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Global Antisense Oligonucleotide Therapeutics Market

Antisense Oligonucleotide Therapeutics Market Size, Share & Trends Analysis Report, Analysis Report By By ASO Generation (First-Generation, Second-Generation, Third-Generation, Next-Generation), By Phase of Development, By Route of Administration, By Type of Therapy, By Indications, and By Drug Type, By Region, Forecasts, 2024-2031

Report ID : 1245 | Published : 2024-10-03 | Pages: 180 | Format: PDF/EXCEL

The Antisense Oligonucleotide Therapeutics Market Size is valued at USD 2.0 Bn in 2023 and is predicted to reach USD 5.71 Bn by the year 2031 at a 14.0% CAGR during the forecast period for 2024-2031.

antisense oligonucleotide

Antisense oligonucleotide is crucial in present medicine because it inhibits the expression of disease-causing genes by acting on messenger RNA before the protein is produced. This is attributed to rising antisense drug acceptability, increased R&D funding, rising neurodegenerative disorders, and an ageing population. The antisense oligonucleotides market will benefit from a high number of regulatory approvals from the Food and Drug Administration (FDA), for the use of innovative antisense oligonucleotides medications. Furthermore, mergers and acquisitions to enhance their product offerings are expected to be a major driver for the worldwide antisense oligonucleotides market over the upcoming years.

However, the high cost of antisense oligonucleotide therapeutics and the availability of synthetic chemicals are factors projected to limit the overall growth of the antisense oligonucleotide therapeutics market over the coming years. In addition, developing a new set of unique regulatory requirements is a difficulty that is inhibiting the worldwide antisense oligonucleotide market's growth. Also, Investments by prominent players are factors expected to create lucrative growth opportunities in terms of revenue for players operating in the global Antisense Oligonucleotide Therapeutics market over the forecast period.

Competitive Landscape

Some major key players in the Antisense Oligonucleotide Therapeutics Market:

  • Sarepta Therapeutics
  • Biogen
  • Alnylam Pharmaceuticals, Inc
  • Antisense Therapeutics Limited
  • Sarna Therapeutics GmbH
  • Arrowhead Pharmaceuticals, Inc.
  • Atlantic Pharmaceuticals, Inc.
  • Enzo Pharmaceuticals, Inc.
  • Bio-Path Holdings, Inc.
  • Gene Signal International SA
  • GlaxoSmithKline plc
  • Gerona Corporation
  • Gradualist
  • ICO Therapeutics
  • Aptos Biosciences
  • Marina Biotech
  • mirage Therapeutics, Inc.
  • Synodic, Inc.
  • Oncogene Pharmaceuticals Inc.
  • Pharm axis Ltd
  • Regulus Therapeutics Inc., 
  • Reran Pharmaceuticals, Inc.
  • RI Pharmaceuticals
  • Ionis Pharmaceuticals
  • ProQR Therapeutics
  • Sterna Biologicals
  • Wave Life Sciences
  • Other Prominent Players

Market Segmentation:

The antisense oligonucleotide Therapeutics market is segmented into, ASO Generation, Phase of Development, Route of Administration, Type of Therapy, Indications, Drug Type. The ASO generation, encompassing first-generation, second-generation, third-generation, and next-generation ASOs. The phase of development spans from commercial, clinical, preclinical, to discovery stage. Routes of administration vary, including subcutaneous, intravenous, intrathecal, intravitreal, and other methods. Antisense therapies are further categorized by type of therapy, such as monotherapy, combination therapy, or both. Indications for ASO treatments include Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, Transthyretin Amyloidosis, Familial Chylomicronemia Syndrome, Amyotrophic Lateral Sclerosis, and other conditions. The drug types associated with these therapies include Eleplinsen, Nusinersen, Inotersen, Volanesorsen, Golodirsen, Viltolarsen, Casimersen, Tofersen, and others.

Based on Type of Therapy, the monotherapy segment is accounted as a major contributor in the Antisense Oligonucleotide Therapeutics market.

