The Antisense Oligonucleotide Therapeutics Market Size is valued at USD 2.0 Bn in 2023 and is predicted to reach USD 5.71 Bn by the year 2031 at a 14.0% CAGR during the forecast period for 2024-2031.
Antisense oligonucleotide is crucial in present medicine because it inhibits the expression of disease-causing genes by acting on messenger RNA before the protein is produced. This is attributed to rising antisense drug acceptability, increased R&D funding, rising neurodegenerative disorders, and an ageing population. The antisense oligonucleotides market will benefit from a high number of regulatory approvals from the Food and Drug Administration (FDA), for the use of innovative antisense oligonucleotides medications. Furthermore, mergers and acquisitions to enhance their product offerings are expected to be a major driver for the worldwide antisense oligonucleotides market over the upcoming years.
However, the high cost of antisense oligonucleotide therapeutics and the availability of synthetic chemicals are factors projected to limit the overall growth of the antisense oligonucleotide therapeutics market over the coming years. In addition, developing a new set of unique regulatory requirements is a difficulty that is inhibiting the worldwide antisense oligonucleotide market's growth. Also, Investments by prominent players are factors expected to create lucrative growth opportunities in terms of revenue for players operating in the global Antisense Oligonucleotide Therapeutics market over the forecast period.
Competitive Landscape
Some major key players in the Antisense Oligonucleotide Therapeutics Market:
- Sarepta Therapeutics
- Biogen
- Alnylam Pharmaceuticals, Inc
- Antisense Therapeutics Limited
- Sarna Therapeutics GmbH
- Arrowhead Pharmaceuticals, Inc.
- Atlantic Pharmaceuticals, Inc.
- Enzo Pharmaceuticals, Inc.
- Bio-Path Holdings, Inc.
- Gene Signal International SA
- GlaxoSmithKline plc
- Gerona Corporation
- Gradualist
- ICO Therapeutics
- Aptos Biosciences
- Marina Biotech
- mirage Therapeutics, Inc.
- Synodic, Inc.
- Oncogene Pharmaceuticals Inc.
- Pharm axis Ltd
- Regulus Therapeutics Inc.,
- Reran Pharmaceuticals, Inc.
- RI Pharmaceuticals
- Ionis Pharmaceuticals
- ProQR Therapeutics
- Sterna Biologicals
- Wave Life Sciences
- Other Prominent Players
Market Segmentation:
The antisense oligonucleotide Therapeutics market is segmented into, ASO Generation, Phase of Development, Route of Administration, Type of Therapy, Indications, Drug Type. The ASO generation, encompassing first-generation, second-generation, third-generation, and next-generation ASOs. The phase of development spans from commercial, clinical, preclinical, to discovery stage. Routes of administration vary, including subcutaneous, intravenous, intrathecal, intravitreal, and other methods. Antisense therapies are further categorized by type of therapy, such as monotherapy, combination therapy, or both. Indications for ASO treatments include Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, Transthyretin Amyloidosis, Familial Chylomicronemia Syndrome, Amyotrophic Lateral Sclerosis, and other conditions. The drug types associated with these therapies include Eleplinsen, Nusinersen, Inotersen, Volanesorsen, Golodirsen, Viltolarsen, Casimersen, Tofersen, and others.
Based on Type of Therapy, the monotherapy segment is accounted as a major contributor in the Antisense Oligonucleotide Therapeutics market.
The Monotherapy category is expected to hold a major share in the global Antisense Oligonucleotide Therapeutics market. The market is expected to increase due to a rise in regulatory approvals of monotherapy medications. Furthermore, the increased prevalence of prostate cancer is expected to drive the market forward during the forecast period.
In the region, the North America Antisense Oligonucleotide Therapeutics market holds a significant revenue share.
The North America Antisense Oligonucleotide Therapeutics market is expected to register the highest market share in terms of revenue soon. Several biotechnology companies have made significant expenditures on the development of RNAi therapeutics. Big pharmaceutical companies have gone into partnership or license arrangements with several smaller companies to profit from the predicted revenue increase in this industry over the projection period. Several medication candidates now undergoing clinical trials have shown promising results and are moving forward in the development process. If such studies continue to yield positive results, the North American market is likely to see a significant demand increase throughout the forecast period.
Europe is expected to be the dominant region in the global antisense oligonucleotides market over the forecast period. This is due to the region's rising approval of novel antisense oligonucleotide medications. In addition to enhancing their product offers in antisense oligonucleotides, key companies in Europe are focusing on strategic mergers and acquisitions.
Antisense Oligonucleotide Therapeutics Market Report Scope
Report Attribute |
Specifications |
Market Size Value In 2023 |
USD 2.0 Bn |
Revenue Forecast In 2031 |
USD 5.71 Bn |
Growth Rate CAGR |
CAGR of 14.0% from 2024 to 2031 |
Quantitative Units |
Representation of revenue in US$ Million and CAGR from 2024 to 2031 |
Historic Year |
2019 to 2023 |
Forecast Year |
2024-2031 |
Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
Segments Covered |
By ASO Generation, By Phase of Development, By Route of Administration, By Type of Therapy, By Indications, By Drug Type |
Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
Country Scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South East Asia; South Korea |
Competitive Landscape |
Sarepta Therapeutics, Biogen, Alnylam Pharmaceuticals, Antisense Therapeutics, Sarna Therapeutics, Arrowhead Pharmaceuticals, Atlantic Pharmaceuticals, Enzo Pharmaceuticals, Bio-Path Holdings, Gene Signal International, GlaxoSmithKline, Gerona Corporation, Gradualist, ICO Therapeutics, Aptos Biosciences, Marina Biotech, Mirage Therapeutics, Synodic, Oncogene Pharmaceuticals, Pharm Axis, Regulus Therapeutics, Reran Pharmaceuticals, RI Pharmaceuticals, Ionis Pharmaceuticals, ProQR Therapeutics, Sterna Biologicals, Wave Life Sciences, and Other Prominent Players. |
Customization Scope |
Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape. |
Pricing And Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |