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Protein Expression Market

Protein Expression Market, Share & Trends Analysis Report, By Type of Protein Expression System (Algal, Cell-free, Insect, Mammalian, Prokaryotic and Yeast), Protein Expression-related Offerings (Competent Cells, Expression Vectors, Instruments, Kits and Reagents, and Protein Expression Services), Application Aera, End-Users, Type of Operation, By Region, and Segment Forecasts, 2024-2031

Report ID : 2823 | Published : 2024-10-04 | Pages: 165 | Format: PDF/EXCEL/Power BI Dashbord

The Protein Expression Market Size is valued at USD 2.5 Bn in 2023 and is predicted to reach USD 4.6 Bn by the year 2031 at an 7.7% CAGR during the forecast period for 2024-2031.

protein expression market

The technique of creating an artificial protein, known as a heterologous protein, involves introducing recombinant DNA into a host cell, a process that exemplifies the essential biological function of protein expression. This fundamental process is so critical that even the simplest prokaryotic organisms dedicate nearly 80% of their energy and over half of their dry weight to it. Cells, as the basic building blocks of life, must synthesize proteins using the instructions encoded in their DNA, as these proteins determine their unique shapes and structures. According to the fundamental dogma of molecular biology, genetic information flows from DNA to RNA through transcription and is then translated into proteins, highlighting the intricate connection between genetics and cellular function.

In June 2024, the Broad Institute unveiled a groundbreaking epigenetic editing method capable of permanently silencing the gene responsible for producing prion proteins in the brain using molecular tools. This innovative approach, which involves a single intravenous injection of a modified adeno-associated virus (AAV), has shown promising results in animal studies, reducing prion protein levels by over 80%, and potentially paving the way for new treatments for prion diseases. In a related development, the FDA approved fifty new medications in 2021, including fourteen biologics—such as monoclonal antibodies, pegylated proteins, hormones, and enzymes—all of which require protein expression. Notably, the approval of upheld, a co-packaged preventive treatment, and various monoclonal antibodies like tocilizumab and sotrovimab for COVID-19 further highlighted the importance of protein biologics. As the FDA was expected to approve several additional medications in 2022, the growing demand for these products has significantly increased the need for protein expression goods and services, driving market expansion.

Competitive Landscape

Some of the Major Key Players in the Protein Expression Market are

  • Agilent Technologies
  • Ajinomoto Bio-Pharma Services
  • Aldevron
  • Artes Biotechnology Gmbh
  • Bio-Rad Laboratories
  • Bioneer Corporation
  • Cayman Chemical
  • Charles River Laboratories
  • Corning Incorporated
  • Domainex
  • Danaher Corporation
  • Eurofins Calixar
  • Fujifilm Irvine Scientific, Inc.
  • Genext Genomics
  • Genscript Biotech
  • Lonza
  • Lucigen Corporation
  • Lifesensors Inc
  • Leading Biology, Inc.
  • Merck Kgaa
  • New England Biolabs
  • Oxford Expression Technologies
  • Promab
  • Promega
  • Proteogenix
  • Peak Proteins Ltd
  • Qiagen
  • Sartorius
  • Synbio Technologies
  • Syngene
  • Synthetic Genomics Inc
  • Sino Biological Inc
  • Jena Bioscience
  • Takara Bio
  • Thermo Fisher Scientific
  • Wuxi Biologics

Market Segmentation

The Protein Expression Market is segmented based on the type of protein expression system, protein expression-related offerings, application area, end-users, and type of operation. Based on the type of protein expression system, the market is divided into algal, cell-free, insect, mammalian, prokaryotic, and yeast. Based on the Protein Expression-related Offerings, the market is divided into competent cells, expression vectors, instruments, kits and reagents, and protein expression services.  The market is categorized into academic and research institutes, CROS and CDMOS, pharmaceutical/biotechnology companies, and other end-users based on the end user. Based on the application area, the market is categorized into research and diagnostics, and therapeutics. Based on the type of operation, the market is categorized into In-house and outsourced operations.

