Global Viral Vector Purification Market

Report ID : 1287 | Published : 2022-07-04 | Pages: | Format: PDF/EXCEL

The Global Viral Vector Purification Market is estimated to reach over USD 18.37 billion by 2030, exhibiting a CAGR of 12.4% during the forecast period. 

Over 1,000 cell and gene therapy-related clinical trials are currently underway worldwide. Gene delivery vectors are critical in the development of cell and gene therapies since genetic manipulation is a prerequisite. So far, viral vectors (based on adeno-associated viruses (AAV), adenoviruses, lentiviruses, retroviruses, and other viruses) have been demonstrated to be the most versatile gene delivery tools available, with high transfection efficiencies in both preclinical and clinical settings. Besides that, given the therapeutic efficacy and low side effect profiles of cell and gene therapies, demand for such interventions is expected to rise rapidly, necessitating a proportional increase in demand for appropriate vector systems. Various techniques are currently used to purify viral vectors. Size-based viral purification strategies, such as density-gradient ultracentrifugation, ultrafiltration, precipitation, and size-exclusion chromatography (SEC), have become industry standards over the years.

Following the Covid-19 pandemic, many governments realized the importance of establishing research institutes in the fields of gene therapy and vaccine development. This trend of increasing investment in biotech and pharmaceutical companies is expected to boost the global market for viral vector products. Furthermore, the rising demand for synthetic genes and the untapped market potential are expected to show lucrative growth opportunities for market players in the future.

Market Segmentation:

The global viral vector purification market is segmented on the basis of product type, purification technique type, type of viral vector scope, and scale of operation. By product type, the market is segmented as a kit, prepacked column, resin, cassette, filter plate, capsule, and reagent. The other purification technique type segment includes chromatography, centrifugation, and filtration. The market is segmented by type of viral vector scope into AAV, adenovirus, lentivirus, retrovirus, and others. The other scale of operation segment includes lab-scale, clinical, and commercial. 

Based on the type of viral vector scope, the AAV segment is accounted as a significant contributor to the global viral vector purification market.

In 2020, AAV dominated the market with a significant market share. Due to their use in the majority of cell-based gene therapies, the adeno-associated viral vector manufacturing segment is anticipated to grow at the highest CAGR during the forecast period. Some of the significant facts that enable it to occupy a significant share of this vector in the overall market are its ability to integrate with large transgenes and simple production at high levels. Several companies and state organizations have successfully developed an AAV-based vaccine to prevent Covid-19 infection.

The clinical segment witnessed growth at a rapid rate.

In 2020, the clinical segment had the highest market share. The rising engagement of scientific communities in gene and cell therapy research is predicted to raise demand for viral vectors due to the high need for vectors for conducting research.

Furthermore, research organisations, pharmaceutical, and biopharmaceutical enterprises are developing as significant end-users of the market for viral vectors and plasmid DNA synthesis, adding to the launch of advanced medications and the number of gene therapy-based R&D activities. One of these companies, Abeona Therapeutics, is testing AAV9-based gene therapies for CLN1 and CLN3 disorders. As a result, it will fuel market growth.

In the region, the North American viral vector purification market holds a significant revenue share.

North America dominated the global viral vector purification market, accounting for nearly 50% of all revenue in 2020. This region has the highest demand for viral vector CDMO due to the concentration of research and development in the domain of advanced genetic therapies. The United States is the leading country in this region and the world in terms of revenue generation through ADVAC viral vector technology services. In addition, Investments made by federal agencies to expand the region's cell therapy research base are expected to boost the growth of the North American market. Besides, the Asia Pacific region is likely the fastest-growing region due to a growing patient population, increased R&D activities in this field, and other factors. Furthermore, patients from Western countries travel to Asian countries for stem cell therapy because the legal framework in this region is less restrictive.

Furthermore, the region's large population and untapped potential have resulted in a business shift for global firms in this region. Moreover, this region provides reasonably priced manufacturing and operating units for conducting research. These factors are expected to play a significant role in the expansion of the stem cell field in this region, boosting market growth even further.

Competitive Landscape

Some of the major key players in the global viral vector purification market are Agilent Technologies, BIA Separations, Bio-Rad Laboratories, BioVision, Cytiva (formerly GE Lifesciences), Merck, Sartorius, Takara Bio, and Thermo Fisher Scientific.