The Monotherapy category is expected to hold a major share in the global Antisense Oligonucleotide Therapeutics market. The market is expected to increase due to a rise in regulatory approvals of monotherapy medications. Furthermore, the increased prevalence of prostate cancer is expected to drive the market forward during the forecast period.

In the region, the North America Antisense Oligonucleotide Therapeutics market holds a significant revenue share.

The North America Antisense Oligonucleotide Therapeutics market is expected to register the highest market share in terms of revenue soon. Several biotechnology companies have made significant expenditures on the development of RNAi therapeutics. Big pharmaceutical companies have gone into partnership or license arrangements with several smaller companies to profit from the predicted revenue increase in this industry over the projection period. Several medication candidates now undergoing clinical trials have shown promising results and are moving forward in the development process. If such studies continue to yield positive results, the North American market is likely to see a significant demand increase throughout the forecast period.

Europe is expected to be the dominant region in the global antisense oligonucleotides market over the forecast period. This is due to the region's rising approval of novel antisense oligonucleotide medications. In addition to enhancing their product offers in antisense oligonucleotides, key companies in Europe are focusing on strategic mergers and acquisitions.

Antisense Oligonucleotide Therapeutics Market Report Scope

Report Attribute

Specifications

Market Size Value In 2023

USD 2.0 Bn

Revenue Forecast In 2031

USD 5.71 Bn

Growth Rate CAGR

CAGR of 14.0% from 2024 to 2031

Quantitative Units

Representation of revenue in US$ Million and CAGR from 2024 to 2031

Historic Year

2019 to 2023

Forecast Year

2024-2031

Report Coverage

The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends

Segments Covered

By ASO Generation, By Phase of Development, By Route of Administration, By Type of Therapy, By Indications, By Drug Type

Regional Scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country Scope

U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South East Asia; South Korea

Competitive Landscape

Sarepta Therapeutics, Biogen, Alnylam Pharmaceuticals, Antisense Therapeutics, Sarna Therapeutics, Arrowhead Pharmaceuticals, Atlantic Pharmaceuticals, Enzo Pharmaceuticals, Bio-Path Holdings, Gene Signal International, GlaxoSmithKline, Gerona Corporation, Gradualist, ICO Therapeutics, Aptos Biosciences, Marina Biotech, Mirage Therapeutics, Synodic, Oncogene Pharmaceuticals, Pharm Axis, Regulus Therapeutics, Reran Pharmaceuticals, RI Pharmaceuticals, Ionis Pharmaceuticals, ProQR Therapeutics, Sterna Biologicals, Wave Life Sciences, and Other Prominent Players.

Customization Scope

Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape.

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Chapter 1.          Methodology and Scope

1.1.        Research Methodology

1.2.        Research Scope & Assumptions

Chapter 2.          Executive Summary

Chapter 3.          Global Antisense Oligonucleotides Market Snapshot

Chapter 4.          Global Antisense Oligonucleotides Market Variables, Trends & Scope

4.1.        Market Segmentation & Scope

4.2.        Drivers

4.3.        Challenges

4.4.        Opportunities

4.5.        Trends

4.6.        Investment and Funding Analysis

4.7.        Industry Analysis – Porter’s Five Forces Analysis

4.8.        USFDA Approved Antisense Oligonucleotide Products

4.9.        Clinical Trial Analysis

4.10.     Key Merger & Acquisitions, Partnership in the Market

4.11.     Competitive Landscape & Market Share Analysis

4.12.     Impact of Covid-19 Analysis

Chapter 5.          Market Segmentation 1: By Type of Therapy, Estimates & Trend Analysis

5.1.        By Type of Therapy, & Market Share, 2023 & 2031

5.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By Type of Therapy:

5.2.1.    Monotherapy

5.2.2.    Combination Therapy

5.2.3.    Both

Chapter 6.          Market Segmentation 2: By Route of Administration Estimates & Trend Analysis

6.1.        By Route of Administration & Market Share, 2023 & 2031

6.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By Route of Administration:

