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Global Antibody Drug Conjugates (Adcs) – Linker And Conjugation Technologies Market

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Size, Share & Trends Analysis Report, Distribution by Generation of Technology (Third-Generation, Second-Generation and Next-Generation), Type of Conjugation (Chemical, Chemoenzymatic and Chemical), Type of Linker, Type of Payment Model Adopted, By Region, Forecasts, 2024-2031

Report ID : 1179 | Published : 2024-06-15 | Pages: 190 | Format: PDF/EXCEL

The Global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market size is valued at USD 1.0 billion in 2023 and is predicted to reach USD 2.33 billion by the year 2031 at an 11.31% CAGR during the forecast period for 2024-2031.

Key Industry Insights & Findings from the Report:

  • Innovations in site-specific conjugation and novel linker chemistries contribute to the development of more effective and reliable ADCs.
  • Collaboration between pharmaceutical companies, biotechnology firms, and academic institutions fosters innovation and accelerates the development of ADCs.
  • North America dominated the market and accounted for a global revenue share in 2023.
  • The biological mechanisms underlying ADCs' efficacy and potential side effects are not yet fully understood. This limited understanding can lead to unpredictable clinical outcomes and poses challenges in optimizing ADC designs.

 adc linker and conjugates

In recent years cancer has cancer has emerged as a major public health problem in the world and a few of the most common forms are breast cancer, lung cancer, prostate cancer and leukemia. Antibody drug conjugates (ADCs) signify a promising and an efficient strategy for targeted cancer therapy. ADCs are being developed as a new class of highly potent bio-pharmaceutical drugs, and characterized as an advanced therapeutic application that has collective properties of monoclonal antibodies (mAbs) with the potent small molecule drugs (cytotoxin). At present times, as research, development and approval of ADC-based technology moves forward, ADC-based chemotherapy drugs will impact the current chemotherapy market. It is further expected to improve the quality of life for cancer patients and influence research and development in other pharmaceutical markets.

The factor which is significantly boosting the growth of the global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies market is the rise in the incidence of cancer coupled with growing geriatric population. The increase in obese population and increasing research activities on antibody therapies is catalyzing the growth of Antibody drug conjugates industry. Also, increased investments by governments and private organizations for the preclinical research, and the cumulative research on oncology diseases are contributing to the growth of the global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies market. Increased focus of medical professionals on development of alternative therapies and treatments owing to the continually growing prevalence of cancer is projected to create growth opportunities during the forecast period.

Competitive Landscape

Some major key players in the Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market:

  • Ambrx
  • Catalent Biologics
  • Mersana Therapeutics
  • Seagen
  • Sutro Biopharma
  • Iksuda Therapeutics
  • Heidelberg Pharma
  • LinXis Biopharmaceuticals
  • NBE-Therapeutics
  • Alteogen
  • LegoChem Biosciences
  • Araris Biotech AG
  • Ajinomoto Co.
  • Antikor Biopharma
  • Iksuda Therapeutics Ltd
  • SynAffix
  • Seattle Genetics, Inc
  • ImmunoGen
  • Immunomedics
  • Mersana Therapeutics
  • ADC therapeutics

Market Segmentation

The Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market is segmented distribution by generation of technology, type of conjugation, type of linker, type of payment model adopted. Based distribution by generation of technology, the market segmented into third-generation, second-generation and next-generation. Type of Conjugation, the market segmented into Chemical, Chemoenzymatic and Chemical, Type of Linker, the market segmented into Cleavable and non-cleavable, Type of Payment Model Adopted the market segmented into upfront payments and milestone payments.

Recent Developments:

  • In January 2024, Ambrx, Johnson & Johnson, declared today that it has reached a final agreement to buy Ambrx Biopharma, Inc., also known as Ambrx, a biopharmaceutical company in clinical stage that uses a unique platform for synthetic biology technology to create and develop next-generation antibody drug conjugates (ADCs). The deal is an all-cash merger, with a total equity value of about $2.0 billion, or $1.9 billion net of estimated cash acquired.

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Report Scope

Report Attribute

Specifications

Market size value in 2023

USD 6.60 Bn

Revenue Forecast in 2031

USD 2.33 Bn

Growth rate CAGR

CAGR of 11.31 % from 2024 to 2031

Quantitative units

Representation of revenue in US$ Million and CAGR from 2024 to 2031

Historic Year

2019 to 2023

Forecast Year

2024-2031

Report Coverage

The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends

Segments Covered

By Distribution by Generation of Technology, Type of Conjugation, Type of Linker, Type of Payment Model Adopted

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South Korea; South East Asia

Competitive Landscape

Seattle Genetics, Inc., ImmunoGen, Ambrx, Catalent Biologics, Immunomedics, Mersana Therapeutics, Sutro Biopharma, Iksuda Therapeutics, LegoChem Biosciences, LinXis, ADC therapeutics and Other Prominent Players.

Customization scope

Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape.

Pricing and available payment methods

Explore pricing alternatives that are customized to your particular study requirements.