Chapter 1. Methodology and Scope

1.1. Research Methodology

1.2. Research Scope & Assumptions

Chapter 2. Executive Summary

Chapter 3. Global Viral Vector Purification / Virus Purification Products Market Snapshot

Chapter 4. Global Viral Vector Purification / Virus Purification Products Market Variables, Trends & Scope

4.1. Market Segmentation & Scope

4.2. Drivers

4.3. Challenges

4.4. Trends

4.5. Industry Analysis – Porter’s Five Forces Analysis

4.6. Competitive Landscape & Market Share Analysis

4.7. Major Investment, Partnerships and Collaborations in Gene Therapy Research

4.8. Covid-19 Impact on Healthcare Industry

Chapter 5. Market Segmentation 1: Product Type Estimates & Trend Analysis

5.1. Product Type & Market Share, 2020 & 2028

5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2028 for the following Product Type:

5.2.1. Kit

5.2.2. Prepacked Column

5.2.3. Resin

5.2.4. Cassette

5.2.5. Filter Plate

5.2.6. Capsule

5.2.7. Reagent

Chapter 6. Market Segmentation 2: Type of Purification Technique Estimates & Trend Analysis

6.1. Type of Purification Technique & Market Share, 2020 & 2028

6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2028 for the following Type of Purification Technique:

6.2.1. Chromatography

6.2.2. Centrifugation

6.2.3. Filtration

Chapter 7. Market Segmentation 3: Type of Viral Vector Estimates & Trend Analysis

7.1. Type of Viral Vector Type & Market Share, 2020& 2028

7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2028 for the following Type of Viral Vector Type:

7.2.1. AAV

7.2.2. Adenovirus

7.2.3. Lentivirus

7.2.4. Retrovirus

7.2.5. others

Chapter 8. Market Segmentation 4: Scale of Operation Estimates & Trend Analysis

8.1. Scale of Operation & Market Share, 2020 & 2028

8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2020 to 2028 for the following Scale of Operation:

8.2.1. Lab-scale

8.2.2. Clinical

8.2.3. Commercial

Chapter 9. Viral Vector Purification / Virus Purification Products Market Segmentation 3: Regional Estimates & Trend Analysis

9.1. North America

9.1.1. North America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) estimates and forecasts by Product Type, 2020-2028

9.1.2. North America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) estimates and forecasts by Type of Purification Technique, 2020-2028

9.1.3. North America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) estimates and forecasts by Type of Viral Vector, 2020-2028

9.1.4. North America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) estimates and forecasts by Scale of Operation, 2020-2028

9.1.5. North America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) estimates and forecasts by country, 2020-2028

9.2. Europe

9.2.1. Europe Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Product Type, 2020-2028

9.2.2. Europe Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Purification Technique, 2020-2028

9.2.3. Europe Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Viral Vector, 2020-2028

9.2.4. Europe Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Scale of Operation, 2020-2028

9.2.5. Europe Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by country, 2020-2028

9.3. Asia Pacific

9.3.1. Asia Pacific Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Product Type, 2020-2028

9.3.2. Asia Pacific Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Purification Technique, 2020-2028

9.3.3. Asia Pacific Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Viral Vector, 2020-2028

9.3.4. Asia Pacific Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Scale of Operation, 2020-2028

9.3.5. Asia Pacific Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by country, 2020-2028

9.4. Latin America

9.4.1. Latin America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Product Type, (US$ Million)

9.4.2. Latin America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Purification Technique, (US$ Million)

9.4.3. Latin America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Viral Vector, (US$ Million)

9.4.4. Latin America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Scale of Operation, 2020-2028

9.4.5. Latin America Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by country, (US$ Million) 2020-2028

9.5. Middle East & Africa

9.5.1. Middle East & Africa Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Product Type, (US$ Million)

9.5.2. Middle East & Africa Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Purification Technique, (US$ Million)

9.5.3. Middle East & Africa Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Type of Viral Vector, (US$ Million)

9.5.4. Middle East & Africa Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by Scale of Operation, 2020-2028

9.5.5. Middle East & Africa Viral Vector Purification / Virus Purification Products Market revenue (US$ Million) by country, (US$ Million) 2020-2028

Chapter 10. Competitive Landscape

10.1. Major Mergers and Acquisitions/Strategic Alliances

10.2. Company Profiles

10.2.1. Agilent Technologies

10.2.2. BIA Separations

10.2.3. Bio-Rad Laboratories

10.2.4. BioVision

10.2.5. Cytiva (formerly GE Lifesciences)

10.2.6. Merck

10.2.7. Sartorius

10.2.8. Takara Bio

10.2.9. Thermo Fisher Scientific

10.2.10. Other Prominent Player

Segmentation of Global Viral Vector Purification Market -

By Product Type -

  • Kit
  • Prepacked Column
  • Resin
  • Cassette
  • Filter Plate
  • Capsule
  • Reagent

By Purification Technique Type -

  • Chromatography
  • Centrifugation
  • Filtration

By Type of Viral Vector Scope -

  • AAV
  • Adenovirus
  • Lentivirus
  • Retrovirus
  • Others

By Scale of Operation -

  • Lab-scale
  • Clinical
  • Commercial

By Region -

North America -

  • The U.S.
  • Canada
  • Mexico

Europe -

  • Germany
  • The U.K.
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific -

  • China
  • Japan
  • India
  • South Korea
  • South East Asia
  • Rest of Asia Pacific

Latin America -

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa -

  • GCC Countries
  • South Africa

Rest of Middle East and Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

Need Complete Report ?

Frequently Asked Questions

Who are the Key Players in the Viral Vector Purification Market?

USD 18.37 billion by 2030

exhibiting a CAGR of 12.4% during the forecast period

Our Clients