The Prokaryotic Expression Systems Segment is Expected to Have the Highest Growth Rate During the Forecast Period

Based on the type of protein expression system, the market is divided into algal, cell-free, insect, mammalian, prokaryotic, and yeast. Among these, prokaryotic expression systems (particularly Escherichia coli) typically drive and hold the largest share of the protein expression market. his is due to their simplicity, cost-effectiveness, high yield, and rapid production rates. Prokaryotic systems are widely used in research and industrial applications to produce recombinant proteins. However, as the demand for more complex proteins grows, other systems like mammalian and yeast expression systems are also gaining significance for their ability to produce proteins with proper post-translational modifications. The ease of scaling up production in prokaryotic systems enables industrial-level protein manufacturing, making them ideal for large-scale applications like enzyme production, research, and biopharmaceuticals.

The Kits and Reagents Segment Dominates the Market

Based on the protein expression-related offerings, the market is divided into competent cells, expression vectors, instruments, kits and reagents, and protein expression services. Among these, kits and reagents dominate the protein expression market. This is because bio-experiments typically require a large volume of reagents for various steps in the protein production process. Reagents are crucial for every stage of protein expression, including cell preparation, vector transformation, and protein isolation. The high demand for these essential components, combined with their repeated use in experiments, makes them the largest revenue-generating segment in the protein expression market. Additionally, the growing need for reagents in both research and industrial applications further drives their dominance in the market.

North America Has the Largest Market Share During the Forecast Period.

North America, particularly the United States, is home to a highly developed biotechnology and pharmaceutical sector. Leading companies and research institutions in these fields are driving demand for protein expression technologies for drug development, biologics, and biosimilars. The region benefits from substantial investment in R&D from both government bodies and private organizations. This funding supports innovations in protein expression systems, enhancing productivity and fostering new therapeutic applications. The rising incidence of chronic diseases, such as cancer, diabetes, and autoimmune disorders, in North America creates a high demand for protein-based therapeutics like monoclonal antibodies and vaccines, fueling the protein expression market.

Recent Developments:

  • In June 2024, Syngene International Ltd., A protein production platform was introduced by a global contract research, development, and manufacturing organization (CRDMO) to facilitate rapid production. The platform makes use of transposon- and cell line-based technology licensed from ExcellGene, a biotech services business with headquarters in Switzerland.
  • In July 2024, Agilent Technologies Inc., announced at the Singapore Cell and Gene Therapy Pan Asia Summit (SCGT) the debut of its new ProteoAnalyzer system in addition to improvements to its current line of products. The automated parallel capillary electrophoresis (CE) solution from Agilent is a revolutionary protein analysis platform that combines quick, high-resolution analysis with less sample consumption. This facilitates the analysis of intricate protein blends by researchers, leading to expedited discoveries in the fields of pharma, biopharma, and bioengineered food ingredients.

Protein Expression Market Report Scope

Report Attribute

Specifications

Market Size Value In 2023

USD 2.5 Bn

Revenue Forecast In 2031

USD 4.6 Bn

Growth Rate CAGR

CAGR of 7.7% from 2024 to 2031

Quantitative Units

Representation of revenue in US$ Bn and CAGR from 2024 to 2031

Historic Year

2019 to 2023

Forecast Year

2024-2031

Report Coverage

The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends

Segments Covered

By Type Of Protein Expression System, Protein Expression-Related Offerings, Application Area, End-Users, And Type of Operation

Regional Scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country Scope

U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South Korea; South East Asia

Competitive Landscape

Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomics, GenScript Biotech, Lonza , Merck KGaA, New England Biolabs, ProMab, Promega , ProteoGenix, QIAGEN, and other prominent players

Customization Scope

Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape.

Pricing and Available Payment Methods

Explore pricing alternatives that are customized to your particular study requirements.

