The Protein Expression Market Size is valued at USD 2.5 Bn in 2023 and is predicted to reach USD 4.6 Bn by the year 2031 at an 7.7% CAGR during the forecast period for 2024-2031.
The technique of creating an artificial protein, known as a heterologous protein, involves introducing recombinant DNA into a host cell, a process that exemplifies the essential biological function of protein expression. This fundamental process is so critical that even the simplest prokaryotic organisms dedicate nearly 80% of their energy and over half of their dry weight to it. Cells, as the basic building blocks of life, must synthesize proteins using the instructions encoded in their DNA, as these proteins determine their unique shapes and structures. According to the fundamental dogma of molecular biology, genetic information flows from DNA to RNA through transcription and is then translated into proteins, highlighting the intricate connection between genetics and cellular function.
In June 2024, the Broad Institute unveiled a groundbreaking epigenetic editing method capable of permanently silencing the gene responsible for producing prion proteins in the brain using molecular tools. This innovative approach, which involves a single intravenous injection of a modified adeno-associated virus (AAV), has shown promising results in animal studies, reducing prion protein levels by over 80%, and potentially paving the way for new treatments for prion diseases. In a related development, the FDA approved fifty new medications in 2021, including fourteen biologics—such as monoclonal antibodies, pegylated proteins, hormones, and enzymes—all of which require protein expression. Notably, the approval of upheld, a co-packaged preventive treatment, and various monoclonal antibodies like tocilizumab and sotrovimab for COVID-19 further highlighted the importance of protein biologics. As the FDA was expected to approve several additional medications in 2022, the growing demand for these products has significantly increased the need for protein expression goods and services, driving market expansion.
The Protein Expression Market is segmented based on the type of protein expression system, protein expression-related offerings, application area, end-users, and type of operation. Based on the type of protein expression system, the market is divided into algal, cell-free, insect, mammalian, prokaryotic, and yeast. Based on the Protein Expression-related Offerings, the market is divided into competent cells, expression vectors, instruments, kits and reagents, and protein expression services. The market is categorized into academic and research institutes, CROS and CDMOS, pharmaceutical/biotechnology companies, and other end-users based on the end user. Based on the application area, the market is categorized into research and diagnostics, and therapeutics. Based on the type of operation, the market is categorized into In-house and outsourced operations.
Based on the type of protein expression system, the market is divided into algal, cell-free, insect, mammalian, prokaryotic, and yeast. Among these, prokaryotic expression systems (particularly Escherichia coli) typically drive and hold the largest share of the protein expression market. his is due to their simplicity, cost-effectiveness, high yield, and rapid production rates. Prokaryotic systems are widely used in research and industrial applications to produce recombinant proteins. However, as the demand for more complex proteins grows, other systems like mammalian and yeast expression systems are also gaining significance for their ability to produce proteins with proper post-translational modifications. The ease of scaling up production in prokaryotic systems enables industrial-level protein manufacturing, making them ideal for large-scale applications like enzyme production, research, and biopharmaceuticals.
Based on the protein expression-related offerings, the market is divided into competent cells, expression vectors, instruments, kits and reagents, and protein expression services. Among these, kits and reagents dominate the protein expression market. This is because bio-experiments typically require a large volume of reagents for various steps in the protein production process. Reagents are crucial for every stage of protein expression, including cell preparation, vector transformation, and protein isolation. The high demand for these essential components, combined with their repeated use in experiments, makes them the largest revenue-generating segment in the protein expression market. Additionally, the growing need for reagents in both research and industrial applications further drives their dominance in the market.
North America, particularly the United States, is home to a highly developed biotechnology and pharmaceutical sector. Leading companies and research institutions in these fields are driving demand for protein expression technologies for drug development, biologics, and biosimilars. The region benefits from substantial investment in R&D from both government bodies and private organizations. This funding supports innovations in protein expression systems, enhancing productivity and fostering new therapeutic applications. The rising incidence of chronic diseases, such as cancer, diabetes, and autoimmune disorders, in North America creates a high demand for protein-based therapeutics like monoclonal antibodies and vaccines, fueling the protein expression market.
