Global Cancer Angiogenesis Pipeline Market

Report ID : 1066 | Published : 2022-08-16 | Pages: 140 | Format: PDF/EXCEL

The preceding decades have shown higher incidence and prevalence trends for cancer. Globally, the scenario is worsening with the mounting number of cancer patients every year. The number of new cancer cases is predicted to rise by 54% within the next two decades. In economically developing countries, adoption of western lifestyles, such as smoking, poor diet, physical inactivity, and fewer childbirths, will gradually increase the burden of the treatment. This requirement has made cancer the most competitive and most studied arena.
Varied classes of chemotherapeutic products are available, ranging from monoclonal antibodies, vaccines, immunomodulators, and hormonal therapies to bispecific monoclonal antibodies. Raising the limitations of these therapies are that either they should be given in conjunction with other treatments, require a high dose or have got side effects and so on. Pharmacological parameters, overlapping boundaries, cost-effectiveness also are the significant limitations in these products.
One of the major segments of cancer therapy is occupied by angiogenesis inhibitors. Angiogenesis inhibitors are unique cancer-fighting agents because they block the growth of blood vessels that support tumor growth rather than blocking the growth of tumor cells themselves. Being a new targeted therapy, angiogenesis inhibitors have gained more focus and interest and have optimistic market opportunities. With the advent of new and improved technology, angiogenesis inhibitors therapy witnessed a drastic transition and is becoming more acceptable due to its site specific approach. Several regulatory and signaling molecules governing angiogenesis are of interest, including growth factors (e.g., VEGF, PDGF, FGF, EGF), receptor tyrosine kinases, transcription factors such as HIF, as well as molecules involved in MAPK and PI3K signaling.
In some cancers, angiogenesis inhibitors appear to be most effective when combined with additional therapies. There are now several agents available in the market such as bevacizumab (Avastin™) that target the tumor vasculature through different pathways, either by inhibiting the formation of the tumor neovasculature or by directly targeting the mature tumor vessels. Because angiogenesis inhibitors work by slowing or stopping tumor growth without killing cancer cells, they are given over a long period.
Therapeutic innovations in various segments have made human acceptance of the new targeted therapies. Now, many of angiogenesis inhibitors are being tested as adjuvant or first-line therapies to determine their efficacy in improving survival. Although majorly angiogenesis inhibitors are used as supportive therapy rather than streamline drugs as they take huge time to even show reasonable results.
An extensive array of compounds is currently in pre-clinical development(Sonepcizumab/Pfizer, KER-1003/Keros, Beperminogene perplasmid/Anges), with many now in the clinic (RG7594/Roche-Phase 1, Darleukin/Philogen-Phase 2, Ofranergene obadenovec/ VBL Therapeutics-Phase 3) and/or achieving FDA approval.
Some of the key players include Acceleron Pharma, Advenchen Laboratories, Allergan, Alnylam Pharmaceuticals, Amgen, Biocon, Celgene, Five Prime Therapeutics, Fujifilm Kyowa Kirin Biologics, Roche, Novartis, Neumedicines, Onyx, Pfizer, TaiRx, TBG Diagnostics, XBiotech.
Hence, it is quite predictable that the global market for angiogenesis inhibitors for cancer treatment is expected to register a healthy annual market growth rate. The healthy growth rate can be related to the cumulative effects such as fast technological development, upsurge in the number of incidences of cancer patients, rise in the increasing adverse effects from chemotherapy, and increase in the prevalence of cancer patients around the globe.

  • Acceleron Pharma
  • Advenchen Laboratories
  • Allergan
  • Alnylam Pharmaceuticals
  • Amgen
  • Biocon
  • Celgene
  • Five Prime Therapeutics
  • Fujifilm Kyowa Kirin Biologics
  • Roche
  • Novartis
  • Neumedicines
  • Onyx
  • Pfizer
  • TaiRx
  • TBG Diagnostics
  • XBiotech
  • Other Prominent Player with Pipeline Product Portfolio

Global Cancer Angiogenesis Pipeline Market Outlook (Revenue, US$ Mn, 2019 – 2030)

  • Market overview
  • Epidemiological data and Forecast
  • Economic impact on Cancer Angiogenesis Inhibitors
  • Pipeline Analysis: Current and Future Market opportunity
  • Key Market Trends
  • Key Mergers and Acquisitions
  • Cancer angiogenesis inhibitor Manufacturing Cost Analysis
  • Competition Landscape
  • Key News/Industry Activities

Global Cancer Angiogenesis Market Outlook (Revenue, US$ Mn, 2019 – 2030) By Region

  • Europe
    • U.K.
    • Germany
    • France
    • Italy
    • Spain
    • Russia
    • Rest of Europe
  • North America
    • U.S.
    • Canada
  • Asia Pacific
    • India
    • China
    • Japan
    • South Korea
    • Australia & New Zealand
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.

Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.

Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.

Secondary research

The secondary research sources that are typically mentioned to include, but are not limited to:

  • Company websites, financial reports, annual reports, investor presentations, broker reports, and SEC filings.
  • External and internal proprietary databases, regulatory databases, and relevant patent analysis
  • Statistical databases, National government documents, and market reports
  • Press releases, news articles, and webcasts specific to the companies operating in the market

The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista

Primary Research:

Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies

The contributors who typically take part in such a course include, but are not limited to: 

  • Industry participants: CEOs, CBO, CMO, VPs, marketing/ type managers, corporate strategy managers, and national sales managers, technical personnel, purchasing managers, resellers, and distributors.
  • Outside experts: Valuation experts, Investment bankers, research analysts specializing in specific markets
  • Key opinion leaders (KOLs) specializing in unique areas corresponding to various industry verticals
  • End-users: Vary mainly depending upon the market

Data Modeling and Analysis:

In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.

The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.

To know more about the research methodology used for this study, kindly contact us/click here.

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