Chapter 1.          Methodology and Scope

1.1.        Research Methodology

1.2.        Research Scope & Assumptions

Chapter 2.          Executive Summary

Chapter 3.          Global Protein Expression Market Snapshot

Chapter 4.          Global Protein Expression Market Variables, Trends & Scope

4.1.        Market Segmentation & Scope

4.2.        Drivers

4.3.        Challenges

4.4.        Trends

4.5.        Investment and Funding Analysis

4.6.        Porter's Five Forces Analysis

4.7.        Incremental Opportunity Analysis (US$ MN), 2024-2031

4.8.        Global Protein Expression Market Penetration & Growth Prospect Mapping (US$ Mn), 2023-2031

4.9.        Competitive Landscape & Market Share Analysis, By Key Player (2023)

4.10.     Use/impact of AI on Protein Expression Industry Trends

Chapter 5.          Protein Expression Market Segmentation 1: By Type of Protein Expression System, Estimates & Trend Analysis

5.1.        Market Share by Type of Protein Expression System, 2023 & 2031

5.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Protein Expression System:

5.2.1.    Algal Expression Systems

5.2.2.    Cell-free Expression Systems

5.2.3.    Insect Expression Systems

5.2.4.    Mammalian Expression Systems

5.2.5.    Prokaryotic Expression Systems

5.2.6.    Yeast Expression Systems

Chapter 6.          Protein Expression Market Segmentation 2: By Protein Expression-related Offerings, Estimates & Trend Analysis

6.1.        Market Share by Application, 2023 & 2031

6.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Protein Expression-related Offerings:

6.2.1.    Competent Cells

6.2.2.    Expression Vectors

6.2.3.    Instruments

6.2.4.    Kits and Reagents

6.2.5.    Protein Expression Services

Chapter 7.          Protein Expression Market Segmentation 3: By Type of Operation, Estimates & Trend Analysis

7.1.        Market Share by Type of Operation, 2023 & 2031

7.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Operations:

7.2.1.    In-house Operations

7.2.2.    Outsourced Operations

Chapter 8.          Protein Expression Market Segmentation 4: By End Users, Estimates & Trend Analysis

8.1.        Market Share by End Users, 2023 & 2031

8.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following End Userss:

8.2.1.    Academic and Research Institutes

8.2.2.    CROs and CDMOs

8.2.3.    Pharmaceutical and Biotechnology Companies

8.2.4.    Other End-users

8.2.5.    Type of Operation          

8.2.6.    In-house Operations

8.2.7.    Outsourced Operations

Chapter 9.          Protein Expression Market Segmentation 5: By Application Area, Estimates & Trend Analysis

9.1.        Market Share by Application Area, 2023 & 2031

9.2.        Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Application Areas:

9.2.1.    Research and Diagnostics

9.2.2.    Therapeutics

Chapter 10.        Protein Expression Market Segmentation 6: Regional Estimates & Trend Analysis

10.1.     Global Protein Expression Market, Regional Snapshot 2023 & 2031

10.2.     North America

10.2.1.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031

10.2.1.1.             US

10.2.1.2.             Canada

10.2.2.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031

10.2.3.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031

10.2.4.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031

10.2.5.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031

10.2.6.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031

10.2.7.  North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031

10.3.     Europe

10.3.1.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2019-2031

10.3.1.1.             Germany

10.3.1.2.             U.K.

10.3.1.3.             France

10.3.1.4.             Italy

10.3.1.5.             Spain

10.3.1.6.             Rest of Europe

10.3.2.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031

10.3.3.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2019-2031

10.3.4.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031

10.3.5.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031

10.3.6.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031

10.3.7.  Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031

10.4.     Asia Pacific

10.4.1.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031

10.4.1.1.             India

10.4.1.2.             China

10.4.1.3.             Japan

10.4.1.4.             Australia

10.4.1.5.             South Korea

10.4.1.6.             Hong Kong

10.4.1.7.             Southeast Asia

10.4.1.8.             Rest of Asia Pacific

10.4.2.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031

10.4.3.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031

10.4.4.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031

10.4.5.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts By Type of Operation, 2024-2031

10.4.6.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031

10.4.7.  Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts By Application Area, 2024-2031

10.5.     Latin America

10.5.1.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031

10.5.1.1.             Brazil

10.5.1.2.             Mexico

10.5.1.3.             Rest of Latin America

10.5.2.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031

10.5.3.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031

10.5.4.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application2024-2031

10.5.5.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031

10.5.6.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by radioisotope, 2024-2031

