NGS Sample Preparation Market Size, Share & Trends Analysis Report By workflow (NGS Library Preparation Kits, Semi-Automated Library Preparation, Automated Library Preparation And Clonal Amplification), By Application, By End-User, By Region, And By Segment Forecasts, 2024-2031.

Report Id: 1424 Pages: 175 Last Updated: 12 March 2024 Format: PDF / PPT / Excel / Power BI
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The NGS Sample Preparation Market Size is valued at 4.10 Billion in 2023 and is predicted to reach 9.51 Billion by the year 2031 at an 11.35 % CAGR during the forecast period for 2024-2031.

Key Industry Insights & Findings from the Report:

  • Expanding awareness of infectious diseases, decreasing sequencing costs, and growth in the field of genomics in NGS platforms are driving forces behind the market's expansion.
  • The NGS industry is predicted to substantially expand in the future, propelled by the increasing technological advancements in NGS devices and technologies.
  • North America dominated the market and accounted for a revenue share of global revenue in 2023.
  • The increased likelihood of discovering alterations without apparent impact on clinical significance is one of the major drawbacks of the NGS technology.

ngs sample preparation

Next-generation sequencing is one of the high-throughput DNA sequencing techniques that use the concept of massively parallel processing (NGS). Another name for it is "massively parallel sequencing." Different sequencing, chemical, and engineering setups are available for NGS platforms. NGS methods make it possible to determine RNA structures. NGS allowed for the rapid sequencing of the entire human genome in just one day. NGS technology has increased the precision and speed of genome sequencing.

Global market revenue growth is fueled by essential factors like growing acceptance for NGS in diagnostics due to lower costs of NGS products and the advent of low-cost sequencing methodologies. A few fundamental drivers driving the NGS Sample Preparation Market  growth include the increasing prevalence of genetic disorders of infectious and chronic diseases and using NGS in cancer diagnoses and therapy.

Additionally, it is anticipated that factors like improved products for producing high-quality libraries with a high yield for effective sequencing would create more attractive prospects for top companies and accelerate market expansion in the upcoming years. However, the high cost of NGS and strict NGS-related restrictions in some countries may limit the growth of this worldwide sector.

Competitive Landscape

Some major key players in the NGS Sample Preparation Market:

  • Illumina, Inc. (US),
  • Thermo Fisher Scientific Inc. (US),
  • PerkinElmer Inc. (US),
  • Hoffmann-La Roche Ltd. (Switzerland),
  • Agilent Technologies, Inc. (US),
  • Danaher (US),
  • Becton, Dickinson and Company (US),
  • Merck KGAA (Germany),
  • QIAGEN (Germany),
  • Bio-Rad Laboratories, Inc. (US),
  • Promega Corporation (US),
  • Eurofins Scientific (Luxembourg),
  • BGI (China),
  • 10x Genomics (US),
  • Sysmex Corporation (US),
  • Psomagen (US),
  • Zymo Research Corporation (US),
  • Takara Bio Inc. (Japan),
  • Novogene Co., Ltd. (China),
  • New England Biolabs (US),
  • Tecan Trading AG (US),
  • Oxford Nanopore Technologies PLC (UK),
  • PacBio (US),
  • Medgenome (US),
  • Swift Biosciences Inc. (US).

Market Segmentation:

The NGS Sample Preparation Market is segmented into Products & Services, Workflow, Sample Type, Method, Application and End-user. The Products & Services segment comprises Workstations/Instruments, Reagents & Consumables, and Services. According to workflow, the market is categorized into DNA Fragmentation & Library Preparation, Target Enrichment, and QC. The Sample Type segment includes DNA and RNA. By Method, the market is segmented as Manual Sample Preparation, Microfluidic Sample Preparation, and Automated Liquid Handling-based Sample Preparation. According to application, the market comprises Diagnostics, Drug Discovery, Agricultural & Animal Research, and Other applications. Lastly, the End User segment is categorized into Academic Institutes & Research Centers, Hospitals & Clinics, Pharma & Biotech Companies, and Other End Users.

DNA category accounted for the largest share of the sample type segment in NGS sample preparation market.

 

The DNA category dominated the market according to the sample type. The DNA segment is anticipated to experience expansion during the projected period due to an increasing number of cancer cases and greater spending on research and development for DNA samples.

The workstation/ instruments segment dominated the product & services segment in NGS sample preparation market in 2022.

 

Based on the product & services, The workstation/instruments segment record the largest market revenue share in 2022. The market growth is expected to be driven by the rising need for Next-Generation Sequencing (NGS) automation.