6.2.1.    Subcutaneous

6.2.2.    Intravenous

6.2.3.    Intrathecal

6.2.4.    Intravitreal

6.2.5.    Others

Chapter 7.          Market Segmentation 3: By Phase of Development Estimates & Trend Analysis

7.1.        By Phase of Development & Market Share, 2023 & 2031

7.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By Phase of Development:

7.2.1.    Commercial

7.2.2.    Clinical

7.2.3.    Preclinical

7.2.4.    Discovery Stage

Chapter 8.          Market Segmentation 4: By ASO Generation Estimates & Trend Analysis

8.1.        By ASO Generation & Market Share, 2023 & 2031

8.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By ASO Generation:

8.2.1.    First-Generation

8.2.2.    Second-Generation

8.2.3.    Third-Generation

8.2.4.    Next-Generation

Chapter 9.          Market Segmentation 5: By Drug Type Estimates & Trend Analysis

9.1.        By Drug Type & Market Share, 2023 & 2031

9.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By Drug Type:

9.2.1.    Eleplinsen

9.2.2.    Nusinersen

9.2.3.    Inotersen

9.2.4.    Volanesorsen

9.2.5.    Golodirsen

9.2.6.    Viltolarsen

9.2.7.    Casimersen

9.2.8.    Tofersen

9.2.9.    Others

Chapter 10.        Market Segmentation 6: By Indication Estimates & Trend Analysis

10.1.     By Indication & Market Share, 2023 & 2031

10.2.     Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following By Indication:

10.2.1.  Duchenne Muscular Dystrophy

10.2.2.  Spinal Muscular Atrophy

10.2.3.  Transthyretin Amyloidosis

10.2.4.  Familial Chylomicronemia Syndrome

10.2.5.  Amyotrophic Lateral Sclerosis

10.2.6.  Others

Chapter 11.        Antisense Oligonucleotides Market Segmentation 7: Regional Estimates & Trend Analysis

11.1.     North America

11.1.1.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Type of Therapy, 2019-2031

11.1.2.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Route of Administration, 2019-2031

11.1.3.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Phase of Development, 2019-2031

11.1.4.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By ASO Generation, 2019-2031

11.1.5.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Drug Type, 2019-2031

11.1.6.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Indication, 2019-2031

11.1.7.  North America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts by Country, 2019-2031

11.1.7.1.             U.S.

11.1.7.2.             Canada

11.2.     Europe

11.2.1.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Type of Therapy, 2019-2031

11.2.2.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Route of Administration, 2019-2031

11.2.3.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Phase of Development, 2019-2031

11.2.4.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By ASO Generation, 2019-2031

11.2.5.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Drug Type, 2019-2031

11.2.6.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Indication, 2019-2031

11.2.7.  Europe Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts by Country, 2019-2031

11.2.7.1.             Germany

11.2.7.2.             U.K.

11.2.7.3.             France

11.2.7.4.             Italy

11.2.7.5.             Spain

11.2.7.6.             Rest of Europe

11.3.     Asia Pacific

11.3.1.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Type of Therapy, 2019-2031

11.3.2.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Route of Administration, 2019-2031

11.3.3.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Phase of Development, 2019-2031

11.3.4.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By ASO Generation, 2019-2031

11.3.5.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Drug Type, 2019-2031

11.3.6.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Indication, 2019-2031

11.3.7.  Asia Pacific Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts by Country, 2019-2031

11.3.7.1.             Japan

11.3.7.2.             China

11.3.7.3.             India

11.3.7.4.             Australia

11.3.7.5.             South Korea

11.3.7.6.             Southeast Asia

11.3.7.7.             Hong Kong

11.3.7.8.             Rest of Asia Pacific

11.4.     Latin America

11.4.1.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Type of Therapy, 2019-2031

11.4.2.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Route of Administration, 2019-2031

11.4.3.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Phase of Development, 2019-2031

11.4.4.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By ASO Generation, 2019-2031

11.4.5.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Drug Type, 2019-2031

11.4.6.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Indication, 2019-2031