10.5.7.  Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031

10.6.     Middle East & Africa

10.6.1.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031

10.6.1.1.             GCC Countries

10.6.1.2.             Israel

10.6.1.3.             South Africa

10.6.1.4.             Rest of Middle East and Africa

10.6.2.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031

10.6.3.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031

10.6.4.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by application, 2024-2031

10.6.5.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031

10.6.6.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by radioisotope, 2024-2031

10.6.7.  Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031

Chapter 11.        Competitive Landscape

11.1.     Major Mergers and Acquisitions/Strategic Alliances

11.2.     Company Profiles

 

11.2.1.  Agilent Technologies

11.2.1.1.             Business Overview

11.2.1.2.             Key Product/Service Offerings

11.2.1.3.             Financial Performance

11.2.1.4.             Geographical Presence

11.2.1.5.             Recent Developments with Business Strategy

11.2.2.  Ajinomoto Bio-Pharma Services

11.2.3.  Aldevron

11.2.4.  ARTES Biotechnology GmbH

11.2.5.  Bio-Rad Laboratories

11.2.6.  BIONEER CORPORATION

11.2.7.  Cayman Chemical

11.2.8.  Charles River Laboratories

11.2.9.  CORNING INCORPORATED

11.2.10.              Domainex

11.2.11.              DANAHER CORPORATION

11.2.12.              Eurofins CALIXAR

11.2.13.              FUJIFILM IRVINE SCIENTIFIC, INC.

11.2.14.              GeNext Genomics

11.2.15.              GenScript Biotech

11.2.16.              Lonza

11.2.17.              Lucigen Corporation

11.2.18.              LifeSensors Inc

11.2.19.              LEADING BIOLOGY, INC.

11.2.20.              Merck KGaA

11.2.21.              New England Biolabs

11.2.22.              Oxford Expression Technologies

11.2.23.              ProMab

11.2.24.              Promega

11.2.25.              ProteoGenix

11.2.26.              Peak Proteins Ltd

11.2.27.              QIAGEN

11.2.28.              Sartorius

11.2.29.              Synbio Technologies

11.2.30.              Syngene

11.2.31.              Synthetic Genomics Inc

11.2.32.              Sino Biological Inc

11.2.33.              JENA BIOSCIENCE

11.2.34.              Takara Bio

11.2.35.              Thermo Fisher Scientific

11.2.36.              WuXi Biologics

11.2.37.              Other Prominent Players

 

Segmentation of Protein Expression Market

Global Protein Expression Market- By Type of Protein Expression System

  • Algal Expression Systems
  • Cell-free Expression Systems
  • Insect Expression Systems
  • Mammalian Expression Systems
  • Prokaryotic Expression Systems
  • Yeast Expression Systems

protein expression market

Global Protein Expression Market – Protein Expression-related Offerings  

  • Competent Cells
  • Expression Vectors
  • Instruments
  • Kits and Reagents
  • Protein Expression Services

Global Protein Expression Market – By Application

  • Research and Diagnostics
  • Therapeutics

Global Protein Expression Market – By End user

  • Academic and Research Institutes
  • CROs and CDMOs
  • Pharmaceutical and Biotechnology Companies
  • Other End-users
  • Type of Operation
  • In-house Operations
  • Outsourced Operations

Global Protein Expression Market – Type of Operation     

  • In-house Operations
  • Outsourced Operations

Global Protein Expression Market – By Region

North America-

  • The US
  • Canada
  • Mexico

Europe-

  • Germany
  • The UK
  • France
  • Italy
  • Spain
  • Rest of Europe

Asia-Pacific-

  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific

Latin America-

  • Brazil
  • Argentina
  • Rest of Latin America

 Middle East & Africa-

  • GCC Countries
  • South Africa
  • Rest of the Middle East and Africa

 

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

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Frequently Asked Questions

How big is the Protein Expression Market Size?

The Protein Expression Market is expected to grow at an 7.7% CAGR during the forecast period for 2024-2031.

Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomic

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