In 2022, the disease diagnostics segment generated the highest revenue in the application segment for NGS sample preparation market.

 

Based on the application, The diagnostics segment has generated the largest earnings in the application segment in 2022. A significant portion of the disease diagnostics sector can be ascribed to the growing existence of cancer worldwide and the early detection of several infectious diseases and monogenetic disorders, as well as its role in precision medicine.

The North American NGS Sample Preparation Market  holds a significant regional revenue share.

The North American NGS Sample Preparation Market  is expected to register the highest market share in revenue shortly due to several variables, including the growing need for diagnostic tools for detecting health disparities, public knowledge of accessible technologies, the concentration of market players in the United States, and the expanding burden of infectious diseases and chronic diseases in the area.

The biotechnology and auxiliary markets in this region are also being driven by considerable R&D expenditure, a technologically advanced healthcare research framework, and the presence of significant companies. In addition, Asia Pacific is projected to grow rapidly in the global NGS Sample Preparation Market . The predicted growth tendency is attributed to changes in the legal framework, affordability trends, and technology advancements in the region's developing economies. Additionally, the existence of a diseased population boosts regional clinical trial-related activity, which raises the demand for NGS sample preparation.

Recent Developments:

  • In January 2024, Roche announced that Tecentriq SC (atezolizumab), the first subcutaneous (under the skin) injection of a PD-(L)1 cancer immunotherapy, to be approved for marketing by the European Commission. With Tecentriq, almost 38,000 European Union citizens were able to combat cancers of the lung, liver, bladder, and breast in the past year.
  • In January 2024, “Illumina Inc. has announced that it has signed an agreement with Janssen Research & Development, LLC (Janssen)”—Janssen being a world leader in DNA sequencing and array-based technologies. The groundbreaking molecular residual disease (MRD) assay, developed by Illumina, is a whole-genome sequencing (WGS) multi-cancer research solution that identifies circulating tumor DNA (ctDNA) to shed light on the disease's persistence or recurrence after therapeutic intervention. This partnership marks the first of its kind.

NGS Sample Preparation Market Report Scope

Report Attribute Specifications
Market Size Value In 2023 USD 4.10 Billion
Revenue Forecast In 2031 USD 9.51 Billion
Growth Rate CAGR CAGR of 11.35 % from 2024 to 2031
Quantitative Units Representation of revenue in US$ Billion and CAGR from 2024 to 2031
Historic Year 2019 to 2023
Forecast Year 2024-2031
Report Coverage The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends
Segments Covered By Products and Services, By Workflow, By Sample Type, By Method, By Application, By End-User
Regional Scope North America; Europe; Asia Pacific; Latin America; Middle East & Africa
Country Scope U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico ;The UK; France; Italy; Spain; China; Japan; India; South Korea; South East Asia; South Korea; South East Asia
Competitive Landscape Illumina, Inc. (US), Thermo Fisher Scientific Inc. (US), PerkinElmer Inc. (US), F. Hoffmann-La Roche Ltd. (Switzerland), Agilent Technologies, Inc. (US), Danaher (US), Becton, Dickinson and Company (US), Merck KGAA (Germany), QIAGEN (Germany),  Bio-Rad Laboratories, Inc. (US), Promega Corporation (US), Eurofins Scientific (Luxembourg), BGI (China), 10x Genomics (US), Sysmex Corporation (US), Psomagen (US), Zymo Research Corporation (US), Takara Bio Inc. (Japan), Novogene Co., Ltd. (China), New England Biolabs (US), Tecan Trading AG (US), Oxford Nanopore Technologies PLC (UK), PacBio (US), Medgenome (US), and Swift Biosciences Inc. (US).
Customization Scope Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape.
Pricing And Available Payment Methods Explore pricing alternatives that are customized to your particular study requirements.

Segmentation of NGS Sample Preparation Market

NGS Sample Preparation Market By Products & Services

  • Workstations/Instruments
  • Reagents & Consumables
  • Services

ngs sample preparation

NGS Sample Preparation Market By Workflow

  • DNA Fragmentation & Library Preparation
  • Target Enrichment
  • QC

NGS Sample Preparation Market By Sample Type

  • DNA
  • RNA

NGS Sample Preparation Market By Method

  • Manual Sample Preparation
  • Microfluidic Sample Preparation
  • Automated Liquid Handling-based Sample Preparation

NGS Sample Preparation Market By Application

  • Diagnostics
  • Drug Discovery
  • Agricultural & Animal Research
  • Others

NGS Sample Preparation Market By End User

  • Academic Institutes & Research Centers
  • Hospitals & Clinics
  • Pharma & Biotech Companies
  • Other End Users

NGS Sample Preparation Market By Region-

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

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Research Design and Approach

This study employed a multi-step, mixed-method research approach that integrates:

  • Secondary research
  • Primary research
  • Data triangulation
  • Hybrid top-down and bottom-up modelling
  • Forecasting and scenario analysis

This approach ensures a balanced and validated understanding of both macro- and micro-level market factors influencing the market.