11.4.7.  Latin America Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts by Country, 2019-2031

11.4.7.1.             Brazil

11.4.7.2.             Mexico

11.4.7.3.             Rest of Latin America

11.5.     Middle East & Africa

11.5.1.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Type of Therapy, 2019-2031

11.5.2.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Route of Administration, 2019-2031

11.5.3.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Phase of Development, 2019-2031

11.5.4.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By ASO Generation, 2019-2031

11.5.5.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Drug Type, 2019-2031

11.5.6.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts By Indication, 2019-2031

11.5.7.  Middle East & Africa Antisense Oligonucleotides Market revenue (US$ Million) estimates and forecasts by Country, 2019-2031

11.5.7.1.             GCC Countries

11.5.7.2.             South Africa

11.5.7.3.             Rest of MEA

Chapter 12.        Competitive Landscape

12.1.     Major Mergers and Acquisitions/Strategic Alliances

12.2.     Company Profiles

12.2.1.  Sarepta Therapeutics

12.2.2.  Biogen

12.2.3.  Alnylam Pharmaceuticals, Inc

12.2.4.  Antisense Therapeutics Limited

12.2.5.  Sarna Therapeutics GmbH

12.2.6.  Arrowhead Pharmaceuticals, Inc.

12.2.7.  Atlantic Pharmaceuticals, Inc.

12.2.8.  Enzo Pharmaceuticals, Inc.

12.2.9.  Bio-Path Holdings, Inc.

12.2.10.              Gene Signal International SA

12.2.11.              GlaxoSmithKline plc

12.2.12.              Gerona Corporation

12.2.13.              Gradualist

12.2.14.              ICO Therapeutics

12.2.15.              Aptos Biosciences

12.2.16.              Marina Biotech

12.2.17.              mirage Therapeutics, Inc.

12.2.18.              Synodic, Inc.

12.2.19.              Oncogene Pharmaceuticals Inc.

12.2.20.              Pharm axis Ltd

12.2.21.              Regulus Therapeutics Inc., Reran Pharmaceuticals, Inc.

12.2.22.              RI Pharmaceuticals

12.2.23.              Ionis Pharmaceuticals

12.2.24.              ProQR Therapeutics

12.2.25.              Sterna Biologicals

12.2.26.              Wave Life Sciences

12.2.27.              Other Prominent Players

Segmentation of Antisense Oligonucleotide Therapeutics Market-

Antisense Oligonucleotides Therapeutics Market By Type of Therapy

  • Monotherapy
  • Combination Therapy
  • Both

antisense oligonucliotide

Antisense Oligonucleotides Therapeutics Market By ASO Generation

  • First-Generation
  • Second-Generation
  • Third-Generation
  • Next-Generation

Antisense Oligonucleotides Therapeutics Market By Phase of Development

  • Commercial
  • Clinical
  • Preclinical
  • Discovery Stage

Antisense Oligonucleotides Therapeutics Market By  Route of Administration

  • Subcutaneous
  • Intravenous
  • Intrathecal
  • Intravitreal
  • Others

Antisense Oligonucleotides Therapeutics Market By Indications

  • Duchenne Muscular Dystrophy
  • Spinal Muscular Atrophy
  • Transthyretin Amyloidosis
  • Familial Chylomicronemia Syndrome
  • Amyotrophic Lateral Sclerosis
  • Others

Antisense Oligonucleotides Therapeutics Market By Drug Type

  • Eleplinsen
  • Nusinersen
  • Inotersen
  • Volanesorsen
  • Golodirsen
  • Viltolarsen
  • Casimersen
  • Tofersen
  • Others

Antisense Oligonucleotides Therapeutics Market By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa

Rest of Middle East and Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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Frequently Asked Questions

What is the Antisense Oligonucleotide Therapeutics Market Growth?

Sarepta Therapeutics, Biogen, Alnylam Pharmaceuticals, Antisense Therapeutics, Sarna Therapeutics, Arrowhead Pharmaceuticals, Atlantic Pharmaceuticals

The Antisense Oligonucleotide Therapeutics Market Size is valued at USD 2.0 Bn in 2023 and is predicted to reach USD 5.71 Bn by the year 2031

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