 

Chapter 1. Methodology and Scope

1.1. Research Methodology
1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Snapshot

Chapter 4. Global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Industry Analysis – Porter’s Five Forces Analysis
4.7. Competitive Landscape & Market Share Analysis
4.8. Impact of Covid-19 Analysis

Chapter 5. Market Segmentation 1: Distribution by Generation of Technology of Molecule Estimates & Trend Analysis
5.1. Distribution by Generation of Technology of Molecule & Market Share, 2023 & 2031
5.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following Distribution by Generation of Technology of Molecule:

5.2.1. Third-Generation
5.2.2. Second-Generation
5.2.3. Next-Generation

Chapter 6. Market Segmentation 2: Type of Conjugation Estimates & Trend Analysis
6.1. Type of Conjugation & Market Share, 2023 & 2031
6.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Conjugation:

6.2.1. Chemical
6.2.2. Chemoenzymatic and Chemical

Chapter 7. Market Segmentation 3: Type of Linker Estimates & Trend Analysis
7.1. Type of Linker & Market Share, 2023 & 2031
7.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Linker:

7.2.1. Cleavable
7.2.2. Non-Cleavable

Chapter 8. Market Segmentation 4: Type of Payment Model Adopted Estimates & Trend Analysis
8.1. Type of Conjugation & Market Share, 2023 & 2031
8.2. Market Size (Value (US$ Mn)) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Payment Model Adopted:

8.2.1. Upfront Payments
8.2.2. Milestone Payments

Chapter 9. Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Segmentation 4: Regional Estimates & Trend Analysis

9.1. North America
9.1.1. North America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Distribution by Generation of Technology of Molecule, 2024-2031
9.1.2. North America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Conjugation, 2024-2031
9.1.3. North America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Linker, 2024-2031
9.1.4. North America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031
9.1.5. North America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.2. Europe
9.2.1. Europe Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Distribution by Generation of Technology of Molecule, 2024-2031
9.2.2. Europe Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Conjugation, 2024-2031
9.2.3. Europe Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Linker, 2024-2031
9.2.4. Europe Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031
9.2.5. Europe Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.3. Asia Pacific
9.3.1. Asia Pacific Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Distribution by Generation of Technology of Molecule, 2024-2031
9.3.2. Asia Pacific Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Conjugation, 2024-2031
9.3.3. Asia-Pacific Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031
9.3.4. Asia-Pacific Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031

9.3.5. Asia Pacific Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.4. Latin America
9.4.1. Latin America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Distribution by Generation of Technology of Molecule, 2024-2031
9.4.2. Latin America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Conjugation, 2024-2031
9.4.3. Latin America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Linker, 2024-2031
9.4.4. Latin America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031
9.4.5. Latin America Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

9.5. Middle East & Africa
9.5.1. Middle East & Africa Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Distribution by Generation of Technology of Molecule, 2024-2031
9.5.2. Middle East & Africa Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Conjugation, 2024-2031
9.5.3. Middle East & Africa Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Linker, 2024-2031
9.5.4. Middle East & Africa Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts Type of Payment Model Adopted, 2024-2031
9.5.5. Middle East & Africa Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031


Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles

10.2.1. 2 Ambrx
10.2.2. Catalent Biologics
10.2.3. Mersana Therapeutics
10.2.4. Seagen
10.2.5. Sutro Biopharma
10.2.6. Iksuda Therapeutics
10.2.7. Heidelberg Pharma
10.2.8. LinXis Biopharmaceuticals
10.2.9. NBE-Therapeutics
10.2.10. Alteogen
10.2.11. LegoChem Biosciences
10.2.12. Araris Biotech AG
10.2.13. Ajinomoto Co.
10.2.14. Antikor Biopharma
10.2.15. Iksuda Therapeutics Ltd
10.2.16. SynAffix
10.2.17. Seattle Genetics, Inc
10.2.18. ImmunoGen
10.2.19. Immunomedics
10.2.20. Mersana Therapeutics
10.2.21. ADC therapeutics
10.2.22. Other Market Players

Global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Segmentation

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market- Distribution by Generation of Technology

  • Third-Generation
  • Second-Generation
  • Next-Generation

ADC linker and conjugates

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market- Type of Conjugation

  • Chemical
  • Chemoenzymatic and Chemical

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market- Type of Linker

  • Cleavable
  • Non-Cleavable

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market- Type of Payment Model Adopted

  • Upfront Payments
  • Milestone Payments

Global Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Based on Region

Europe

  • U.K.
  • Germany
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe

North America

  • U.S.
  • Canada

Asia Pacific

  • India
  • China
  • Japan
  • South Korea
  • Australia & New Zealand

Latin America

  • Brazil
  • Mexico
  • Rest of Latin America

Middle East & Africa

  • GCC Countries
  • South Africa
  • Rest of Middle East & Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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Frequently Asked Questions

What is the Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market Growth?

Seattle Genetics, Inc., ImmunoGen, Ambrx, Catalent Biologics, Immunomedics, Mersana Therapeutics, Sutro Biopharma, Iksuda Therapeutics, LegoChem Biosc

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