Report Attribute |
Specifications |
Market Size Value In 2023 |
USD 2.5 Bn |
Revenue Forecast In 2031 |
USD 4.6 Bn |
Growth Rate CAGR |
CAGR of 7.7% from 2024 to 2031 |
Quantitative Units |
Representation of revenue in US$ Bn and CAGR from 2024 to 2031 |
Historic Year |
2019 to 2023 |
Forecast Year |
2024-2031 |
Report Coverage |
The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
Segments Covered |
By Type Of Protein Expression System, Protein Expression-Related Offerings, Application Area, End-Users, And Type of Operation |
Regional Scope |
North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
Country Scope |
U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; France; Italy; Spain; South Korea; South East Asia |
Competitive Landscape |
Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomics, GenScript Biotech, Lonza , Merck KGaA, New England Biolabs, ProMab, Promega , ProteoGenix, QIAGEN, and other prominent players |
Customization Scope |
Free customization report with the procurement of the report and modifications to the regional and segment scope. Particular Geographic competitive landscape. |
Pricing and Available Payment Methods |
Explore pricing alternatives that are customized to your particular study requirements. |
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Protein Expression Market Snapshot
Chapter 4. Global Protein Expression Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2024-2031
4.8. Global Protein Expression Market Penetration & Growth Prospect Mapping (US$ Mn), 2023-2031
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2023)
4.10. Use/impact of AI on Protein Expression Industry Trends
Chapter 5. Protein Expression Market Segmentation 1: By Type of Protein Expression System, Estimates & Trend Analysis
5.1. Market Share by Type of Protein Expression System, 2023 & 2031
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Protein Expression System:
5.2.1. Algal Expression Systems
5.2.2. Cell-free Expression Systems
5.2.3. Insect Expression Systems
5.2.4. Mammalian Expression Systems
5.2.5. Prokaryotic Expression Systems
5.2.6. Yeast Expression Systems
Chapter 6. Protein Expression Market Segmentation 2: By Protein Expression-related Offerings, Estimates & Trend Analysis
6.1. Market Share by Application, 2023 & 2031
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Protein Expression-related Offerings:
6.2.1. Competent Cells
6.2.2. Expression Vectors
6.2.3. Instruments
6.2.4. Kits and Reagents
6.2.5. Protein Expression Services
Chapter 7. Protein Expression Market Segmentation 3: By Type of Operation, Estimates & Trend Analysis
7.1. Market Share by Type of Operation, 2023 & 2031
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Type of Operations:
7.2.1. In-house Operations
7.2.2. Outsourced Operations
Chapter 8. Protein Expression Market Segmentation 4: By End Users, Estimates & Trend Analysis
8.1. Market Share by End Users, 2023 & 2031
8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following End Userss:
8.2.1. Academic and Research Institutes
8.2.2. CROs and CDMOs
8.2.3. Pharmaceutical and Biotechnology Companies
8.2.4. Other End-users
8.2.5. Type of Operation
8.2.6. In-house Operations
8.2.7. Outsourced Operations
Chapter 9. Protein Expression Market Segmentation 5: By Application Area, Estimates & Trend Analysis
9.1. Market Share by Application Area, 2023 & 2031
9.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2019 to 2031 for the following Application Areas:
9.2.1. Research and Diagnostics
9.2.2. Therapeutics
Chapter 10. Protein Expression Market Segmentation 6: Regional Estimates & Trend Analysis
