Neostigmine Methylsulfate Injection Market Snapshot
Chapter 4. Global Neostigmine Methylsulfate Injection Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis
Chapter 5. Market Segmentation 1: By Distribution Channel Estimates & Trend Analysis
5.1. By Distribution Channel, & Market Share, 2020 & 2031
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Distribution Channel:
5.2.1. Hospital Pharmacies
5.2.2. Retail Pharmacies
5.2.3. Online Pharmacies
Chapter 6. Market Segmentation 2: By Application Estimates & Trend Analysis
6.1. By Application & Market Share, 2020 & 2031
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Application:
6.2.1. Myasthenia Gravis
6.2.2. Reversal of Neuromuscular Blockade
Chapter 7. Market Segmentation 3: By End-use Estimates & Trend Analysis
7.1. By End-use & Market Share, 2020 & 2031
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By End-use:
7.2.1. Hospitals
7.2.2. Specialty Clinics
7.2.3. Ambulatory Surgical Centers
Chapter 8. Neostigmine Methylsulfate Injection Market Segmentation 4: Regional Estimates & Trend Analysis
8.1. North America
8.1.1. North America Neostigmine Methylsulfate Injection Market revenue (US$ Million) estimates and forecasts By Distribution Channel, 2019-2031
8.1.2. North America Neostigmine Methylsulfate Injection Market revenue (US$ Million) estimates and forecasts By Application, 2019-2031
8.1.3. North America Neostigmine Methylsulfate Injection Market revenue (US$ Million) estimates and forecasts By End-use, 2019-2031
8.1.4. North America Neostigmine Methylsulfate Injection Market revenue (US$ Million) estimates and forecasts by country, 2019-2031
8.2. Europe
8.2.1. Europe Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Distribution Channel, 2019-2031
8.2.2. Europe Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Application, 2019-2031
8.2.3. Europe Neostigmine Methylsulfate Injection Market revenue (US$ Million) By End-use, 2019-2031
8.2.4. Europe Neostigmine Methylsulfate Injection Market revenue (US$ Million) by country, 2019-2031
8.3. Asia Pacific
8.3.1. Asia Pacific Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Distribution Channel, 2019-2031
8.3.2. Asia Pacific Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Application, 2019-2031
8.3.3. Asia Pacific Neostigmine Methylsulfate Injection Market revenue (US$ Million) By End-use, 2019-2031
8.3.4. Asia Pacific Neostigmine Methylsulfate Injection Market revenue (US$ Million) by country, 2019-2031
8.4. Latin America
8.4.1. Latin America Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Distribution Channel, (US$ Million) 2019-2031
8.4.2. Latin America Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Application, (US$ Million) 2019-2031
8.4.3. Latin America Neostigmine Methylsulfate Injection Market revenue (US$ Million) By End-use, (US$ Million) 2019-2031
8.4.4. Latin America Neostigmine Methylsulfate Injection Market revenue (US$ Million) by country, 2019-2031
8.5. Middle East & Africa
8.5.1. Middle East & Africa Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Distribution Channel, (US$ Million) 2019-2031
8.5.2. Middle East & Africa Neostigmine Methylsulfate Injection Market revenue (US$ Million) By Application, (US$ Million) 2019-2031
8.5.3. Middle East & Africa Neostigmine Methylsulfate Injection Market revenue (US$ Million) By End-use, (US$ Million) 2019-2031
8.5.4. Middle East & Africa Neostigmine Methylsulfate Injection Market revenue (US$ Million) by country, 2019-2031
Chapter 9. Competitive Landscape
9.1. Major Mergers and Acquisitions/Strategic Alliances
9.2. Company Profiles
9.2.1. Pfizer Inc.
9.2.2. Fresenius Kabi AG
9.2.3. Mylan N.V.
9.2.4. Sandoz Inc
9.2.5. Bausch Health Companies Inc
9.2.6. Sun Pharmaceutical Industries Ltd
9.2.7. Hospira (now part of Pfizer)
9.2.8. Akorn Pharmaceuticals
9.2.9. Baxter International Inc.
9.2.10. Hikma Pharmaceuticals
9.2.11. Endo International
Neostigmine Methylsulfate Injection Market By Application
Neostigmine Methylsulfate Injection Market By Distribution Channel
Neostigmine Methylsulfate Injection Market By End User
Neostigmine Methylsulfate Injection Market By Region-
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.
To know more about the research methodology used for this study, kindly contact us/click here.4456