Secondary Research

Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research.

Sources Consulted

Secondary data for the market study was gathered from multiple credible sources, including:

  • Government databases, regulatory bodies, and public institutions
  • International organizations (WHO, OECD, IMF, World Bank, etc.)
  • Commercial and paid databases
  • Industry associations, trade publications, and technical journals
  • Company annual reports, investor presentations, press releases, and SEC filings
  • Academic research papers, patents, and scientific literature
  • Previous market research publications and syndicated reports

These sources were used to compile historical data, market volumes/prices, industry trends, technological developments, and competitive insights.

Secondary Research

Primary Research

Primary research was conducted to validate secondary data, understand real-time market dynamics, capture price points and adoption trends, and verify the assumptions used in the market modelling.

Stakeholders Interviewed

Primary interviews for this study involved:

  • Manufacturers and suppliers in the market value chain
  • Distributors, channel partners, and integrators
  • End-users / customers (e.g., hospitals, labs, enterprises, consumers, etc., depending on the market)
  • Industry experts, technology specialists, consultants, and regulatory professionals
  • Senior executives (CEOs, CTOs, VPs, Directors) and product managers

Interview Process

Interviews were conducted via:

  • Structured and semi-structured questionnaires
  • Telephonic and video interactions
  • Email correspondences
  • Expert consultation sessions

Primary insights were incorporated into demand modelling, pricing analysis, technology evaluation, and market share estimation.

Data Processing, Normalization, and Validation

All collected data were processed and normalized to ensure consistency and comparability across regions and time frames.

The data validation process included:

  • Standardization of units (currency conversions, volume units, inflation adjustments)
  • Cross-verification of data points across multiple secondary sources
  • Normalization of inconsistent datasets
  • Identification and resolution of data gaps
  • Outlier detection and removal through algorithmic and manual checks
  • Plausibility and coherence checks across segments and geographies

This ensured that the dataset used for modelling was clean, robust, and reliable.

Market Size Estimation and Data Triangulation

Bottom-Up Approach

The bottom-up approach involved aggregating segment-level data, such as:

  • Company revenues
  • Product-level sales
  • Installed base/usage volumes
  • Adoption and penetration rates
  • Pricing analysis

This method was primarily used when detailed micro-level market data were available.

Bottom Up Approach

Top-Down Approach

The top-down approach used macro-level indicators:

  • Parent market benchmarks
  • Global/regional industry trends
  • Economic indicators (GDP, demographics, spending patterns)
  • Penetration and usage ratios

This approach was used for segments where granular data were limited or inconsistent.

Hybrid Triangulation Approach

To ensure accuracy, a triangulated hybrid model was used. This included:

  • Reconciling top-down and bottom-up estimates
  • Cross-checking revenues, volumes, and pricing assumptions
  • Incorporating expert insights to validate segment splits and adoption rates

This multi-angle validation yielded the final market size.

Forecasting Framework and Scenario Modelling

Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools.

Forecasting Methods

  • Time-series modelling
  • S-curve and diffusion models (for emerging technologies)
  • Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes)
  • Price elasticity models
  • Market maturity and lifecycle-based projections

Scenario Analysis

Given inherent uncertainties, three scenarios were constructed:

  • Base-Case Scenario: Expected trajectory under current conditions
  • Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds
  • Conservative Scenario: Slow adoption, regulatory delays, economic constraints

Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption.

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Frequently Asked Questions

The NGS Sample Preparation Market Size is valued at 4.10 Billion in 2023 and is predicted to reach 9.51 Billion by the year 2031.

The NGS Sample Preparation Market is expected to grow at a 11.35 % CAGR during the forecast period for 2024-2031.

Illumina, Inc. (US), Thermo Fisher Scientific Inc. (US), PerkinElmer Inc. (US), F. Hoffmann-La Roche Ltd. (Switzerland), Agilent Technologies, Inc. an
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