10.1. Global Protein Expression Market, Regional Snapshot 2023 & 2031
10.2. North America
10.2.1. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031
10.2.1.1. US
10.2.1.2. Canada
10.2.2. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031
10.2.3. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031
10.2.4. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
10.2.5. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031
10.2.6. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031
10.2.7. North America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031
10.3. Europe
10.3.1. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2019-2031
10.3.1.1. Germany
10.3.1.2. U.K.
10.3.1.3. France
10.3.1.4. Italy
10.3.1.5. Spain
10.3.1.6. Rest of Europe
10.3.2. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031
10.3.3. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2019-2031
10.3.4. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
10.3.5. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031
10.3.6. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031
10.3.7. Europe Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031
10.4. Asia Pacific
10.4.1. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031
10.4.1.1. India
10.4.1.2. China
10.4.1.3. Japan
10.4.1.4. Australia
10.4.1.5. South Korea
10.4.1.6. Hong Kong
10.4.1.7. Southeast Asia
10.4.1.8. Rest of Asia Pacific
10.4.2. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031
10.4.3. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031
10.4.4. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application, 2024-2031
10.4.5. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts By Type of Operation, 2024-2031
10.4.6. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by End Users, 2024-2031
10.4.7. Asia Pacific Protein Expression Market Revenue (US$ Million) Estimates and Forecasts By Application Area, 2024-2031
10.5. Latin America
10.5.1. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Country, 2024-2031
10.5.1.1. Brazil
10.5.1.2. Mexico
10.5.1.3. Rest of Latin America
10.5.2. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031
10.5.3. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031
10.5.4. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application2024-2031
10.5.5. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031
10.5.6. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by radioisotope, 2024-2031
10.5.7. Latin America Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031
10.6. Middle East & Africa
10.6.1. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by country, 2024-2031
10.6.1.1. GCC Countries
10.6.1.2. Israel
10.6.1.3. South Africa
10.6.1.4. Rest of Middle East and Africa
10.6.2. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Protein Expression System, 2024-2031
10.6.3. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Protein Expression-related Offerings, 2024-2031
10.6.4. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by application, 2024-2031
10.6.5. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Type of Operation, 2024-2031
10.6.6. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by radioisotope, 2024-2031
10.6.7. Middle East & Africa Protein Expression Market Revenue (US$ Million) Estimates and Forecasts by Application Area, 2024-2031
Chapter 11. Competitive Landscape
11.1. Major Mergers and Acquisitions/Strategic Alliances
11.2. Company Profiles
11.2.1. Agilent Technologies
11.2.1.1. Business Overview
11.2.1.2. Key Product/Service Offerings
11.2.1.3. Financial Performance
11.2.1.4. Geographical Presence
11.2.1.5. Recent Developments with Business Strategy
11.2.2. Ajinomoto Bio-Pharma Services
11.2.3. Aldevron
11.2.4. ARTES Biotechnology GmbH
11.2.5. Bio-Rad Laboratories
11.2.6. BIONEER CORPORATION
11.2.7. Cayman Chemical
11.2.8. Charles River Laboratories
11.2.9. CORNING INCORPORATED
11.2.10. Domainex
11.2.11. DANAHER CORPORATION
11.2.12. Eurofins CALIXAR
11.2.13. FUJIFILM IRVINE SCIENTIFIC, INC.
11.2.14. GeNext Genomics
11.2.15. GenScript Biotech
11.2.16. Lonza
11.2.17. Lucigen Corporation
11.2.18. LifeSensors Inc
11.2.19. LEADING BIOLOGY, INC.
11.2.20. Merck KGaA
11.2.21. New England Biolabs
11.2.22. Oxford Expression Technologies
11.2.23. ProMab
11.2.24. Promega
11.2.25. ProteoGenix
11.2.26. Peak Proteins Ltd
11.2.27. QIAGEN
11.2.28. Sartorius
11.2.29. Synbio Technologies
11.2.30. Syngene
11.2.31. Synthetic Genomics Inc
11.2.32. Sino Biological Inc
11.2.33. JENA BIOSCIENCE
11.2.34. Takara Bio
11.2.35. Thermo Fisher Scientific
11.2.36. WuXi Biologics
11.2.37. Other Prominent Players
Global Protein Expression Market- By Type of Protein Expression System
Global Protein Expression Market – Protein Expression-related Offerings
Global Protein Expression Market – By Application
Global Protein Expression Market – By End user
Global Protein Expression Market – Type of Operation
Global Protein Expression Market – By Region
North America-
Europe-
Asia-Pacific-
Latin America-
Middle East & Africa-
InsightAce Analytic follows a standard and comprehensive market research methodology focused on offering the most accurate and precise market insights. The methods followed for all our market research studies include three significant steps – primary research, secondary research, and data modeling and analysis - to derive the current market size and forecast it over the forecast period. In this study, these three steps were used iteratively to generate valid data points (minimum deviation), which were cross-validated through multiple approaches mentioned below in the data modeling section.
Through secondary research methods, information on the market under study, its peer, and the parent market was collected. This information was then entered into data models. The resulted data points and insights were then validated by primary participants.
Based on additional insights from these primary participants, more directional efforts were put into doing secondary research and optimize data models. This process was repeated till all data models used in the study produced similar results (with minimum deviation). This way, this iterative process was able to generate the most accurate market numbers and qualitative insights.
Secondary research
The secondary research sources that are typically mentioned to include, but are not limited to:
The paid sources for secondary research like Factiva, OneSource, Hoovers, and Statista
Primary Research:
Primary research involves telephonic interviews, e-mail interactions, as well as face-to-face interviews for each market, category, segment, and subsegment across geographies
The contributors who typically take part in such a course include, but are not limited to:
Data Modeling and Analysis:
In the iterative process (mentioned above), data models received inputs from primary as well as secondary sources. But analysts working on these models were the key. They used their extensive knowledge and experience about industry and topic to make changes and fine-tuning these models as per the product/service under study.
The standard data models used while studying this market were the top-down and bottom-up approaches and the company shares analysis model. However, other methods were also used along with these – which were specific to the industry and product/service under study.