Global Single-use Upstream Bioprocessing Market

Report ID : 1318 | Published : 2022-07-13 | Pages: | Format: PDF/EXCEL

The Global Single-use Upstream Bioprocessing Market is estimated to reach over USD 34.54 billion by 2030, exhibiting a CAGR of 16.6% during the forecast period.

The first step in the bioprocess is upstream bioprocessing, which is used to generate cell lines and cultivate them in order to grow the cells by harvesting. Modern cell growth techniques produce bioreactors with noticeably higher titers, shorter time constraints, and more precision. Upstream manufacturing's main objective is to create the environment necessary for cells to manufacture the desired protein. Biomanufacturing is used to develop therapeutic proteins, antibiotics, hormones, enzymes, amino acids, blood substitutes, and alcohol for medical use. Businesses have been forced to adopt cutting-edge technologies like single-use bioprocessing techniques because they are affordable and hasten the production process. This is because there aren't many potential new medicines in the pipeline, blockbuster molecules' patents are about to expire, and there's an increased demand for biologics. Better cell culture medium, more advanced feeding strategies, more resilient cell lines, and bioreactor control suited for specific needs are the main upstream development pillars that have led to the field's overall advancement. The growing demand for biopharmaceuticals and the significant role that single-use bioprocessing systems play in reducing the investment costs and R&D expenses associated with the biologics manufacturing process are two factors driving the market's expansion.

List of Prominent Players in the Single-use Upstream Bioprocessing Market:

Danaher Corporation (Cytiva),

Sartorius AG,

Thermo Fisher Scientific, Inc.,

Merck KGaA,

Corning Incorporated,

Pall Corporation,

General Electric Company (GE Healthcare),

Eppendorf AG,

Rentschler Biopharma SE,

Lonza,

Meissner Filtration Products, Inc.,

JM BioConnect,

Boehringer Ingelheim GmbH,

Infors A

Market Dynamics:

Drivers-

The demand for biopharmaceuticals is anticipated to rise as the senior population grows across key markets since the aged are more susceptible to chronic illnesses & conditions. Companies increasingly favour single-use bioprocessing systems to meet the rising demand for biopharmaceuticals because they improve process efficiency and cut costs associated with labour-intensive procedures like cleaning, sterilization, and maintenance of steel-based bioreactor systems. Single-use bioprocessing technology is used in a variety of biopharmaceutical applications, including filtration, mixing, purification, upstream expression, storage, and separation. Therefore, the single-use bioprocessing market is expanding. Rising manufacturing techniques' productive capacities, the removal of duplicate processes, direct cost savings from cheap labour and material costs, and reduced energy consumption and water use are all contributing reasons to the market's expansion.

Challenges:

There are currently no clear rules or guidelines governing the contamination of single-use bioprocessing systems by extractables and leachables. Leachables are substances that seep into drug products from packaging, closures, and manufacturing elements, and Leachables can be viewed as a subset of extractable as a result. These extractables and leachables are undesirable goods. Single-use bioprocessing goods frequently experience contamination from the container due to leachables because they are constructed of processed plastic materials. In light of their possible effects on product quality and patient health, considerable concerns regarding extractables and leachables resulting from the components of single-use bioprocessing systems may restrain market expansion. 

Regional Trends:

During the forecast period, North America (the United States, Canada, and Mexico) is expected to lead the market for single-use upstream bioprocessing. The market for single-use bioprocessing is being adopted due to the growing need for biopharmaceuticals and its benefits, including quick deployment, low risk of product cross-contamination, high energy efficiency, and low risk of product cross-contamination, high energy efficiency, and low water usage. The single-use upstream bioprocessing market in North America is anticipated to be dominated by the United States. The development of breakthrough single-use bioprocessing technologies in industrialized nations like the U.S. and Canada, the aging population, and the growing preference for bioactive compounds are all significant market growth drivers in this region.

Recent Developments:

  • In September 2020, Thermo Fisher Scientific expanded its St. Louis facility's capacity for biologics development and production, cell and gene therapy, and pharma product development by investing more than USD 475 million in new capabilities.
  • In March 2020, Danaher Corporation announced the completion of its acquisition of the Biopharma business from the Life Sciences division of General Electric Company. The company will be a stand-alone operating company within Danaher's Life Sciences division and will be a part of Danaher under the name Cytiva.

Chapter 1. Methodology and Scope

1.1. Research Methodology

1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Single-use Upstream Bioprocessing Market Snapshot

Chapter 4. Global Single-use Upstream Bioprocessing Market Variables, Trends & Scope

4.1. Market Segmentation & Scope

4.2. Drivers

4.3. Challenges

4.4. Trends

4.5. Investment and Funding Analysis

4.6. Industry Analysis – Porter’s Five Forces Analysis

4.7. Competitive Landscape & Market Share Analysis

4.8. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: By Product Estimates & Trend Analysis

5.1. By Product & Market Share, 2020 & 2030

5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Product:

5.2.1. Single-use Bioreactors

5.2.2. Single-use Mixers

5.2.3. Single-use Media Bags

5.2.4. Single-use Filters

5.2.5. Single-use Sampling Systems

5.2.6. Single-use Connectors

5.2.7. Others

Chapter 6. Market Segmentation 2: By Scale Estimates & Trend Analysis

6.1. By Scale & Market Share, 2020 & 2030

6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By Scale:

6.2.1. Preclinical / Clinical

6.2.2. Commercial

Chapter 7. Market Segmentation 3: By End-Use Estimates & Trend Analysis

7.1. By End-Use & Market Share, 2020 & 2030

7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2030 for the following By End-Use:

7.2.1. Biopharmaceutical Manufacturer

7.2.2. CMOs & CROs

Chapter 8. Single-use Upstream Bioprocessing Market Segmentation 4: Regional Estimates & Trend Analysis

8.1. North America

8.1.1. North America Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts By Product, 2020-2030

8.1.2. North America Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts By Scale, 2020-2030

8.1.3. North America Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by End-Use, 2020-2030

8.1.4. North America Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by country, 2020-2030

8.2. Europe

8.2.1. Europe Single-use Upstream Bioprocessing Market revenue (US$ Million) By Product, 2020-2030

8.2.2. Europe Single-use Upstream Bioprocessing Market revenue (US$ Million) By Scale, 2020-2030

8.2.3. Europe Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by End-Use, 2020-2030

8.2.4. Europe Single-use Upstream Bioprocessing Market revenue (US$ Million) by country, 2020-2030

8.3. Asia Pacific

8.3.1. Asia Pacific Single-use Upstream Bioprocessing Market revenue (US$ Million) By Product, 2020-2030

8.3.2. Asia Pacific Single-use Upstream Bioprocessing Market revenue (US$ Million) By Scale, 2020-2030

8.3.3. Asia Pacific Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by End-Use, 2020-2030

8.3.4. Asia Pacific Single-use Upstream Bioprocessing Market revenue (US$ Million) by country, 2020-2030

8.4. Latin America

8.4.1. Latin America Single-use Upstream Bioprocessing Market revenue (US$ Million) By Product, (US$ Million)

8.4.2. Latin America Single-use Upstream Bioprocessing Market revenue (US$ Million) By Scale, (US$ Million)

8.4.3. Latin America Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by End-Use, 2020-2030

8.4.4. Latin America Single-use Upstream Bioprocessing Market revenue (US$ Million) by country, 2020-2030

8.5. Middle East & Africa

8.5.1. Middle East & Africa Single-use Upstream Bioprocessing Market revenue (US$ Million) By Product, (US$ Million)

8.5.2. Middle East & Africa Single-use Upstream Bioprocessing Market revenue (US$ Million) By Scale, (US$ Million)

8.5.3. Middle East & Africa Single-use Upstream Bioprocessing Market revenue (US$ Million) estimates and forecasts by End-Use, 2020-2030

8.5.4. Middle East & Africa Single-use Upstream Bioprocessing Market revenue (US$ Million) by country, 2020-2030

Chapter 9. Competitive Landscape

9.1. Major Mergers and Acquisitions/Strategic Alliances

9.2. Company Profiles

9.2.1. Danaher Corporation (Cytiva),

9.2.2. Sartorius AG,

9.2.3. Thermo Fisher Scientific, Inc.,

9.2.4. Merck KGaA,

9.2.5. Corning Incorporated,

9.2.6. Pall Corporation,

9.2.7. General Electric Company (GE Healthcare)

9.2.8. Eppendorf AG,

9.2.9. Rentschler Biopharma SE

9.2.10. Lonza,

9.2.11. Meissner Filtration Products, Inc.,

9.2.12. JM BioConnect,

9.2.13. Boehringer Ingelheim GmbH

9.2.14. Infors A

9.2.15. Other Prominent Players

Segmentation of Single-use Upstream Bioprocessing Market-

By Product

  • Single-use Bioreactors
  • Single-use Mixers
  • Single-use Media Bags
  • Single-use Filters
  • Single-use Sampling Systems
  • Single-use Connectors
  • Others

By Scale

  • Preclinical / Clinical
  • Commercial

By End-Use

  • Biopharmaceutical Manufacturer
  • CMOs & CROs

By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa

Rest of Middle East and Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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USD 34.54 billion by 2030

CAGR of 16.6% during the forecast period.

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